ES2240740T3 - Metodo para proporcionar latencia a agentes farmaceuticamente activos. - Google Patents
Metodo para proporcionar latencia a agentes farmaceuticamente activos.Info
- Publication number
- ES2240740T3 ES2240740T3 ES02729440T ES02729440T ES2240740T3 ES 2240740 T3 ES2240740 T3 ES 2240740T3 ES 02729440 T ES02729440 T ES 02729440T ES 02729440 T ES02729440 T ES 02729440T ES 2240740 T3 ES2240740 T3 ES 2240740T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- lap
- nucleic acid
- fusion protein
- mmp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/756,283 US6942853B2 (en) | 2001-01-09 | 2001-01-09 | Latent fusion protein |
| GBGB0100551.1A GB0100551D0 (en) | 2001-01-09 | 2001-01-09 | Protein |
| GB0100551 | 2001-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2240740T3 true ES2240740T3 (es) | 2005-10-16 |
Family
ID=26245544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02729440T Expired - Lifetime ES2240740T3 (es) | 2001-01-09 | 2002-01-09 | Metodo para proporcionar latencia a agentes farmaceuticamente activos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6942853B2 (https=) |
| EP (1) | EP1349944B1 (https=) |
| JP (1) | JP4201253B2 (https=) |
| AT (1) | ATE293169T1 (https=) |
| AU (1) | AU2002219345B2 (https=) |
| DE (1) | DE60203692T2 (https=) |
| DK (1) | DK1349944T3 (https=) |
| ES (1) | ES2240740T3 (https=) |
| GB (1) | GB0100551D0 (https=) |
| WO (1) | WO2002055098A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141392B2 (en) * | 2001-01-09 | 2006-11-28 | Queen Mary And Westfield College | Latent fusion protein |
| US20030219402A1 (en) * | 2002-02-14 | 2003-11-27 | Rutter William J. | Chimeric molecules for cleavage in a treated host |
| JP2009510166A (ja) * | 2005-10-04 | 2009-03-12 | グリーンビル ホスピタル システム | 潜伏性プロサイトトキシンおよびそれらの用途 |
| DE102006009324A1 (de) | 2006-03-01 | 2007-09-06 | Dr.Ing.H.C. F. Porsche Ag | Verfahren und Steuergerät zur Steuerung eines variablen Turbolader-Turbinenströmungsquerschnitts |
| WO2008130382A2 (en) | 2006-10-31 | 2008-10-30 | East Carolina University | Fusion proteins comprising an anti -inflammatory cytokine and an antigen for treatment of immune disorders |
| GB0724556D0 (en) * | 2007-12-17 | 2008-01-30 | Queen Mary & Westfield College | LAtency associated protein construct with aggrecanase sensitive cleavage site |
| FR2932190A1 (fr) * | 2008-06-10 | 2009-12-11 | Commissariat Energie Atomique | Peptides cycliques fluorescents, procedes de preparation de ceux-ci et utilisation de ces peptides pour mesurer l'activite enzymatique d'une enzyme protease |
| CA2757287C (en) | 2009-03-31 | 2019-09-10 | East Carolina University | Cytokines and neuroantigens for treatment of immune disorders |
| GB0911365D0 (en) | 2009-06-30 | 2009-08-12 | Bioceramic Therapeutics Ltd | Multicomponent glasses for use as coatings and in personal care products |
| EP2553101A4 (en) * | 2010-04-02 | 2013-09-04 | Univ Rochester | PROTEASE-ACTIVATED CYTOKINES |
| EP2878308B1 (en) * | 2013-12-02 | 2018-10-31 | Thomas Harder | Agents and methods for the suppression of T cell activation |
| GB201411506D0 (en) * | 2014-06-27 | 2014-08-13 | Univ London Queen Mary | Modified latency associated protein construct |
| JP6516235B2 (ja) * | 2014-10-31 | 2019-05-22 | 国立大学法人富山大学 | キメラタンパク質及びそれを用いたミクログリア活性阻害剤 |
| CA3100005A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| AU2019271148B9 (en) | 2018-05-14 | 2025-05-29 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| US12459980B2 (en) | 2018-07-25 | 2025-11-04 | AskGene Pharma, Inc. | IL-21 prodrugs and methods of use thereof |
| CN120463822A (zh) * | 2018-09-27 | 2025-08-12 | 西里欧发展公司 | 掩蔽型细胞因子多肽 |
