ES2285768T5 - Proteínas crsp (proteínas segregadas ricas en cisteína), moléculas de ácido nucleico que codifican para las mismas y uso. - Google Patents
Proteínas crsp (proteínas segregadas ricas en cisteína), moléculas de ácido nucleico que codifican para las mismas y uso. Download PDFInfo
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- ES2285768T5 ES2285768T5 ES98918453T ES98918453T ES2285768T5 ES 2285768 T5 ES2285768 T5 ES 2285768T5 ES 98918453 T ES98918453 T ES 98918453T ES 98918453 T ES98918453 T ES 98918453T ES 2285768 T5 ES2285768 T5 ES 2285768T5
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84370497A | 1997-04-16 | 1997-04-16 | |
| US843704 | 1997-04-16 | ||
| US84289897A | 1997-04-17 | 1997-04-17 | |
| US842898 | 1997-04-17 | ||
| US7158998P | 1998-01-15 | 1998-01-15 | |
| US71589P | 1998-01-15 | ||
| US980298A | 1998-01-20 | 1998-01-20 | |
| US9802 | 1998-01-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2285768T3 ES2285768T3 (es) | 2007-11-16 |
| ES2285768T5 true ES2285768T5 (es) | 2011-12-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98918453T Expired - Lifetime ES2285768T5 (es) | 1997-04-16 | 1998-04-16 | Proteínas crsp (proteínas segregadas ricas en cisteína), moléculas de ácido nucleico que codifican para las mismas y uso. |
Country Status (11)
| Country | Link |
|---|---|
| EP (3) | EP0975755B2 (enExample) |
| JP (4) | JP2001524824A (enExample) |
| AT (2) | ATE505543T1 (enExample) |
| AU (2) | AU7137398A (enExample) |
| CA (1) | CA2288430C (enExample) |
| CY (1) | CY1107629T1 (enExample) |
| DE (2) | DE69837085T3 (enExample) |
| DK (1) | DK0975755T3 (enExample) |
| ES (1) | ES2285768T5 (enExample) |
| PT (1) | PT975755E (enExample) |
| WO (1) | WO1998046755A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7057017B2 (en) | 1997-04-16 | 2006-06-06 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| AU8555098A (en) * | 1997-08-01 | 1999-02-22 | Genset | 5' ests for secreted proteins expressed in testis and other tissues |
| DE19747418C1 (de) | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| US7446181B2 (en) | 1998-01-15 | 2008-11-04 | Millennium Pharmaceuticals, Inc. | Antibodies that bind human Dickkopf-1 proteins |
| US6344541B1 (en) * | 1998-09-25 | 2002-02-05 | Amgen Inc. | DKR polypeptides |
| CN1197965C (zh) * | 1998-10-26 | 2005-04-20 | 诺维信公司 | 在丝状真菌细胞内构建和筛选目的dna文库 |
| WO2000052047A2 (en) * | 1999-03-05 | 2000-09-08 | Millennium Pharmaceuticals, Inc. | Human dickkopf-related protein and nucleic acid molecules and uses therefor |
| US7115665B1 (en) | 2000-11-16 | 2006-10-03 | Onocozyme Pharma, Inc. | Inhibitors of endo-exonuclease activity for treating cancer |
| CN1402784A (zh) | 1999-11-19 | 2003-03-12 | 久光制药株式会社 | 细胞增殖抑制蛋白质、多核苷酸、与多核苷酸对应的反义核苷酸,以及细胞增殖抑制剂、癌症诊断试剂、癌症治疗剂和用于基因治疗的组合物 |
| EP1224471B1 (en) * | 2000-02-24 | 2003-11-26 | Oxford GlycoSciences (UK) Limited | Dpi-6, a therapeutic biomarker in neurological disorders |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| US7927597B2 (en) | 2001-04-10 | 2011-04-19 | Agensys, Inc. | Methods to inhibit cell growth |
| AU2002308557A1 (en) | 2001-05-01 | 2002-11-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
| US20040038860A1 (en) | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| WO2005049640A2 (en) | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof |
| US7473770B2 (en) | 2003-11-17 | 2009-01-06 | Merck & Co., Inc. | Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof |
| WO2005095448A2 (en) | 2004-03-23 | 2005-10-13 | Oscient Pharmaceuticals Corporation | Method of synthesizing and purifying dkk proteins and dkk proteins obtained thereby |
| ES2414460T3 (es) | 2004-08-04 | 2013-07-19 | Amgen Inc. | Anticuerpos para Dkk-1 |
| AR060017A1 (es) | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
| US7465585B1 (en) * | 2006-04-10 | 2008-12-16 | The Burnham Institute | Compositions and methods for inhibiting cell migration |
