ES2192205T3 - Uso de un compuesto que aumenta la actividad o la cantidad de hemooxigenasa (ho) en un mamifero. - Google Patents
Uso de un compuesto que aumenta la actividad o la cantidad de hemooxigenasa (ho) en un mamifero.Info
- Publication number
- ES2192205T3 ES2192205T3 ES95932094T ES95932094T ES2192205T3 ES 2192205 T3 ES2192205 T3 ES 2192205T3 ES 95932094 T ES95932094 T ES 95932094T ES 95932094 T ES95932094 T ES 95932094T ES 2192205 T3 ES2192205 T3 ES 2192205T3
- Authority
- ES
- Spain
- Prior art keywords
- activity
- control
- inflammation
- hemooxigenasa
- mammer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 102000016761 Haem oxygenases Human genes 0.000 abstract 5
- 108050006318 Haem oxygenases Proteins 0.000 abstract 5
- 206010061218 Inflammation Diseases 0.000 abstract 4
- 230000004054 inflammatory process Effects 0.000 abstract 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Rear-View Mirror Devices That Are Mounted On The Exterior Of The Vehicle (AREA)
- Mirrors, Picture Frames, Photograph Stands, And Related Fastening Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE CONSIGUE CONTROLAR LA INFLAMACION MEDIANTE EL CONTROL DEL NIVEL Y/O ACTIVIDAD DE LA ENZIMA HEMO-OXIGENASA (HO). EL INDUCTOR HO ES ANTIINFLAMATORIO (DIBUJO 14) Y SE UTILIZA PARA TRATAR INFLAMACIONES COMO PUEDEN SER LAS ENFERMEDADES INFLAMATORIAS CRONICAS. EL INHIBIDOR HO FAVORECE LA INFLAMACION Y SE UTILIZA PARA TRATAR AFECCIONES DE INMUNOSUPRESION. DE FORMA ALTERNATIVA, O ADICIONAL, SE CONSIGUE EL CONTROL DE LA ACTIVIDAD DE LA HEMOOXIGENASA MEDIANTE EL CONTROL DE LOS NIVELES DE OXIDO NITRICO, YA QUE LOS NIVELES ELEVADOS FAVORECEN LA INFLAMACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002132690A CA2132690A1 (en) | 1994-09-22 | 1994-09-22 | Control and modulation of inflammatory response in humans in need of such control and modulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2192205T3 true ES2192205T3 (es) | 2003-10-01 |
Family
ID=4154382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95932094T Expired - Lifetime ES2192205T3 (es) | 1994-09-22 | 1995-09-22 | Uso de un compuesto que aumenta la actividad o la cantidad de hemooxigenasa (ho) en un mamifero. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0782441B1 (es) |
JP (1) | JPH10506388A (es) |
CN (1) | CN1213742C (es) |
AT (1) | ATE233551T1 (es) |
AU (1) | AU3528195A (es) |
CA (1) | CA2132690A1 (es) |
DE (1) | DE69529831T2 (es) |
DK (1) | DK0782441T3 (es) |
ES (1) | ES2192205T3 (es) |
NZ (1) | NZ292963A (es) |
PT (1) | PT782441E (es) |
WO (1) | WO1996009038A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5756492A (en) * | 1996-09-09 | 1998-05-26 | Sangstat Medical Corporation | Graft survival prolongation with porphyrins |
CA2309154C (en) | 1997-11-03 | 2010-02-16 | Duke University | Substituted porphyrins |
ES2257858T3 (es) | 1998-04-24 | 2006-08-01 | Duke University | Porfirinas sustituidas. |
JP2003500335A (ja) | 1998-12-17 | 2003-01-07 | サングスタット メディカル コーポレイション | ヘムオキシゲナーゼ活性の調節による移植片の生存を強化する方法 |
EP1616869B1 (en) | 1999-01-25 | 2012-04-04 | National Jewish Health | Substituted porphyrins and their therapeutic use |
