ES2189206T3 - Beta-alcoxiacrilatos contra la malaria. - Google Patents

Beta-alcoxiacrilatos contra la malaria.

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Publication number
ES2189206T3
ES2189206T3 ES98935020T ES98935020T ES2189206T3 ES 2189206 T3 ES2189206 T3 ES 2189206T3 ES 98935020 T ES98935020 T ES 98935020T ES 98935020 T ES98935020 T ES 98935020T ES 2189206 T3 ES2189206 T3 ES 2189206T3
Authority
ES
Spain
Prior art keywords
alcoxiacrylates
beta
against malaria
malaria
chloroquine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98935020T
Other languages
English (en)
Inventor
Jawad Alzeer
Jacques Chollet
Christian Hubschwerlen
Hugues Matile
Robert George Ridley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
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Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2189206T3 publication Critical patent/ES2189206T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)

Abstract

La invención se refiere al uso de {be}-alcoxiacrilatos de fórmulas (IA) o (IB) en las que R, R{sup,1}, R{sup,6}, R{sup,7}, R{sup,8}, X y Z son como aquí se describen, como sustancias terapéuticamente activas, especialmente en el tratamiento o profilaxis de la malaria y a medicamentos que contienen estas sustancias.
ES98935020T 1997-07-09 1998-07-06 Beta-alcoxiacrilatos contra la malaria. Expired - Lifetime ES2189206T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97111607 1997-07-09

Publications (1)

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ES2189206T3 true ES2189206T3 (es) 2003-07-01

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ID=8227034

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ES98935020T Expired - Lifetime ES2189206T3 (es) 1997-07-09 1998-07-06 Beta-alcoxiacrilatos contra la malaria.

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US (1) US6084120A (es)
EP (1) EP0996439B1 (es)
JP (1) JP2002511881A (es)
KR (1) KR20010014339A (es)
CN (1) CN1109544C (es)
AT (1) ATE230718T1 (es)
AU (1) AU748990B2 (es)
BR (1) BR9810556A (es)
CA (1) CA2294931A1 (es)
DE (1) DE69810629T2 (es)
DK (1) DK0996439T3 (es)
ES (1) ES2189206T3 (es)
PT (1) PT996439E (es)
TR (1) TR200000005T2 (es)
WO (1) WO1999002150A1 (es)

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Publication number Priority date Publication date Assignee Title
AU2001268051A1 (en) * 2000-06-28 2002-01-08 Eli Lilly And Company Spla2 inhibitors
CN100443463C (zh) * 2005-06-28 2008-12-17 沈阳化工研究院 取代的对三氟甲基苯醚类化合物及其制备与应用
WO2007113170A1 (de) * 2006-03-29 2007-10-11 Basf Se Verwendung von strobilurinen zur behandlung von störungen des eisen-stoffwechsels
KR101280222B1 (ko) * 2010-04-21 2013-07-05 주식회사 오스코텍 알파-아릴메톡시아크릴레이트 유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN105431150B (zh) 2013-08-27 2017-09-29 中国中化股份有限公司 含取代苄氧基的醚类化合物作为制备抗肿瘤药物的应用
CN103601716A (zh) * 2013-11-20 2014-02-26 厦门大学 一种苯并噻吩取代肟醚类化合物及其制备方法与应用
CN103980179A (zh) * 2014-05-29 2014-08-13 厦门大学 一种吲哚取代肟醚类化合物及其制备方法与应用
US10519098B2 (en) * 2014-10-21 2019-12-31 Council Of Scientific & Industrial Research Aromatic derivatives as anti-malarial
US11882828B2 (en) 2015-06-02 2024-01-30 Syngenta Participations Ag Mosquito vector control compositions, methods and products utilizing same

Family Cites Families (17)

* Cited by examiner, † Cited by third party
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NZ213630A (en) * 1984-10-19 1990-02-26 Ici Plc Acrylic acid derivatives and fungicidal compositions
DE3519280A1 (de) * 1985-05-30 1986-12-04 Basf Ag, 6700 Ludwigshafen Stilbenderivate und fungizide, die diese verbindungen enthalten
GB8617648D0 (en) * 1986-07-18 1986-08-28 Ici Plc Fungicides
ES2053258T3 (es) * 1987-02-09 1994-07-16 Zeneca Ltd Fungicidas.
IL87020A (en) * 1987-07-11 1996-09-12 Schering Agrochemicals Ltd History of acrylic acid and their use as pesticides
ATE169616T1 (de) * 1988-11-21 1998-08-15 Zeneca Ltd Zwischenverbindungen zur herstellung von fungiziden
DE58908972D1 (de) * 1988-12-29 1995-03-16 Ciba Geigy Ag Aldimino- oder ketimino-oxy-ortho-tolylacrylsäure-methylester, ihre herstellung und diese enthaltende fungizide.
DE3901607A1 (de) * 1989-01-20 1990-08-16 Basf Ag Schwefelhaltige acrylsaeureester und diese enthaltende fungizide
EP0433233B1 (de) * 1989-12-14 1995-01-25 Ciba-Geigy Ag Heterocyclische Verbindungen
PH11991042549B1 (es) * 1990-06-05 2000-12-04
ES2110421T5 (es) * 1990-06-27 2004-12-01 Basf Aktiengesellschaft O-bencil-oximeteres y los agentes protectores de las plantas que contienen estos compuestos.
DE4028391A1 (de) * 1990-09-07 1992-03-12 Basf Ag (alpha)-arylacrylsaeurederivate, ihre herstellung und verwendung zur bekaempfung von schaedlingen und pilzen
DE4029192A1 (de) * 1990-09-14 1992-03-19 Basf Ag Verwendung von (alpha)-arylacrylsaeurederivaten zur bekaempfung von schaedlingen
FR2670781B1 (fr) * 1990-12-21 1994-09-16 Roussel Uclaf Nouveaux derives de l'acide alpha-methylene 6-styryl phenyl acrylique, leur procede de preparation et leur application comme pesticides.
FR2670782A1 (fr) * 1990-12-24 1992-06-26 Valoris Chimie Fine Lab Ethers couronnes acridiniques et ethers couronnes acridinoniques.
DE4117371A1 (de) * 1991-05-28 1992-12-03 Basf Ag Antimykotische mittel, die phenylessigsaeurederivate enthalten
TW224042B (es) * 1992-04-04 1994-05-21 Basf Ag

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Publication number Publication date
CA2294931A1 (en) 1999-01-21
EP0996439A1 (en) 2000-05-03
EP0996439B1 (en) 2003-01-08
DE69810629T2 (de) 2003-10-16
DK0996439T3 (da) 2003-05-05
ATE230718T1 (de) 2003-01-15
CN1262620A (zh) 2000-08-09
CN1109544C (zh) 2003-05-28
PT996439E (pt) 2003-04-30
AU8441198A (en) 1999-02-08
BR9810556A (pt) 2000-08-15
KR20010014339A (ko) 2001-02-26
US6084120A (en) 2000-07-04
JP2002511881A (ja) 2002-04-16
AU748990B2 (en) 2002-06-13
TR200000005T2 (tr) 2000-09-21
WO1999002150A1 (en) 1999-01-21
DE69810629D1 (de) 2003-02-13

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