| AR075989A1 (es) | 2009-04-10 | 2011-05-11 | Lilly Co Eli | Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JP2874751B2 (ja) | 1986-04-09 | 1999-03-24 | ジェンザイム・コーポレーション | 希望する蛋白質をミルク中へ分泌する遺伝子移植動物 |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP1997891A1 (en) | 1988-09-02 | 2008-12-03 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| DE69033493D1 (de) | 1989-07-25 | 2004-08-12 | Cell Genesys Inc | Homologe rekombination für universelle donorzellen und chimerische säugetierzellen |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| IL98764A0 (en) | 1990-07-10 | 1992-07-15 | Smithkline Beecham Corp | Oxamides |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU9076191A (en) | 1990-11-21 | 1992-06-25 | Massachusetts Institute Of Technology | Mice having beta 2 microglobulin gene disruption |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ATE439435T1 (de) | 1991-03-01 | 2009-08-15 | Dyax Corp | Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon |
| DE69233750D1 (de) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Bibliotheken heterodimerer Rezeptoren mittels Phagemiden |
| DK0606217T4 (da) | 1991-06-27 | 2009-03-30 | Bristol Myers Squibb Co | CTL4-receptor, fusionsproteiner indeholdende den samt anvendelse deraf |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| DE69333366T2 (de) | 1992-10-30 | 2004-09-16 | The General Hospital Corp., Boston | Ein neues zellzyklus kontrollprotein |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| JP2879303B2 (ja) * | 1993-01-14 | 1999-04-05 | 佑 本庶 | ｃＤＮＡライブラリーの作製方法、および新規なポリペプチドとそれをコードするＤＮＡ |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| AU5613498A (en) * | 1996-12-20 | 1998-07-17 | Human Genome Sciences, Inc. | Cerebellum and embryo specific protein |
| DE19747418C1 (de) * | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
-
1998
- 1998-04-16 AT AT06021943T patent/ATE505543T1/de not_active IP Right Cessation
- 1998-04-16 EP EP98918453A patent/EP0975755B2/en not_active Expired - Lifetime
- 1998-04-16 DE DE69837085T patent/DE69837085T3/de not_active Expired - Lifetime
- 1998-04-16 JP JP54436198A patent/JP2001524824A/ja active Pending
- 1998-04-16 WO PCT/US1998/007894 patent/WO1998046755A1/en not_active Ceased
- 1998-04-16 DE DE69842225T patent/DE69842225D1/de not_active Expired - Lifetime
- 1998-04-16 AU AU71373/98A patent/AU7137398A/en not_active Abandoned
- 1998-04-16 EP EP10010403A patent/EP2298899A3/en not_active Withdrawn
- 1998-04-16 ES ES98918453T patent/ES2285768T5/es not_active Expired - Lifetime
- 1998-04-16 EP EP06021943A patent/EP1852507B1/en not_active Expired - Lifetime
- 1998-04-16 PT PT98918453T patent/PT975755E/pt unknown
- 1998-04-16 AT AT98918453T patent/ATE353964T1/de active
- 1998-04-16 DK DK98918453T patent/DK0975755T3/da active
- 1998-04-16 CA CA2288430A patent/CA2288430C/en not_active Expired - Lifetime
-
2005
- 2005-12-22 JP JP2005370262A patent/JP2006166917A/ja active Pending
-
2007
- 2007-05-14 CY CY20071100650T patent/CY1107629T1/el unknown
-
2009
- 2009-08-17 JP JP2009188614A patent/JP2010011853A/ja active Pending
- 2009-10-22 AU AU2009227915A patent/AU2009227915A1/en not_active Abandoned
-
2010
- 2010-05-13 JP JP2010111163A patent/JP2010227110A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE505543T1 (de) | 2011-04-15 |
| JP2010227110A (ja) | 2010-10-14 |
| EP0975755B1 (en) | 2007-02-14 |
| EP0975755A1 (en) | 2000-02-02 |
| EP2298899A3 (en) | 2011-08-24 |
| EP2298899A2 (en) | 2011-03-23 |
| DK0975755T3 (da) | 2007-06-11 |
| PT975755E (pt) | 2007-06-26 |
| ATE353964T1 (de) | 2007-03-15 |
| JP2001524824A (ja) | 2001-12-04 |
| WO1998046755A1 (en) | 1998-10-22 |
| CY1107629T1 (el) | 2013-06-19 |
| JP2010011853A (ja) | 2010-01-21 |
| CA2288430A1 (en) | 1998-10-22 |
| DE69837085D1 (de) | 2007-03-29 |
| AU7137398A (en) | 1998-11-11 |
| AU2009227915A1 (en) | 2009-11-12 |
| DE69837085T3 (de) | 2012-01-12 |
| EP1852507A1 (en) | 2007-11-07 |
| EP0975755B2 (en) | 2011-08-03 |
| DE69842225D1 (de) | 2011-05-26 |
| CA2288430C (en) | 2013-04-09 |
| EP0975755B9 (en) | 2007-08-29 |
| ES2285768T3 (es) | 2007-11-16 |
| JP2006166917A (ja) | 2006-06-29 |
| EP1852507B1 (en) | 2011-04-13 |
| DE69837085T2 (de) | 2007-11-22 |
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