EP1439842A4 (en) | 2001-06-01 | 2009-09-02 | Nat Jewish Med & Res Center | OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE |
CN1646140A (zh) | 2002-02-04 | 2005-07-27 | 阿尔法玛药品研发有限公司 | 可释放co的化合物在用于治疗炎症药物的制备中的应用 |
JP2005522521A (ja) * | 2002-04-15 | 2005-07-28 | ベス イスラエル デアコネス メディカル センター | ヘムオキシゲナーゼ−1およびヘム分解産物の使用法 |
US7485721B2 (en) | 2002-06-07 | 2009-02-03 | Duke University | Substituted porphyrins |
FR2842738B1 (fr) * | 2002-07-23 | 2006-02-10 | Negma Lerads | Utilisation d'une rheine pour la preparation d'un medicament pour le traitement de l'inflammation chronique, la prevention et le traitement du rejet des transplantations d'organes et de tissus |
EP1940425A4 (en) * | 2005-09-30 | 2010-02-03 | Ovation Pharmaceuticals Inc | METHOD FOR THE TREATMENT OF PANCREATITIS |
US11382895B2 (en) | 2008-05-23 | 2022-07-12 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
AU2011218316B2 (en) * | 2010-02-18 | 2015-08-20 | Vtv Therapeutics Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
WO2012145520A2 (en) | 2011-04-19 | 2012-10-26 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
JP6134710B2 (ja) | 2011-07-21 | 2017-05-24 | アルファーマ インコーポレイテッドAlfama,Inc. | 一酸化ルテニウム放出分子およびその使用 |
CN105727379A (zh) * | 2016-02-25 | 2016-07-06 | 顾宇春 | 血红素加氧酶药物洗脱支架 |
CN110585215B (zh) * | 2019-09-19 | 2023-06-02 | 中山大学 | 氯化血红素及其复合物在医药中的新应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5010073A (en) * | 1989-10-05 | 1991-04-23 | The Rockefeller University | Use of liposomes as carriers for metalloporphyrins |
US5102670A (en) * | 1990-09-14 | 1992-04-07 | Abraham Nader G | Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels |
DE69229598T2 (de) * | 1991-04-19 | 1999-11-04 | Childrens Medical Center | Verfahren zur vorbeugung nmda-rezeptorkomplex-vermittelter neuronaler schäden |
CA2119572C (en) * | 1991-09-24 | 2005-07-05 | Larry Kay Keefer | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs |
GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
WO1994013252A1 (en) * | 1992-12-10 | 1994-06-23 | Hemogen, Inc. | Method for stimulating production of heme oxygenase using vitamin b12 |
-
1994
- 1994-09-22 CA CA002132690A patent/CA2132690A1/en not_active Abandoned
-
1995
- 1995-09-22 ES ES95932094T patent/ES2192205T3/es not_active Expired - Lifetime
- 1995-09-22 CN CNB95196383XA patent/CN1213742C/zh not_active Expired - Fee Related
- 1995-09-22 EP EP95932094A patent/EP0782441B1/en not_active Revoked
- 1995-09-22 JP JP8510696A patent/JPH10506388A/ja not_active Ceased
- 1995-09-22 AT AT95932094T patent/ATE233551T1/de not_active IP Right Cessation
- 1995-09-22 AU AU35281/95A patent/AU3528195A/en not_active Abandoned
- 1995-09-22 WO PCT/GB1995/002249 patent/WO1996009038A2/en not_active Application Discontinuation
- 1995-09-22 NZ NZ292963A patent/NZ292963A/en unknown
- 1995-09-22 DE DE69529831T patent/DE69529831T2/de not_active Revoked
- 1995-09-22 DK DK95932094T patent/DK0782441T3/da active
- 1995-09-22 PT PT95932094T patent/PT782441E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
AU3528195A (en) | 1996-04-09 |
WO1996009038A2 (en) | 1996-03-28 |
CN1213742C (zh) | 2005-08-10 |
NZ292963A (en) | 2001-06-29 |
DK0782441T3 (da) | 2003-06-30 |
CA2132690A1 (en) | 1996-03-23 |
ATE233551T1 (de) | 2003-03-15 |
EP0782441A1 (en) | 1997-07-09 |
CN1166785A (zh) | 1997-12-03 |
DE69529831D1 (de) | 2003-04-10 |
EP0782441B1 (en) | 2003-03-05 |
PT782441E (pt) | 2003-07-31 |
DE69529831T2 (de) | 2003-12-24 |
JPH10506388A (ja) | 1998-06-23 |
WO1996009038A3 (en) | 1996-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2192205T3 (es) | Uso de un compuesto que aumenta la actividad o la cantidad de hemooxigenasa (ho) en un mamifero. | |
ATE135231T1 (de) | Verwendung von ''cartilage-inducing factor'' (cif) zur behandlung von hemato- oder lymphopoietischen krankheiten | |
CA2105529A1 (en) | Composition comprising non-steroidal anti-inflammatory agent and effectively non-antibacterial tetracycline | |
CA2031368A1 (en) | Composition comprising non-steroidal non-inflammatory agent and effectively non-antibacterial tetracycline | |
DE19975031I2 (de) | Verwendung von 4-Aminosalicyls{ure als entz}ndungshemmender Wirkstoff. | |
NL930005I2 (nl) | 17 Beta-gesubstitueerde-4-aza-5alfa-androstenonen en gebruik ervan als inhibitoren van 5alfa-reduct ase. | |
DE69738693D1 (de) | On wunden- und brandheilung | |
IT8519382A0 (it) | Composizioni analgesiche e antiinfiammatorie comprendenti difeni dramina e metodi di usare le stesse | |
IT8123988A0 (it) | Impiego della combinazione di un inibitore della aromatasi con un antiandrogeno per la profilassi ela terapia dell'iperplasia della prostata. | |
ES2187560T3 (es) | Dentifrico antiseptico. | |
ES2160892T3 (es) | Uso de una mezcla de tensioactivos para inhibir la corrosion. | |
ES2138940T1 (es) | Quelactantes de plata del acido etilendiamintriacetico y del acido n-acil etilendiamintriacetico. | |
EP0751954A4 (en) | ANTI-INFLAMMATION COMPOSITION AND METHOD IN WHICH DES-TYR DYNORPHINE AND ANALOGUE ARE USED | |
ATE195528T1 (de) | Steroidnitritesterderivate und ihre verwendung als entzündungshemmende medikamente | |
SV1994000076A (es) | Derivados de acido n-acetil neuraminico cristalino y su preparacion ref. 1123a/sv | |
ES2094267T3 (es) | Utilizacion de micelio de hongos como agente auxiliar para suelos. | |
ES2086471T3 (es) | Medio para la proteccion temporal contra el oscurecimiento de superficies de plata y superficies de cobre desnudas y procedimiento para su utilizacion. | |
MY106885A (en) | Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides | |
ATE206052T1 (de) | Verwendung von sphingosin-1-phosphat, sphingosin- 1-phosphat-derivaten und/oder deren gemische zur behandlung von entzündlichen hautkrankheiten | |
EE9700350A (et) | COMT-inhibiitorite uus kasutamine ja diabeetiliste vaskulaarsete häirete ärahoidmise meetod | |
ES2161293T3 (es) | Derivados de enol acilados como profarmacos de inhibidores de la elastasa. | |
WO1998047494A3 (en) | Novel use of matrix metalloproteinase inhibitors | |
DK0673646T3 (da) | Anvendelse af deoxyspergualin til fremstilling af et lægemiddel til behandling af inflammatorisk-hyperreaktive sygdomme | |
DK1017377T3 (da) | Anvendelse af 6,7-substituerede 2-aminotetraliner til behandling af af cytokin fremkaldte inflammatoriske tilstande | |
ITMI911439A1 (it) | Composizione farmaceutica ad uso topico per il trattamento di cicatrizzazione e riepitelizzazione di ulcere flebostatiche croniche |