ES2210754T3 - Combinacion de analgesicos. - Google Patents
Combinacion de analgesicos.Info
- Publication number
- ES2210754T3 ES2210754T3 ES98921419T ES98921419T ES2210754T3 ES 2210754 T3 ES2210754 T3 ES 2210754T3 ES 98921419 T ES98921419 T ES 98921419T ES 98921419 T ES98921419 T ES 98921419T ES 2210754 T3 ES2210754 T3 ES 2210754T3
- Authority
- ES
- Spain
- Prior art keywords
- effect
- minutes
- analgesic
- hours
- fixed combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 230000009885 systemic effect Effects 0.000 claims abstract description 11
- 230000000694 effects Effects 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 230000005923 long-lasting effect Effects 0.000 claims description 2
- 230000007774 longterm Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 description 13
- 239000000730 antalgic agent Substances 0.000 description 13
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- -1 butoxicaine Chemical compound 0.000 description 10
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- 239000004480 active ingredient Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
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- 239000008298 dragée Substances 0.000 description 4
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- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
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- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
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- 150000005599 propionic acid derivatives Chemical class 0.000 description 2
- WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 description 1
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- XOZLRRYPUKAKMU-UHFFFAOYSA-N 1,5-dimethyl-2-phenyl-4-(propan-2-ylamino)-3-pyrazolone Chemical compound O=C1C(NC(C)C)=C(C)N(C)N1C1=CC=CC=C1 XOZLRRYPUKAKMU-UHFFFAOYSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- GNUXVOXXWGNPIV-UHFFFAOYSA-N 1-methyl-5-[[methyl(1-phenylpropan-2-yl)amino]methyl]-2-phenyl-4-propan-2-yl-3-pyrazolone Chemical compound CN1N(C=2C=CC=CC=2)C(=O)C(C(C)C)=C1CN(C)C(C)CC1=CC=CC=C1 GNUXVOXXWGNPIV-UHFFFAOYSA-N 0.000 description 1
- BFUUJUGQJUTPAF-UHFFFAOYSA-N 2-(3-amino-4-propoxybenzoyl)oxyethyl-diethylazanium;chloride Chemical compound [Cl-].CCCOC1=CC=C(C(=O)OCC[NH+](CC)CC)C=C1N BFUUJUGQJUTPAF-UHFFFAOYSA-N 0.000 description 1
- BMDZNGISRKXXIF-UHFFFAOYSA-N 2-(dimethylamino)ethyl 3-amino-4-chlorobenzoate Chemical compound CN(C)CCOC(=O)C1=CC=C(Cl)C(N)=C1 BMDZNGISRKXXIF-UHFFFAOYSA-N 0.000 description 1
- XLVXAUNDHWERBM-IVGWJTKZSA-N 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-n-[(2r,3r,4s,5r)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]acetamide Chemical compound CC1=C(CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 XLVXAUNDHWERBM-IVGWJTKZSA-N 0.000 description 1
- PUYOAVGNCWPANW-UHFFFAOYSA-N 2-methylpropyl 4-aminobenzoate Chemical compound CC(C)COC(=O)C1=CC=C(N)C=C1 PUYOAVGNCWPANW-UHFFFAOYSA-N 0.000 description 1
- PPCONEVACDVQBK-UHFFFAOYSA-N 2-pyrano[2,3-g]indol-2-ylacetic acid Chemical class O1C=CC=C2C3=NC(CC(=O)O)=CC3=CC=C21 PPCONEVACDVQBK-UHFFFAOYSA-N 0.000 description 1
- HEOZYYOUKGGSBJ-UHFFFAOYSA-N 5-(4-methoxybenzoyl)-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid Chemical compound C1=CC(OC)=CC=C1C(=O)C1=CC=C2N1CCC2C(O)=O HEOZYYOUKGGSBJ-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
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- QTGIAADRBBLJGA-UHFFFAOYSA-N Articaine Chemical compound CCCNC(C)C(=O)NC=1C(C)=CSC=1C(=O)OC QTGIAADRBBLJGA-UHFFFAOYSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