| ES2780274A1 (es) * | 2019-02-15 | 2020-08-24 | Consejo Superior De Investig Científicas (Csic) | Cortistatina o un análogo de la misma como agente farmacéuticamente activo en forma latente |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| KR20220020879A (ko) | 2019-06-12 | 2022-02-21 | 에스크진 파마, 아이엔씨. | 새로운 il-15 프로드럭 및 이를 사용하는 방법 |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| WO2021142471A1 (en) | 2020-01-11 | 2021-07-15 | AskGene Pharma, Inc. | Novel masked cytokines and methods of use thereof |
| GB202004679D0 (en) | 2020-03-31 | 2020-05-13 | Stealthyx Therapeutics Ltd | Modified latercy associated protein construct |
| AU2021254283B2 (en) * | 2020-04-10 | 2025-12-11 | Cytomx Therapeutics, Inc. | Activatable cytokine constructs and related compositions and methods |
| WO2022115865A2 (en) | 2020-11-25 | 2022-06-02 | Xilio Development, Inc. | Tumor-specific cleavable linkers |
| JP2024511387A (ja) | 2021-03-16 | 2024-03-13 | シートムエックス セラピューティクス，インコーポレイテッド | マスクした活性化可能サイトカイン構成体ならびに関連する組成物及び方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284763A (en) | 1985-03-22 | 1994-02-08 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
| CA2003886A1 (en) | 1988-12-16 | 1990-06-16 | Anthony F. Purchio | Cloning and expression of simian transforming growth factor-beta 1 |
| ES2083469T3 (es) | 1989-11-22 | 1996-04-16 | Genentech Inc | Peptido asociado a una latencia y utilizaciones del mismo. |
| US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| BR9406715A (pt) | 1993-05-12 | 1996-02-06 | Genetics Inst | Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica |
| CA2712304C (en) | 1994-06-10 | 2011-10-25 | United States Surgical Corporation | Recombinant chimeric proteins and methods of use thereof |
| US5800811A (en) * | 1995-06-06 | 1998-09-01 | Hall; Frederick L. | Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site |
| CA2232669A1 (en) * | 1995-09-27 | 1997-04-03 | Frances Joanne Morling | Recombinant viruses incorporating a protease cleavable protein |
| DE19701141C1 (de) | 1997-01-16 | 1998-04-09 | Hoechst Ag | Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen |
| US6593132B1 (en) * | 1997-04-30 | 2003-07-15 | Twinstrand Therapeutics Inc. | Ricin-like toxin variants for treatment of cancer, viral or parasitic infections |
| GB2324960A (en) | 1997-05-09 | 1998-11-11 | Univ Manchester | Delivery of naked DNA for wound healing |
| JP3762222B2 (ja) | 1998-10-07 | 2006-04-05 | ストライカー・コーポレーション | 改変型ＴＧＦ−βスーパーファミリータンパク質 |
| JP2004508838A (ja) * | 2000-09-11 | 2004-03-25 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 組合せ蛍光エネルギー移動タグ及びそれらの使用 |
-
2001
- 2001-01-09 US US09/756,283 patent/US6942853B2/en not_active Expired - Lifetime
- 2001-01-09 GB GBGB0100551.1A patent/GB0100551D0/en not_active Ceased
-
2002
- 2002-01-09 WO PCT/GB2002/000068 patent/WO2002055098A2/en not_active Ceased
- 2002-01-09 ES ES02729440T patent/ES2240740T3/es not_active Expired - Lifetime
- 2002-01-09 JP JP2002555832A patent/JP4201253B2/ja not_active Expired - Fee Related
- 2002-01-09 AU AU2002219345A patent/AU2002219345B2/en not_active Ceased
- 2002-01-09 EP EP02729440A patent/EP1349944B1/en not_active Expired - Lifetime
- 2002-01-09 AT AT02729440T patent/ATE293169T1/de not_active IP Right Cessation
- 2002-01-09 DE DE60203692T patent/DE60203692T2/de not_active Expired - Lifetime
- 2002-01-09 DK DK02729440T patent/DK1349944T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| DK1349944T3 (da) | 2005-07-25 |
| DE60203692T2 (de) | 2006-03-02 |
| US6942853B2 (en) | 2005-09-13 |
| WO2002055098A2 (en) | 2002-07-18 |
| EP1349944A2 (en) | 2003-10-08 |
| WO2002055098A3 (en) | 2002-11-21 |
| EP1349944B1 (en) | 2005-04-13 |
| AU2002219345B2 (en) | 2006-03-16 |
| ATE293169T1 (de) | 2005-04-15 |
| DE60203692D1 (de) | 2005-05-19 |
| JP4201253B2 (ja) | 2008-12-24 |
| US20020151478A1 (en) | 2002-10-17 |
| GB0100551D0 (en) | 2001-02-21 |
| JP2004520031A (ja) | 2004-07-08 |
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