ES2278078T3 - Derivados de triazepina como agentes neurotroficos. - Google Patents
Derivados de triazepina como agentes neurotroficos. Download PDFInfo
- Publication number
- ES2278078T3 ES2278078T3 ES02800474T ES02800474T ES2278078T3 ES 2278078 T3 ES2278078 T3 ES 2278078T3 ES 02800474 T ES02800474 T ES 02800474T ES 02800474 T ES02800474 T ES 02800474T ES 2278078 T3 ES2278078 T3 ES 2278078T3
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- Prior art keywords
- compound
- acid
- alkyl
- compounds
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 150000001875 compounds Chemical class 0.000 claims abstract description 60
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- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 125000005842 heteroatom Chemical group 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 11
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- 238000002360 preparation method Methods 0.000 claims description 9
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32692701P | 2001-10-04 | 2001-10-04 | |
| US326927P | 2001-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2278078T3 true ES2278078T3 (es) | 2007-08-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02800474T Expired - Lifetime ES2278078T3 (es) | 2001-10-04 | 2002-10-04 | Derivados de triazepina como agentes neurotroficos. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1446127B1 (enExample) |
| JP (1) | JP2005504823A (enExample) |
| AT (1) | ATE347893T1 (enExample) |
| AU (1) | AU2002334837B2 (enExample) |
| CA (1) | CA2462643A1 (enExample) |
| DE (1) | DE60216807T2 (enExample) |
| ES (1) | ES2278078T3 (enExample) |
| MX (1) | MXPA04003215A (enExample) |
| WO (1) | WO2003028734A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1240691C (zh) * | 2001-12-06 | 2006-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代五元氮杂环类化合物及其预防和治疗神经退行性疾病的用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| FR1511147A (fr) * | 1966-12-16 | 1968-01-26 | Soc Ind Fab Antibiotiques Sifa | Nouveaux dérivés de la 11 h-dibenzotriazépine-1, 2, 5 et leurs sels, et procédéde préparation |
-
2002
- 2002-10-04 WO PCT/US2002/031679 patent/WO2003028734A1/en not_active Ceased
- 2002-10-04 MX MXPA04003215A patent/MXPA04003215A/es active IP Right Grant
- 2002-10-04 AU AU2002334837A patent/AU2002334837B2/en not_active Ceased
- 2002-10-04 AT AT02800474T patent/ATE347893T1/de not_active IP Right Cessation
- 2002-10-04 CA CA002462643A patent/CA2462643A1/en not_active Abandoned
- 2002-10-04 EP EP02800474A patent/EP1446127B1/en not_active Expired - Lifetime
- 2002-10-04 DE DE60216807T patent/DE60216807T2/de not_active Expired - Lifetime
- 2002-10-04 ES ES02800474T patent/ES2278078T3/es not_active Expired - Lifetime
- 2002-10-04 JP JP2003532066A patent/JP2005504823A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1446127B1 (en) | 2006-12-13 |
| CA2462643A1 (en) | 2003-04-10 |
| EP1446127A1 (en) | 2004-08-18 |
| ATE347893T1 (de) | 2007-01-15 |
| MXPA04003215A (es) | 2005-01-25 |
| DE60216807T2 (de) | 2007-10-04 |
| JP2005504823A (ja) | 2005-02-17 |
| AU2002334837B2 (en) | 2007-03-15 |
| DE60216807D1 (de) | 2007-01-25 |
| WO2003028734A1 (en) | 2003-04-10 |
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