ES2231257T3 - Dispositivo para la administracion de farmacos. - Google Patents
Dispositivo para la administracion de farmacos.Info
- Publication number
- ES2231257T3 ES2231257T3 ES00961836T ES00961836T ES2231257T3 ES 2231257 T3 ES2231257 T3 ES 2231257T3 ES 00961836 T ES00961836 T ES 00961836T ES 00961836 T ES00961836 T ES 00961836T ES 2231257 T3 ES2231257 T3 ES 2231257T3
- Authority
- ES
- Spain
- Prior art keywords
- administration
- sclera
- pharmaceutically active
- ophthalmic device
- drugs according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000003786 sclera Anatomy 0.000 claims abstract description 57
- 239000013543 active substance Substances 0.000 claims abstract description 50
- 239000003814 drug Substances 0.000 claims abstract description 32
- 229940079593 drug Drugs 0.000 claims abstract description 32
- 210000001760 tenon capsule Anatomy 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 30
- 206010025421 Macule Diseases 0.000 claims description 11
- 239000000017 hydrogel Substances 0.000 claims description 11
- 230000014759 maintenance of location Effects 0.000 claims description 11
- 238000001647 drug administration Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 4
- GGUSQTSTQSHJAH-UHFFFAOYSA-N 1-(4-chlorophenyl)-2-[4-(4-fluorobenzyl)piperidin-1-yl]ethanol Chemical compound C=1C=C(Cl)C=CC=1C(O)CN(CC1)CCC1CC1=CC=C(F)C=C1 GGUSQTSTQSHJAH-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- 229950005455 eliprodil Drugs 0.000 claims description 2
- 239000013013 elastic material Substances 0.000 claims 1
- 210000001508 eye Anatomy 0.000 description 39
- 210000001519 tissue Anatomy 0.000 description 37
- 239000003826 tablet Substances 0.000 description 24
- 210000001525 retina Anatomy 0.000 description 21
- 206010064930 age-related macular degeneration Diseases 0.000 description 17
- 229920000642 polymer Polymers 0.000 description 17
- 238000011282 treatment Methods 0.000 description 17
- 239000007943 implant Substances 0.000 description 16
- 239000000203 mixture Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 14
- 210000003161 choroid Anatomy 0.000 description 12
- 208000005590 Choroidal Neovascularization Diseases 0.000 description 10
- 206010060823 Choroidal neovascularisation Diseases 0.000 description 10
- 230000000964 angiostatic effect Effects 0.000 description 8
- 150000003431 steroids Chemical class 0.000 description 8
- 206010038910 Retinitis Diseases 0.000 description 7
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- 206010038923 Retinopathy Diseases 0.000 description 6
- 206010046851 Uveitis Diseases 0.000 description 6
- 210000000795 conjunctiva Anatomy 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 6
- 208000010412 Glaucoma Diseases 0.000 description 5
- 208000001344 Macular Edema Diseases 0.000 description 5
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- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
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- 229940023490 ophthalmic product Drugs 0.000 description 5
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- 239000000725 suspension Substances 0.000 description 5
- 239000003732 agents acting on the eye Substances 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
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- 229920001296 polysiloxane Polymers 0.000 description 3
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- 230000002207 retinal effect Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 2
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- 208000036866 Vitreoretinopathy Diseases 0.000 description 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 description 2
- 230000001772 anti-angiogenic effect Effects 0.000 description 2
- 230000001384 anti-glaucoma Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000340 anti-metabolite Effects 0.000 description 2
- 229940100197 antimetabolite Drugs 0.000 description 2
- 239000002256 antimetabolite Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229920013641 bioerodible polymer Polymers 0.000 description 2
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- 210000003717 douglas' pouch Anatomy 0.000 description 2
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- 210000000744 eyelid Anatomy 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
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- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000006785 proliferative vitreoretinopathy Effects 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000001721 transfer moulding Methods 0.000 description 2
- 102000003846 Carbonic anhydrases Human genes 0.000 description 1
- 108090000209 Carbonic anhydrases Proteins 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 206010048843 Cytomegalovirus chorioretinitis Diseases 0.000 description 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- XYWMWLADMNOAAA-UHFFFAOYSA-N acetic acid;buta-1,3-diene Chemical compound CC(O)=O.C=CC=C XYWMWLADMNOAAA-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 239000000695 adrenergic alpha-agonist Substances 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
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- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229960003143 combination antiinfectives Drugs 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
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- 229920001577 copolymer Polymers 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 208000001763 cytomegalovirus retinitis Diseases 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 229940124581 decongestants Drugs 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 206010014801 endophthalmitis Diseases 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
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- 208000015181 infectious disease Diseases 0.000 description 1
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- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