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- JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 description 1
- BRZANEXCSZCZCI-UHFFFAOYSA-N Nifenazone Chemical compound O=C1N(C=2C=CC=CC=2)N(C)C(C)=C1NC(=O)C1=CC=CN=C1 BRZANEXCSZCZCI-UHFFFAOYSA-N 0.000 description 1
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- TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 description 1
- FDMBBCOBEAVDAO-UHFFFAOYSA-N Stovaine Chemical compound CN(C)CC(C)(CC)OC(=O)C1=CC=CC=C1 FDMBBCOBEAVDAO-UHFFFAOYSA-N 0.000 description 1
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- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229940013798 meclofenamate Drugs 0.000 description 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 description 1
- 229960003464 mefenamic acid Drugs 0.000 description 1
- 229960001929 meloxicam Drugs 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229960002409 mepivacaine Drugs 0.000 description 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 1
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M metamizole sodium Chemical compound [Na+].O=C1C(N(CS([O-])(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 DJGAAPFSPWAYTJ-UHFFFAOYSA-M 0.000 description 1
- 229950005798 metiazinic acid Drugs 0.000 description 1
- LMINNBXUMGNKMM-UHFFFAOYSA-N metiazinic acid Chemical compound C1=C(CC(O)=O)C=C2N(C)C3=CC=CC=C3SC2=C1 LMINNBXUMGNKMM-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229960003251 morniflumate Drugs 0.000 description 1
- LDXSPUSKBDTEKA-UHFFFAOYSA-N morniflumate Chemical compound FC(F)(F)C1=CC=CC(NC=2C(=CC=CN=2)C(=O)OCCN2CCOCC2)=C1 LDXSPUSKBDTEKA-UHFFFAOYSA-N 0.000 description 1
- GCIGZRAXWDUHRE-UHFFFAOYSA-N n-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-n-methylpyridine-3-carboxamide Chemical compound CC=1N(C)N(C=2C=CC=CC=2)C(=O)C=1N(C)C(=O)C1=CC=CN=C1 GCIGZRAXWDUHRE-UHFFFAOYSA-N 0.000 description 1
- GDDYCOSWVJRUHM-UHFFFAOYSA-N n-(2,4-dichlorophenyl)-3-piperidin-1-ylbutanamide Chemical compound C1CCCCN1C(C)CC(=O)NC1=CC=C(Cl)C=C1Cl GDDYCOSWVJRUHM-UHFFFAOYSA-N 0.000 description 1
- UJCARUGFZOJPMI-UHFFFAOYSA-N n-(2-methoxy-4,6-dimethylphenyl)-3-(2-methylpiperidin-1-yl)propanamide Chemical compound COC1=CC(C)=CC(C)=C1NC(=O)CCN1C(C)CCCC1 UJCARUGFZOJPMI-UHFFFAOYSA-N 0.000 description 1
- NFZJQAPVHJPJMD-UHFFFAOYSA-N n-[4-(2,2,2-trichloro-1-hydroxyethoxy)phenyl]acetamide Chemical compound CC(=O)NC1=CC=C(OC(O)C(Cl)(Cl)Cl)C=C1 NFZJQAPVHJPJMD-UHFFFAOYSA-N 0.000 description 1
- JKNDAGNFBPJGEF-UHFFFAOYSA-N n-methyl-2-(6-oxo-3-phenylpyridazin-1-yl)-n-(1-phenylpropan-2-yl)acetamide Chemical compound N1=C(C=2C=CC=CC=2)C=CC(=O)N1CC(=O)N(C)C(C)CC1=CC=CC=C1 JKNDAGNFBPJGEF-UHFFFAOYSA-N 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229960002187 nifenazone Drugs 0.000 description 1
- 210000000929 nociceptor Anatomy 0.000 description 1
- 108091008700 nociceptors Proteins 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 229960000273 oxametacin Drugs 0.000 description 1
- AJRNYCDWNITGHF-UHFFFAOYSA-N oxametacin Chemical compound CC1=C(CC(=O)NO)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 AJRNYCDWNITGHF-UHFFFAOYSA-N 0.000 description 1
- 229960002739 oxaprozin Drugs 0.000 description 1
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
- 229960003502 oxybuprocaine Drugs 0.000 description 1
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 description 1
