DE69626554D1 - Benzamid derivate als thrombin-inhibitoren - Google Patents
Benzamid derivate als thrombin-inhibitorenInfo
- Publication number
- DE69626554D1 DE69626554D1 DE69626554T DE69626554T DE69626554D1 DE 69626554 D1 DE69626554 D1 DE 69626554D1 DE 69626554 T DE69626554 T DE 69626554T DE 69626554 T DE69626554 T DE 69626554T DE 69626554 D1 DE69626554 D1 DE 69626554D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- halogen
- alkoxy
- optionally substituted
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9525620 | 1995-12-15 | ||
| GBGB9525620.2A GB9525620D0 (en) | 1995-12-15 | 1995-12-15 | Chemical compounds |
| PCT/EP1996/005743 WO1997022589A1 (en) | 1995-12-15 | 1996-12-13 | Benzamide derivatives as thrombin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69626554D1 true DE69626554D1 (de) | 2003-04-10 |
| DE69626554T2 DE69626554T2 (de) | 2004-02-12 |
Family
ID=10785445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69626554T Expired - Fee Related DE69626554T2 (de) | 1995-12-15 | 1996-12-13 | Benzamid derivate als thrombin-inhibitoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6326386B1 (de) |
| EP (1) | EP1021411B1 (de) |
| AT (1) | ATE233733T1 (de) |
| AU (1) | AU1303097A (de) |
| DE (1) | DE69626554T2 (de) |
| ES (1) | ES2196197T3 (de) |
| GB (1) | GB9525620D0 (de) |
| WO (1) | WO1997022589A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9821483D0 (en) * | 1998-10-03 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| US6344486B1 (en) | 1998-04-03 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Benzamide and sulfonamide substituted aminoguanidines and alkoxyguanidines as protease inhibitors |
| AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
| EP1211239A4 (de) * | 1999-09-06 | 2003-08-06 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von 2,3-dihydroazepin-derivaten |
| EP1307432A1 (de) | 2000-08-04 | 2003-05-07 | 3-Dimensional Pharmaceuticals, Inc. | Zyklische oxyguanidin-proteasinhibitoren |
| GB0117144D0 (en) * | 2001-07-13 | 2001-09-05 | Glaxo Group Ltd | Process |
| WO2005013888A2 (en) * | 2003-05-14 | 2005-02-17 | Cytokinetics, Inc. | Compounds, compositions and methods |
| WO2007143211A2 (en) * | 2006-06-02 | 2007-12-13 | Bioseek, Inc. | Methods for identifying agents and their use for the prevention of restenosis |
| BR112013029016A2 (pt) | 2011-05-09 | 2017-01-17 | Cambridge Entpr Ltd | métodos de modulação de micrornas no tratamento da hipertensão arterial pulmonar |
| EP3892610B1 (de) * | 2014-06-06 | 2023-08-16 | The Scripps Research Institute | Schwefel(vi)fluoridverbindungen und deren verwendung in click-reaktionen |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW257757B (de) * | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| SK120895A3 (en) * | 1993-03-29 | 1996-06-05 | Zeneca Ltd | Pyridine derivatives, process for preparing the same and intermediate products in this process and pharmaceutical compositions containing them |
-
1995
- 1995-12-15 GB GBGB9525620.2A patent/GB9525620D0/en active Pending
-
1996
- 1996-12-13 AU AU13030/97A patent/AU1303097A/en not_active Abandoned
- 1996-12-13 ES ES96944604T patent/ES2196197T3/es not_active Expired - Lifetime
- 1996-12-13 EP EP96944604A patent/EP1021411B1/de not_active Expired - Lifetime
- 1996-12-13 WO PCT/EP1996/005743 patent/WO1997022589A1/en active IP Right Grant
- 1996-12-13 DE DE69626554T patent/DE69626554T2/de not_active Expired - Fee Related
- 1996-12-13 AT AT96944604T patent/ATE233733T1/de not_active IP Right Cessation
-
2000
- 2000-10-04 US US09/678,610 patent/US6326386B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6326386B1 (en) | 2001-12-04 |
| AU1303097A (en) | 1997-07-14 |
| EP1021411A1 (de) | 2000-07-26 |
| WO1997022589A1 (en) | 1997-06-26 |
| ES2196197T3 (es) | 2003-12-16 |
| EP1021411B1 (de) | 2003-03-05 |
| GB9525620D0 (en) | 1996-02-14 |
| ATE233733T1 (de) | 2003-03-15 |
| DE69626554T2 (de) | 2004-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |