ES2268735T3 - Metodos y composiciones para la deteccion de cancer cervical. - Google Patents

Metodos y composiciones para la deteccion de cancer cervical. Download PDF

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Publication number
ES2268735T3
ES2268735T3 ES97938400T ES97938400T ES2268735T3 ES 2268735 T3 ES2268735 T3 ES 2268735T3 ES 97938400 T ES97938400 T ES 97938400T ES 97938400 T ES97938400 T ES 97938400T ES 2268735 T3 ES2268735 T3 ES 2268735T3
Authority
ES
Spain
Prior art keywords
seq
baselineskip
protein
cervical cancer
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97938400T
Other languages
English (en)
Spanish (es)
Inventor
Susan K. Keesee
Robert Obar
Ying-Jye Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Matritech Inc
Original Assignee
Matritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matritech Inc filed Critical Matritech Inc
Application granted granted Critical
Publication of ES2268735T3 publication Critical patent/ES2268735T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57411Specifically defined cancers of cervix
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES97938400T 1996-08-30 1997-08-19 Metodos y composiciones para la deteccion de cancer cervical. Expired - Lifetime ES2268735T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US705660 1991-05-24
US08/705,660 US5858683A (en) 1996-08-30 1996-08-30 Methods and compositions for the detection of cervical cancer

Publications (1)

Publication Number Publication Date
ES2268735T3 true ES2268735T3 (es) 2007-03-16

Family

ID=24834422

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97938400T Expired - Lifetime ES2268735T3 (es) 1996-08-30 1997-08-19 Metodos y composiciones para la deteccion de cancer cervical.

Country Status (9)