- 229940124641 pain reliever Drugs 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical class O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229960001896 pramocaine Drugs 0.000 description 1
- DQKXQSGTHWVTAD-UHFFFAOYSA-N pramocaine Chemical compound C1=CC(OCCCC)=CC=C1OCCCN1CCOCC1 DQKXQSGTHWVTAD-UHFFFAOYSA-N 0.000 description 1
- 229960003101 pranoprofen Drugs 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 229960003981 proparacaine Drugs 0.000 description 1
- 229950011219 propipocaine Drugs 0.000 description 1
- STHAHFPLLHRRRO-UHFFFAOYSA-N propipocaine Chemical compound C1=CC(OCCC)=CC=C1C(=O)CCN1CCCCC1 STHAHFPLLHRRRO-UHFFFAOYSA-N 0.000 description 1
- 229960002466 proquazone Drugs 0.000 description 1
- JTIGKVIOEQASGT-UHFFFAOYSA-N proquazone Chemical compound N=1C(=O)N(C(C)C)C2=CC(C)=CC=C2C=1C1=CC=CC=C1 JTIGKVIOEQASGT-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 1
- 229950000385 ramifenazone Drugs 0.000 description 1
- 229960001549 ropivacaine Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- JZWFDVDETGFGFC-UHFFFAOYSA-N salacetamide Chemical compound CC(=O)NC(=O)C1=CC=CC=C1O JZWFDVDETGFGFC-UHFFFAOYSA-N 0.000 description 1
- 229950009280 salacetamide Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical class OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 229960000953 salsalate Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229950002953 sulcaine Drugs 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 229940072040 tricaine Drugs 0.000 description 1
- FQZJYWMRQDKBQN-UHFFFAOYSA-N tricaine methanesulfonate Chemical compound CS([O-])(=O)=O.CCOC(=O)C1=CC=CC([NH3+])=C1 FQZJYWMRQDKBQN-UHFFFAOYSA-N 0.000 description 1
- GOZBHBFUQHMKQB-UHFFFAOYSA-N trimecaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C GOZBHBFUQHMKQB-UHFFFAOYSA-N 0.000 description 1
- 229950002569 trimecaine Drugs 0.000 description 1
- 229950005920 vadocaine Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19715594A DE19715594A1 (de) | 1997-04-15 | 1997-04-15 | Analgetika-Kombination |
| DE19715594 | 1997-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2210754T3 true ES2210754T3 (es) | 2004-07-01 |
Family
ID=7826504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98921419T Expired - Lifetime ES2210754T3 (es) | 1997-04-15 | 1998-04-02 | Combinacion de analgesicos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6929805B2 (OSRAM) |
| EP (1) | EP0979087B1 (OSRAM) |
| JP (1) | JP2002503221A (OSRAM) |
| KR (1) | KR100532647B1 (OSRAM) |
| CN (1) | CN1177589C (OSRAM) |
| AR (1) | AR012417A1 (OSRAM) |
| AT (1) | ATE253919T1 (OSRAM) |
| AU (1) | AU742622B2 (OSRAM) |
| BR (1) | BR9808875A (OSRAM) |
| CA (1) | CA2285979C (OSRAM) |
| DE (2) | DE19715594A1 (OSRAM) |
| DK (1) | DK0979087T3 (OSRAM) |
| ES (1) | ES2210754T3 (OSRAM) |
| HU (1) | HU225601B1 (OSRAM) |
| NO (1) | NO323022B1 (OSRAM) |
| NZ (1) | NZ500262A (OSRAM) |
| PL (1) | PL190863B1 (OSRAM) |
| PT (1) | PT979087E (OSRAM) |
| RS (1) | RS49620B (OSRAM) |
| RU (1) | RU2218180C2 (OSRAM) |
| TR (1) | TR199902396T2 (OSRAM) |
| WO (1) | WO1998046235A1 (OSRAM) |
| YU (1) | YU52999A (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423697B1 (en) * | 1999-01-14 | 2002-07-23 | Mark Friedman | Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache, facial pain, and cervical-muscle spasm |
| EP1231900A1 (en) * | 1999-11-23 | 2002-08-21 | The Robert Gordon University | Bilayered buccal tablets comprising nicotine |
| AU3162001A (en) * | 1999-12-21 | 2001-07-03 | Id-Pharma Gmbh | Medicament, a method for its production and the use thereof |
