ES2290885T3 - Derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina y compuestos afines como ligandos para el receptor gaba para el tratamiento de la ansiedad, depresion y epilepsia. - Google Patents
Derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina y compuestos afines como ligandos para el receptor gaba para el tratamiento de la ansiedad, depresion y epilepsia. Download PDFInfo
- Publication number
- ES2290885T3 ES2290885T3 ES05707562T ES05707562T ES2290885T3 ES 2290885 T3 ES2290885 T3 ES 2290885T3 ES 05707562 T ES05707562 T ES 05707562T ES 05707562 T ES05707562 T ES 05707562T ES 2290885 T3 ES2290885 T3 ES 2290885T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- methyl
- alkyl
- compound
- hexylsulfanyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100830 | 2004-03-02 | ||
| EP04100830 | 2004-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2290885T3 true ES2290885T3 (es) | 2008-02-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05707562T Expired - Lifetime ES2290885T3 (es) | 2004-03-02 | 2005-02-22 | Derivados de 4-(sulfanil-pirimidin-4-ilmetil)-morfolina y compuestos afines como ligandos para el receptor gaba para el tratamiento de la ansiedad, depresion y epilepsia. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7351700B2 (de) |
| EP (1) | EP1725239B1 (de) |
| JP (1) | JP4563447B2 (de) |
| KR (1) | KR100802863B1 (de) |
| CN (1) | CN1925859B (de) |
| AT (1) | ATE367163T1 (de) |
| AU (1) | AU2005229505B2 (de) |
| BR (1) | BRPI0508310A (de) |
| CA (1) | CA2557719A1 (de) |
| DE (1) | DE602005001696T2 (de) |
| ES (1) | ES2290885T3 (de) |
| PL (1) | PL1725239T3 (de) |
| RU (1) | RU2382033C2 (de) |
| WO (1) | WO2005094828A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2353619C2 (ru) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические композиции на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции |
| RU2354647C2 (ru) * | 2007-06-28 | 2009-05-10 | Общество С Ограниченной Ответственностью "Бионика" | Новые соединения, обладающие функцией ингибиторов тромбина, и фармацевтические композиции на их основе |
| EP2074118A2 (de) * | 2007-07-09 | 2009-07-01 | AstraZeneca AB | Trisubstituierte pyrimidinderivate zur behandlung proliferativer erkrankungen |
| TW201623257A (zh) | 2014-05-09 | 2016-07-01 | 奧利安公司 | 藥理活性之喹唑啉二酮衍生物 |
| KR102269132B1 (ko) | 2014-06-10 | 2021-06-25 | 삼성디스플레이 주식회사 | 반방향족성 화합물 및 이를 포함하는 유기 발광 소자 |
| US10084141B2 (en) | 2014-06-13 | 2018-09-25 | Samsung Display Co., Ltd. | Antiaromatic compound and organic light-emitting device including the same |
| HU231058B1 (hu) | 2017-03-13 | 2020-04-28 | Richter Gedeon Nyrt. | Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| CN116075514A (zh) | 2020-08-05 | 2023-05-05 | 吉瑞工厂 | 药理学活性的杂环取代的吡唑并[1,5-a]嘧啶衍生物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313146B1 (en) | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| RU2153494C2 (ru) * | 1993-10-12 | 2000-07-27 | Дзе Дюпон Мерк Фармасьютикал Компани | 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция |
| US6800651B2 (en) | 2000-02-03 | 2004-10-05 | Eli Lilly And Company | Potentiators of glutamate receptors |
| EP1385831A2 (de) * | 2001-04-11 | 2004-02-04 | Queen's University At Kingston | Pyrimidderivate zur behandlung von epilepsie |
| GB0209481D0 (en) | 2002-04-24 | 2002-06-05 | Novartis Ag | Organic compounds |
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2005
- 2005-02-22 AT AT05707562T patent/ATE367163T1/de active
- 2005-02-22 KR KR1020067017683A patent/KR100802863B1/ko not_active Expired - Fee Related
- 2005-02-22 WO PCT/EP2005/001814 patent/WO2005094828A1/en not_active Ceased
- 2005-02-22 JP JP2007501167A patent/JP4563447B2/ja not_active Expired - Fee Related
- 2005-02-22 ES ES05707562T patent/ES2290885T3/es not_active Expired - Lifetime
- 2005-02-22 RU RU2006134632/04A patent/RU2382033C2/ru not_active IP Right Cessation
- 2005-02-22 AU AU2005229505A patent/AU2005229505B2/en not_active Ceased
- 2005-02-22 PL PL05707562T patent/PL1725239T3/pl unknown
- 2005-02-22 EP EP05707562A patent/EP1725239B1/de not_active Expired - Lifetime
- 2005-02-22 CN CN2005800066192A patent/CN1925859B/zh not_active Expired - Fee Related
- 2005-02-22 DE DE602005001696T patent/DE602005001696T2/de not_active Expired - Lifetime
- 2005-02-22 BR BRPI0508310-9A patent/BRPI0508310A/pt not_active IP Right Cessation
- 2005-02-22 CA CA002557719A patent/CA2557719A1/en not_active Abandoned
- 2005-02-23 US US11/064,046 patent/US7351700B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005229505B2 (en) | 2010-07-15 |
| CN1925859A (zh) | 2007-03-07 |
| JP2007526266A (ja) | 2007-09-13 |
| JP4563447B2 (ja) | 2010-10-13 |
| KR20060116240A (ko) | 2006-11-14 |
| US20050197337A1 (en) | 2005-09-08 |
| EP1725239B1 (de) | 2007-07-18 |
| DE602005001696D1 (de) | 2007-08-30 |
| BRPI0508310A (pt) | 2007-07-24 |
| RU2006134632A (ru) | 2008-04-10 |
| CA2557719A1 (en) | 2005-10-13 |
| US7351700B2 (en) | 2008-04-01 |
| KR100802863B1 (ko) | 2008-02-12 |
| CN1925859B (zh) | 2010-11-24 |
| EP1725239A1 (de) | 2006-11-29 |
| WO2005094828A1 (en) | 2005-10-13 |
| RU2382033C2 (ru) | 2010-02-20 |
| ATE367163T1 (de) | 2007-08-15 |
| PL1725239T3 (pl) | 2007-12-31 |
| DE602005001696T2 (de) | 2008-04-10 |
| AU2005229505A1 (en) | 2005-10-13 |
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