ES2220727T3 - Antagonistas del receptor metabotropico de glutamato para tratar la tolerancia y la dependencia. - Google Patents
Antagonistas del receptor metabotropico de glutamato para tratar la tolerancia y la dependencia.Info
- Publication number
- ES2220727T3 ES2220727T3 ES01910051T ES01910051T ES2220727T3 ES 2220727 T3 ES2220727 T3 ES 2220727T3 ES 01910051 T ES01910051 T ES 01910051T ES 01910051 T ES01910051 T ES 01910051T ES 2220727 T3 ES2220727 T3 ES 2220727T3
- Authority
- ES
- Spain
- Prior art keywords
- mglur5
- dependence
- treatment
- antagonist
- tolerance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- G—PHYSICS
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Landscapes
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| BR0314192A (pt) * | 2002-09-10 | 2005-07-26 | Novartis Ag | Antagonistas de receptores de mglu para tratamento de distúrbios associados com receptores de mglu incluindo vìcio e depressão |
| ES2819303T3 (es) | 2005-04-05 | 2021-04-15 | Univ Yale | Agentes moduladores del glutamato en el tratamiento de trastornos mentales |
| WO2006121919A2 (en) * | 2005-05-05 | 2006-11-16 | Massachusetts Institute Of Technology | Methods of treating obsessive compulsive disorder |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| WO2007035823A2 (en) * | 2005-09-20 | 2007-03-29 | Molecular Neuroimaging, Llc | Partial mglur5 antagonists and methods of use thereof |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| DE102005062985A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| DK2083811T3 (en) | 2006-11-22 | 2017-01-30 | Clinical Res Ass Llc | PROCEDURES FOR TREATING DOWNS SYNDROME, FRAGILT X SYNDROME AND AUTISM |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
| WO2011150380A1 (en) | 2010-05-28 | 2011-12-01 | Xenoport, Inc. | Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders |
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| WO2012054724A1 (en) | 2010-10-21 | 2012-04-26 | Massachusetts Institute Of Technology | Methods of treating seizure disorders |
| US20130123254A1 (en) * | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| AU2018310882C1 (en) | 2017-07-31 | 2021-12-09 | Novartis Ag | Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use |
| KR20200035035A (ko) * | 2017-07-31 | 2020-04-01 | 노파르티스 아게 | 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도 |
| JP7620694B2 (ja) * | 2020-07-17 | 2025-01-23 | ノバルティス アーゲー | オピオイド使用の低減用医薬品及びオピオイド禁断の促進用医薬品 |
| CA3204360A1 (en) * | 2020-12-14 | 2022-06-23 | Novartis Ag | Use of mglur5 antagonists for treating gambling disorder |
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| US5543698A (en) * | 1994-09-27 | 1996-08-06 | Allen-Bradley Company, Inc. | Method and apparatus used with AC motor for detecting unbalance |
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| US6666209B2 (en) * | 2001-02-20 | 2003-12-23 | 3M Innovative Properties Company | Method and system of calibrating air flow in a respirator system |
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| NZ521228A (en) | 2004-04-30 |
| HK1053262A1 (en) | 2003-10-17 |
| CA2402341A1 (en) | 2001-09-13 |
| WO2001066113A1 (en) | 2001-09-13 |
| DE60103384T2 (de) | 2005-06-16 |
| US20030195139A1 (en) | 2003-10-16 |
| EP1267869A1 (en) | 2003-01-02 |
| PT1267869E (pt) | 2004-10-29 |
| GB0005700D0 (en) | 2000-05-03 |
| EP1267869B1 (en) | 2004-05-19 |
| TR200401862T4 (tr) | 2004-10-21 |
| DE60103384D1 (de) | 2004-06-24 |
| DK1267869T3 (da) | 2004-09-20 |
| SE1267869T5 (cg-RX-API-DMAC10.html) | 2004-09-07 |
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