| KR20010069756A (ko) * | 2001-05-08 | 2001-07-25 | 유형선 | 소염진통제인 아세메타신을 함유하며 장관내 특히대장에서의 약물 방출 속도가 조절되는 약물 전달 체계에대한 약제학적 경구용 조성물 및 그에 대한 제조방법 |
| US20030035839A1 (en) * | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| US6863901B2 (en) | 2001-11-30 | 2005-03-08 | Collegium Pharmaceutical, Inc. | Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration |
| US6827946B2 (en) * | 2001-12-05 | 2004-12-07 | Collegium Pharmaceutical, Inc. | Compositions containing both sedative and non-sedative antihistamines |
| DE102004001093A1 (de) * | 2004-01-05 | 2005-07-28 | Liedtke, Rainer K., Dr. | Zusammensetzung und Methode einer synergistischen topischen Therapie neuromuskulärer Schmerzen |
| DE102004040630A1 (de) * | 2004-08-21 | 2006-03-09 | Balaban, Romulus, Dr.med. | Kombinationstherapie mit Procain |
| RU2283112C1 (ru) * | 2005-10-04 | 2006-09-10 | Открытое акционерное общество "Нижегородский химико-фармацевтический завод" | Противовоспалительное лекарственное средство |
| EP2120945A1 (en) * | 2007-02-28 | 2009-11-25 | Collegium Pharmaceutical, Inc. | Antihistamine combination |
| DE102008007212B3 (de) | 2008-02-01 | 2009-10-15 | BSH Bosch und Siemens Hausgeräte GmbH | Gehäuse für den Antrieb eines elektrischen Geräts, insbesondere eines Haushaltsgeräts |
| US8690839B2 (en) | 2008-08-01 | 2014-04-08 | Tian Xia | Devices for delivering a medicament and connector for same |
| US8231588B2 (en) * | 2008-08-01 | 2012-07-31 | Tian Xia | Methods for ameliorating pain and devices for delivering a medicament |
| US8905980B2 (en) | 2008-08-01 | 2014-12-09 | Tian Xia | Devices for delivering a medicament and methods for ameliorating pain |
| US20130049931A1 (en) * | 2011-08-25 | 2013-02-28 | Elwha LLC, a limited liability company of the State of Delaware | Systems, devices, methods, and admixtures of transponders and food products for indication of food attributes |
| US10016580B2 (en) | 2013-12-17 | 2018-07-10 | Biovision Technologies, Llc | Methods for treating sinus diseases |
| US9510743B2 (en) | 2013-12-17 | 2016-12-06 | Biovision Technologies, Llc | Stabilized surgical device for performing a sphenopalatine ganglion block procedure |
| US9516995B2 (en) | 2013-12-17 | 2016-12-13 | Biovision Technologies, Llc | Surgical device for performing a sphenopalatine ganglion block procedure |
| US9694163B2 (en) | 2013-12-17 | 2017-07-04 | Biovision Technologies, Llc | Surgical device for performing a sphenopalatine ganglion block procedure |
| DE102015114799A1 (de) * | 2015-09-04 | 2017-03-09 | Knorr-Bremse Systeme für Nutzfahrzeuge GmbH | Druckmittelaggregat, mit einem durch Spritzgießen hergestellten Gehäuse aus Kunststoff sowie Verfahren zu seiner Herstellung |
| WO2019064090A1 (en) * | 2017-09-28 | 2019-04-04 | Zenvision Pharma Llp | NOVEL PHARMACEUTICAL COMPOSITION COMPRISING MEFENAMIC ACID AND OTHER ANALGESICS |
| WO2020005910A1 (en) | 2018-06-28 | 2020-01-02 | Sandler Scientific, Llc | Sino-nasal rinse delivery device with agitation, flow-control and integrated medication management system |
| WO2025170507A1 (en) * | 2024-02-07 | 2025-08-14 | Oncozenge Ab | A lozenge |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1026501A (en) | 1961-10-13 | 1966-04-20 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
| US4446140A (en) * | 1981-12-10 | 1984-05-01 | Nelson Research & Development Company | Method and composition for treating mouth pain |
| DE3328401A1 (de) | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | Injizierbare loesung zur behandlung von entzuendungen |
