ES2196197T3 - Derivados de benzamida con propiedades inhibidoras de trombina. - Google Patents

Derivados de benzamida con propiedades inhibidoras de trombina.

Info

Publication number
ES2196197T3
ES2196197T3 ES96944604T ES96944604T ES2196197T3 ES 2196197 T3 ES2196197 T3 ES 2196197T3 ES 96944604 T ES96944604 T ES 96944604T ES 96944604 T ES96944604 T ES 96944604T ES 2196197 T3 ES2196197 T3 ES 2196197T3
Authority
ES
Spain
Prior art keywords
alkyl
halogen
alkoxy
optionally substituted
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96944604T
Other languages
English (en)
Inventor
Nigel Stephen Watson
Martin Pass
Vipulkumar Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2196197T3 publication Critical patent/ES2196197T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto representado por la fórmula (I)**fórmula** donde R1 y R2 representan independientemente un grupo o R1 y R2 forman juntos un grupo heterocicloalquilo o heterocicloalquenilo C3-7, que puede estar opcionalmente sustituido con alquilo C1-6, alcoxi C1-4, halógeno, ácido carboxílico o un grupo éster de ácido carboxílico C1-4; R3 representa hidrógeno, alquilo C1-3, halógeno, o alcoxi C1-2; R4, R5 y R6 representan independientemente hidrógeno, o halógeno; R7 representa hidrógeno o alquilo C1-6; R8 representa hidrógeno, cicloalquilo C3-7, cicloalquenilo C3-7, heterocicloalquilo C3-7, heterocicloalquenilo C3-7, fenilo, naftilo, un anillo heterocíclico aromático de 5 ó 6 miembros que contiene uno o más heteroátomos seleccionados de átomos de nitrógeno, azufre y oxígeno, o un sistema bicíclico de anillos condensados que contiene uno o más átomos de nitrógeno, azufre y oxígeno, grupos que opcionalmente están sustituidos con uno o más grupos seleccionados de halógeno, hidroxi, CN, alquilo C1-6, alcoxi C1-6, aciloxi C1-6, NR9R10, NHCOR11, NHSO2R12, COR13, CO2R14, CONR15R16, y SO2NHR17.
ES96944604T 1995-12-15 1996-12-13 Derivados de benzamida con propiedades inhibidoras de trombina. Expired - Lifetime ES2196197T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9525620.2A GB9525620D0 (en) 1995-12-15 1995-12-15 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2196197T3 true ES2196197T3 (es) 2003-12-16

Family

ID=10785445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96944604T Expired - Lifetime ES2196197T3 (es) 1995-12-15 1996-12-13 Derivados de benzamida con propiedades inhibidoras de trombina.

Country Status (8)

Country Link
US (1) US6326386B1 (es)
EP (1) EP1021411B1 (es)
AT (1) ATE233733T1 (es)
AU (1) AU1303097A (es)
DE (1) DE69626554T2 (es)
ES (1) ES2196197T3 (es)
GB (1) GB9525620D0 (es)
WO (1) WO1997022589A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9821483D0 (en) * 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
US6344486B1 (en) 1998-04-03 2002-02-05 3-Dimensional Pharmaceuticals, Inc. Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors
AR023819A1 (es) * 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
EP1211239A4 (en) * 1999-09-06 2003-08-06 Takeda Chemical Industries Ltd METHOD FOR PRODUCING 2,3-DIHYDROAZEPINE DERIVATIVES
WO2002012207A1 (en) 2000-08-04 2002-02-14 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
GB0117144D0 (en) * 2001-07-13 2001-09-05 Glaxo Group Ltd Process
WO2005013888A2 (en) * 2003-05-14 2005-02-17 Cytokinetics, Inc. Compounds, compositions and methods
US8697387B2 (en) * 2006-06-02 2014-04-15 DiscoverRx Corporation Methods for identifying agents and their use for the prevention of restenosis
US9267134B2 (en) 2011-05-09 2016-02-23 The University Court Of The University Of Glasgow Methods of modulating MicroRNAs in the treatment of pulmonary arterial hypertension
EP4295841A3 (en) * 2014-06-06 2024-03-13 The Scripps Research Institute Sulfur (vi) fluoride compounds and their use in click-reaction
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW257757B (es) * 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
EP0825184B1 (en) * 1993-03-29 2001-06-20 AstraZeneca AB Heterocyclic derivatives as platelet aggregation inhibitors

Also Published As

Publication number Publication date
GB9525620D0 (en) 1996-02-14
DE69626554T2 (de) 2004-02-12
AU1303097A (en) 1997-07-14
US6326386B1 (en) 2001-12-04
DE69626554D1 (de) 2003-04-10
WO1997022589A1 (en) 1997-06-26
ATE233733T1 (de) 2003-03-15
EP1021411A1 (en) 2000-07-26
EP1021411B1 (en) 2003-03-05

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