Country Link
US (4) US5858683A (enExample)
EP (1) EP0923740B1 (enExample)
JP (1) JP4116082B2 (enExample)
AT (1) ATE332505T1 (enExample)
AU (1) AU4073297A (enExample)
CA (1) CA2263888C (enExample)
DE (1) DE69736293T2 (enExample)
ES (1) ES2268735T3 (enExample)
WO (1) WO1998009170A2 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303323B1 (en) 1997-10-21 2001-10-16 Cancer Research Campaign Technology Limited Detection of dysplastic or neoplastic cells using anti-MCM5 antibodies
CO5080817A1 (es) * 1997-10-21 2001-09-25 Cancer Res Campaign Tech Ltd Determinacion de anormalidades en el crecimiento celular
GB9805477D0 (en) * 1998-03-13 1998-05-13 Oxford Glycosciences Limited Methods and compositions for diagnosis of rheumatoid arthritis
DE19829473C2 (de) * 1998-07-01 2000-08-10 Magnus Von Knebel Doeberitz Ch Verfahren zur frühen Diagnose von Carcinomen
EP1388734B1 (en) * 2002-08-01 2004-03-03 MTM Laboratories AG Method for solution based diagnosis
US7306926B2 (en) * 1998-07-01 2007-12-11 Mtm Laboratories Ag Method for detecting carcinomas in a solubilized cervical body sample
DE19855819C2 (de) * 1998-12-03 2001-02-15 Roche Diagnostics Gmbh Stabilisierung von Cytokeratin enthaltenden Kalibratoren
US6294349B1 (en) 1999-03-01 2001-09-25 University Of Mississippi Medical Ctr. Method of diagnosing and monitoring malignant breast carcinomas
US6379970B1 (en) * 1999-04-30 2002-04-30 The Arizona Board Of Regents On Behalf Of The University Of Arizona Analysis of differential protein expression
IL146374A0 (en) 1999-05-17 2002-07-25 Pro Duct Health Inc Identifying material from a breast duct
AU5897600A (en) * 1999-06-29 2001-01-31 Intercet, Ltd. Human cancer virtual simulation system
AU2074101A (en) * 1999-12-08 2001-06-18 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
WO2001042467A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
AU2001288501A1 (en) * 2000-09-01 2002-03-22 Large Scale Proteomics Corporation Reference database
US6980674B2 (en) * 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
US6539102B1 (en) * 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
EP1202211A3 (en) * 2000-10-26 2004-12-22 Riken Genomic DNA analysis computer program
KR100426453B1 (ko) 2000-11-28 2004-04-13 김진우 인간 자궁경부암 2 원암 유전자 및 이에 의해 코딩되는단백질, 이를 포함하는 발현벡터 및 이 벡터로 형질전환된세포
KR100426454B1 (ko) * 2000-11-28 2004-04-13 김진우 인간 원암 유전자 및 이에 의해 코드되는 단백질
US20030009293A1 (en) * 2001-01-09 2003-01-09 Anderson Norman G. Reference database
AUPR595601A0 (en) * 2001-06-27 2001-07-19 International Diabetes Institute Hypoglycaemic peptides and methods of use thereof
KR100472746B1 (ko) * 2001-08-13 2005-03-07 김진우 원암 유전자 kg-20 및 이에 의해 코드되는 단백질
US20030138425A1 (en) * 2001-09-21 2003-07-24 Mather Jennie Powell Antibodies that bind to cancer-associated antigen cytokeratin 8 and methods of use thereof
US7306925B2 (en) * 2001-11-09 2007-12-11 Vanderbilt University Phage antibodies to radiation-inducible neoantigens
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
EP1333278B1 (en) 2002-02-01 2004-03-10 MTM molecular tools in medicine Methods for monitoring and prognosis of disease course of gastrointestinal tumors
KR100472747B1 (ko) * 2002-03-12 2005-03-09 김진우 인간 원암 유전자 및 이에 의해 코드되는 단백질
EP1369694A1 (en) 2002-04-09 2003-12-10 MTM Laboratories AG Method for discrimination of metaplasias from neoplastic or preneoplastic lesions
DE60229920D1 (de) * 2002-05-21 2009-01-02 Mtm Lab Ag Marker für Lungentumore
KR20030094905A (ko) * 2002-06-10 2003-12-18 김진우 생쥐 발암유전자, 이에 의해 코드되는 단백질 및 이를포함하는 발현벡터
WO2004003203A1 (en) * 2002-06-29 2004-01-08 Jin-Woo Kim Human cervical cancer 5 protooncogene and protein encoded therein
AU2002345414A1 (en) * 2002-07-04 2004-01-23 Jin Woo Kim Human protooncogene 6 and protein encoded therein
EP1422526A1 (en) * 2002-10-28 2004-05-26 MTM Laboratories AG Method for improved diagnosis of dysplasias
US20040137551A1 (en) * 2003-01-13 2004-07-15 Markovic Nenad S. Cervical acid phosphatase - papanicolaou (CAP-PAP) test kit, method and accesories, processes for producing and using the same
US7291699B2 (en) * 2003-03-18 2007-11-06 The Regents Of The University Of Colorado Product and methods for diagnosis and therapy for cardiac and skeletal muscle disorders
US7361460B2 (en) * 2003-04-11 2008-04-22 Digene Corporation Approach to molecular diagnosis of human papillomavirus-related diseases
ATE289685T1 (de) * 2003-08-25 2005-03-15 Mtm Lab Ag Verfahren zum nachweis von karzinomen in solubilisierten zervikalen körperproben
US20070134742A1 (en) * 2003-10-30 2007-06-14 Koichi Nakano Diagnostic reagent for uterine adenocarcinoma and method of detecting adenocarcinoma cells
WO2005054548A2 (en) 2003-11-28 2005-06-16 Invitrogen Corporation Methods, compositions, and kits for protein crystallization
EP1756577B1 (en) * 2004-03-24 2012-03-14 Tripath Imaging, Inc. Methods and compositions for the detection of cervical disease
CN1677109A (zh) * 2004-03-30 2005-10-05 希森美康株式会社 子宫颈癌的筛选方法
US7183057B2 (en) * 2004-03-31 2007-02-27 Dermtech International Tape stripping methods for analysis of skin disease and pathological skin state
US7316904B1 (en) 2004-06-30 2008-01-08 Chromodynamics, Inc. Automated pap screening using optical detection of HPV with or without multispectral imaging
JP5855326B2 (ja) 2005-01-06 2016-02-09 ノヴォ ノルディスク アー/エス 抗kir組み合わせ治療および方法
KR100689275B1 (ko) 2005-03-30 2007-03-08 김현기 인간 원암유전자 trg 및 이에 의해 코드되는 단백질
US7595380B2 (en) * 2005-04-27 2009-09-29 Tripath Imaging, Inc. Monoclonal antibodies and methods for their use in the detection of cervical disease
US20070015166A1 (en) * 2005-07-14 2007-01-18 Nilsen Thor W Lateral flow methods and devices for detection of nucleic acid binding proteins
US7632498B2 (en) 2005-12-19 2009-12-15 Tripath Imaging, Inc. MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease
US8012678B2 (en) * 2007-07-24 2011-09-06 Wisconsin Alumni Research Foundation Biomarkers for human papilloma virus-associated cancer
CA2724322C (en) 2008-05-14 2019-07-16 Dermtech International Diagnosis of melanoma and solar lentigo by nucleic acid analysis
WO2012065004A2 (en) * 2010-11-12 2012-05-18 Incelldx, Inc. Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells
WO2013019730A1 (en) 2011-07-29 2013-02-07 The Washington University Antibodies to tip-1 and grp78
CN110527728A (zh) * 2013-08-08 2019-12-03 纽约州州立大学研究基金会 作为子宫颈癌和存活期的生物标记物的角蛋白
EP3172222A4 (en) 2014-07-24 2018-03-21 Washington University Compositions targeting radiation-induced molecules and methods of use thereof
CN109563130A (zh) * 2016-04-07 2019-04-02 卡斯西部储备大学 用于治疗神经退行性疾病的tdp-43线粒体定位抑制剂
US11352436B2 (en) 2017-02-10 2022-06-07 Washington University Antibodies to TIP1 and methods of use thereof
EP3752645A4 (en) 2018-02-14 2022-04-13 Dermtech, Inc. Novel gene classifiers and uses thereof in non-melanoma skin cancers
AU2020247911A1 (en) 2019-03-26 2021-11-11 Dermtech, Llc Novel gene classifiers and uses thereof in skin cancers