| US4851233A (en) | 1986-10-06 | 1989-07-25 | Warner-Lambert Company | Sustained release formulations |
| US5064858A (en) * | 1988-08-17 | 1991-11-12 | Spectrum Pharmaceutical Corporation | Protected complex of procaine for the treatment of symptoms from narcotics addiction, tinnitus and Alzheimer's disease |
| ATE114472T1 (de) | 1989-09-21 | 1994-12-15 | American Cyanamid Co | System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe. |
| IE66933B1 (en) * | 1990-01-15 | 1996-02-07 | Elan Corp Plc | Controlled absorption naproxen formulation for once-daily administration |
| IT1242642B (it) | 1990-04-17 | 1994-05-16 | Alfa Wassermann Spa | Formulazioni iniettabili contenenti naproxen sale sodico. |
| GB9121204D0 (en) | 1991-10-04 | 1991-11-20 | Euro Celtique Sa | Medicament |
| ES2173096T3 (es) * | 1992-08-05 | 2002-10-16 | Faulding F H & Co Ltd | Composicion farmaceutica peletizada. |
| US5609884A (en) * | 1992-08-31 | 1997-03-11 | G. D. Searle & Co. | Controlled release naproxen sodium plus naproxen combination tablet |
| US5451409A (en) * | 1993-11-22 | 1995-09-19 | Rencher; William F. | Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends |
| US5702723A (en) * | 1994-08-02 | 1997-12-30 | Griffin; David | Multi-stage delivery system for ingestible medications or nutrients |
| TW483763B (en) | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
| US5547948A (en) | 1995-01-17 | 1996-08-20 | American Home Products Corporation | Controlled release of steroids from sugar coatings |
| JPH11502839A (ja) | 1995-03-29 | 1999-03-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | 鎮咳剤マイクロカプセル |
-
1997
- 1997-04-15 DE DE19715594A patent/DE19715594A1/de not_active Withdrawn
-
1998
- 1998-04-02 PL PL336154A patent/PL190863B1/pl unknown
- 1998-04-02 DE DE59810166T patent/DE59810166D1/de not_active Expired - Lifetime
- 1998-04-02 DK DK98921419T patent/DK0979087T3/da active
- 1998-04-02 WO PCT/EP1998/001926 patent/WO1998046235A1/de not_active Ceased
- 1998-04-02 ES ES98921419T patent/ES2210754T3/es not_active Expired - Lifetime
- 1998-04-02 AU AU74286/98A patent/AU742622B2/en not_active Ceased
- 1998-04-02 HU HU0003636A patent/HU225601B1/hu not_active IP Right Cessation
- 1998-04-02 RU RU99124179/15A patent/RU2218180C2/ru active
- 1998-04-02 NZ NZ500262A patent/NZ500262A/en not_active Application Discontinuation
- 1998-04-02 JP JP54342398A patent/JP2002503221A/ja not_active Ceased
- 1998-04-02 PT PT98921419T patent/PT979087E/pt unknown
- 1998-04-02 RS YUP-529/99A patent/RS49620B/sr unknown
- 1998-04-02 YU YU52999A patent/YU52999A/sh unknown
- 1998-04-02 TR TR1999/02396T patent/TR199902396T2/xx unknown
- 1998-04-02 KR KR10-1999-7009433A patent/KR100532647B1/ko not_active Expired - Fee Related
- 1998-04-02 AT AT98921419T patent/ATE253919T1/de not_active IP Right Cessation
- 1998-04-02 CN CNB988041928A patent/CN1177589C/zh not_active Expired - Fee Related
- 1998-04-02 EP EP98921419A patent/EP0979087B1/de not_active Expired - Lifetime
- 1998-04-02 US US09/402,737 patent/US6929805B2/en not_active Expired - Lifetime
- 1998-04-02 BR BR9808875-0A patent/BR9808875A/pt not_active Application Discontinuation
- 1998-04-02 CA CA002285979A patent/CA2285979C/en not_active Expired - Lifetime
- 1998-04-14 AR ARP980101703A patent/AR012417A1/es active IP Right Grant
-
1999
- 1999-09-24 NO NO19994663A patent/NO323022B1/no not_active IP Right Cessation
Also Published As
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