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- 239000004090 neuroprotective agent Substances 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
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- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
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- 239000000734 parasympathomimetic agent Substances 0.000 description 1
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- 230000035699 permeability Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
- A61F2009/00891—Glaucoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16067399P | 1999-10-21 | 1999-10-21 | |
| US160673P | 1999-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2231257T3 true ES2231257T3 (es) | 2005-05-16 |
Family
ID=22577913
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00961836T Expired - Lifetime ES2231257T3 (es) | 1999-10-21 | 2000-09-12 | Dispositivo para la administracion de farmacos. |
| ES04018677T Expired - Lifetime ES2315598T3 (es) | 1999-10-21 | 2000-09-12 | Dispositivo para la administracion de farmacos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04018677T Expired - Lifetime ES2315598T3 (es) | 1999-10-21 | 2000-09-12 | Dispositivo para la administracion de farmacos. |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6413540B1 (enExample) |
| EP (2) | EP1473003B1 (enExample) |
| JP (1) | JP4837861B2 (enExample) |
| KR (1) | KR100732262B1 (enExample) |
| CN (1) | CN1292721C (enExample) |
| AR (3) | AR026165A1 (enExample) |
| AT (2) | ATE283013T1 (enExample) |
| AU (2) | AU768400B2 (enExample) |
| BR (1) | BR0014929B1 (enExample) |
| CA (1) | CA2383499C (enExample) |
| CY (1) | CY1109489T1 (enExample) |
| DE (2) | DE60016271T2 (enExample) |
| DK (1) | DK1473003T3 (enExample) |
| ES (2) | ES2231257T3 (enExample) |
| HK (1) | HK1048427B (enExample) |
| MX (1) | MXPA02002338A (enExample) |
| PL (1) | PL196988B1 (enExample) |
| PT (2) | PT1221917E (enExample) |
| TR (1) | TR200201047T2 (enExample) |
| TW (1) | TW555575B (enExample) |
| WO (1) | WO2001028472A1 (enExample) |
| ZA (2) | ZA200201188B (enExample) |
Families Citing this family (194)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2336703A1 (en) * | 1998-07-10 | 2000-01-20 | The University Of Sydney | Prophylactic treatments of neovascularisation in macular degeneration |
| TR200103098T2 (tr) | 1999-04-26 | 2002-04-22 | Gmp Vision Solutions, Inc. | Glokom tedavisi için döndürme aleti ve yöntemi. |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| KR100732262B1 (ko) * | 1999-10-21 | 2007-06-25 | 알콘, 인코퍼레이티드 | 약물 전달 장치 |
| US7943162B2 (en) | 1999-10-21 | 2011-05-17 | Alcon, Inc. | Drug delivery device |
| US20050119737A1 (en) * | 2000-01-12 | 2005-06-02 | Bene Eric A. | Ocular implant and methods for making and using same |
| US7708711B2 (en) | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
| US20020143284A1 (en) * | 2001-04-03 | 2002-10-03 | Hosheng Tu | Drug-releasing trabecular implant for glaucoma treatment |
| US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
| US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| JP2004517674A (ja) * | 2000-12-29 | 2004-06-17 | ボシュ・アンド・ロム・インコーポレイテッド | 徐放薬物送達装置 |
| WO2002053129A1 (en) * | 2001-01-03 | 2002-07-11 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with prefabricated permeable plugs |
| JP4184082B2 (ja) | 2001-01-03 | 2008-11-19 | ボシュ・アンド・ロム・インコーポレイテッド | 複数の薬剤を備えた徐放薬剤送達装置 |
| WO2002058667A2 (en) * | 2001-01-26 | 2002-08-01 | Bausch & Lomb Incorporated | Improved process for the production of sustained release drug delivery devices |
| US7488303B1 (en) * | 2002-09-21 | 2009-02-10 | Glaukos Corporation | Ocular implant with anchor and multiple openings |
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- 2000-09-12 PT PT00961836T patent/PT1221917E/pt unknown
- 2000-09-12 EP EP04018677A patent/EP1473003B1/en not_active Expired - Lifetime
- 2000-09-12 TR TR2002/01047T patent/TR200201047T2/xx unknown
- 2000-09-12 AT AT00961836T patent/ATE283013T1/de active
- 2000-09-12 DE DE60016271T patent/DE60016271T2/de not_active Expired - Lifetime
- 2000-09-12 PL PL355263A patent/PL196988B1/pl not_active IP Right Cessation
- 2000-09-12 EP EP00961836A patent/EP1221917B1/en not_active Expired - Lifetime
- 2000-09-12 CN CNB008131864A patent/CN1292721C/zh not_active Expired - Fee Related
- 2000-09-12 PT PT04018677T patent/PT1473003E/pt unknown
- 2000-09-12 DK DK04018677T patent/DK1473003T3/da active
- 2000-09-12 JP JP2001531069A patent/JP4837861B2/ja not_active Expired - Fee Related
- 2000-09-12 CA CA002383499A patent/CA2383499C/en not_active Expired - Fee Related
- 2000-09-12 AU AU73733/00A patent/AU768400B2/en not_active Ceased
- 2000-09-12 MX MXPA02002338A patent/MXPA02002338A/es active IP Right Grant
- 2000-09-12 ES ES00961836T patent/ES2231257T3/es not_active Expired - Lifetime
- 2000-09-12 BR BRPI0014929-2A patent/BR0014929B1/pt not_active IP Right Cessation
- 2000-09-12 HK HK02108313.1A patent/HK1048427B/en not_active IP Right Cessation
- 2000-09-12 AT AT04018677T patent/ATE414494T1/de active
- 2000-09-12 US US09/660,000 patent/US6413540B1/en not_active Expired - Lifetime
- 2000-09-12 WO PCT/US2000/024983 patent/WO2001028472A1/en not_active Ceased
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- 2000-09-12 ES ES04018677T patent/ES2315598T3/es not_active Expired - Lifetime
- 2000-10-03 AR ARP000105210A patent/AR026165A1/es active IP Right Grant
- 2000-10-05 TW TW089120788A patent/TW555575B/zh not_active IP Right Cessation
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- 2002-02-12 ZA ZA200201188A patent/ZA200201188B/en unknown
- 2002-02-12 ZA ZA200201189A patent/ZA200201189B/en unknown
- 2002-07-01 US US10/186,960 patent/US6808719B2/en not_active Expired - Lifetime
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- 2004-03-02 AU AU2004200908A patent/AU2004200908B2/en not_active Ceased
- 2004-10-04 US US10/957,910 patent/US20050112175A1/en not_active Abandoned
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