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56145222A (en) * 1980-04-28 1981-11-11 Toshiyuki Hamaoka Improved antibody and its preparation
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
JP2723203B2 (ja) * 1984-01-06 1998-03-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア サイトケラチン腫瘍マーカー及びそれらの検出のためのアッセイ
JPS6284100A (ja) * 1985-10-08 1987-04-17 Dainabotsuto Kk 扁平上皮癌関連抗原に対する抗体及びその免疫学的利用法
US5273877A (en) * 1985-12-24 1993-12-28 Massachusetts Institute Of Technology Non-histological cell type determination
US4882268A (en) * 1985-12-24 1989-11-21 Massachusetts Institute Of Technology Method for determining tissue of origin and degree of malignancy of tumor cells
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5098890A (en) * 1988-11-07 1992-03-24 Temple University-Of The Commonwealth System Of Higher Education Antisence oligonucleotides to c-myb proto-oncogene and uses thereof
CA1340245C (en) * 1989-04-21 1998-12-15 John Samuel Monoclonal antibody for differentiation of squamous cell carcinoma antigens and method of use for same
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
CA2122473C (en) * 1991-10-31 2001-01-23 Lee Anne Beausang Nuclear matrix protein fluid assay
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
US5688511A (en) * 1991-11-05 1997-11-18 Board Of Regents, The University Of Texas System Cellular protein TDP-43 and regulation of HIV-1 gene expression
CA2138807A1 (en) * 1992-06-22 1994-01-06 Gary Toukatly Novel malignant cell type markers of the interior nuclear matrix
WO1994012881A2 (en) * 1992-12-02 1994-06-09 Hochstrasser Denis F A METHOD FOR DETECTING GROWING CELLS USING TRANSLATIONALLY CONTROLLED TUMOR PROTEIN p21
US5547928A (en) * 1993-12-17 1996-08-20 Matritech, Inc. Methods and compositions for the detection of colon cancers
US5519003A (en) * 1994-02-01 1996-05-21 Board Of Trustees Of The Leland Stanford Junior University WD-40-derived peptides and uses thereof

Also Published As

Publication number Publication date
EP0923740A2 (en) 1999-06-23
CA2263888C (en) 2004-10-26
US20050164313A1 (en) 2005-07-28
DE69736293T2 (de) 2007-06-14
US5858683A (en) 1999-01-12
US20030157482A1 (en) 2003-08-21
JP4116082B2 (ja) 2008-07-09
US6027905A (en) 2000-02-22
ATE332505T1 (de) 2006-07-15
JP2001500609A (ja) 2001-01-16
WO1998009170A3 (en) 1998-04-23
EP0923740B1 (en) 2006-07-05
WO1998009170A2 (en) 1998-03-05
AU4073297A (en) 1998-03-19
US6803189B2 (en) 2004-10-12
CA2263888A1 (en) 1998-03-05
DE69736293D1 (de) 2006-08-17

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