ES2189206T3 - Beta-alcoxiacrilatos contra la malaria. - Google Patents

Beta-alcoxiacrilatos contra la malaria.

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Publication number
ES2189206T3
ES2189206T3 ES98935020T ES98935020T ES2189206T3 ES 2189206 T3 ES2189206 T3 ES 2189206T3 ES 98935020 T ES98935020 T ES 98935020T ES 98935020 T ES98935020 T ES 98935020T ES 2189206 T3 ES2189206 T3 ES 2189206T3
Authority
ES
Spain
Prior art keywords
alcoxiacrylates
beta
against malaria
sup
malaria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98935020T
Other languages
English (en)
Inventor
Jawad Alzeer
Jacques Chollet
Christian Hubschwerlen
Hugues Matile
Robert George Ridley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2189206T3 publication Critical patent/ES2189206T3/es
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Expired - Lifetime legal-status Critical Current

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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)

Abstract

La invención se refiere al uso de {be}-alcoxiacrilatos de fórmulas (IA) o (IB) en las que R, R{sup,1}, R{sup,6}, R{sup,7}, R{sup,8}, X y Z son como aquí se describen, como sustancias terapéuticamente activas, especialmente en el tratamiento o profilaxis de la malaria y a medicamentos que contienen estas sustancias.
ES98935020T 1997-07-09 1998-07-06 Beta-alcoxiacrilatos contra la malaria. Expired - Lifetime ES2189206T3 (es)

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EP97111607 1997-07-09

Publications (1)

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ES2189206T3 true ES2189206T3 (es) 2003-07-01

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ES98935020T Expired - Lifetime ES2189206T3 (es) 1997-07-09 1998-07-06 Beta-alcoxiacrilatos contra la malaria.

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US (1) US6084120A (es)
EP (1) EP0996439B1 (es)
JP (1) JP2002511881A (es)
KR (1) KR20010014339A (es)
CN (1) CN1109544C (es)
AT (1) ATE230718T1 (es)
AU (1) AU748990B2 (es)
BR (1) BR9810556A (es)
CA (1) CA2294931A1 (es)
DE (1) DE69810629T2 (es)
DK (1) DK0996439T3 (es)
ES (1) ES2189206T3 (es)
PT (1) PT996439E (es)
TR (1) TR200000005T2 (es)
WO (1) WO1999002150A1 (es)

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WO2002000641A2 (en) * 2000-06-28 2002-01-03 Eli Lilly And Company Spla2 inhibitors
CN100443463C (zh) * 2005-06-28 2008-12-17 沈阳化工研究院 取代的对三氟甲基苯醚类化合物及其制备与应用
US20100234366A1 (en) * 2006-03-29 2010-09-16 Bsf Se Use of Strobilurins for the Treatment of Disorders of Iron Metabolism
US8772290B2 (en) 2010-04-21 2014-07-08 Oscotech Inc. Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same
AU2014314799B2 (en) 2013-08-27 2017-05-25 Shenyang Research Institute Of Chemical Industry Co., Ltd. Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs
CN103601716A (zh) * 2013-11-20 2014-02-26 厦门大学 一种苯并噻吩取代肟醚类化合物及其制备方法与应用
CN103980179A (zh) * 2014-05-29 2014-08-13 厦门大学 一种吲哚取代肟醚类化合物及其制备方法与应用
EP3209639B1 (en) * 2014-10-21 2020-09-16 Council of Scientific and Industrial Research Compounds as anti-malarials and their process of preparation
BR112017025824B1 (pt) * 2015-06-02 2022-10-18 Syngenta Participations Ag Uso não terapêutico de compostos de metoxiacrilato, meios integrados de controle de vetores de mosquitos, material polimérico incorporado com o referido composto, métodos para controle de mosquitos, kit e método para tratar uma fibra, fio, rede e trama revestindo-os com propriedades inseticidas, método de preparação de um material polimérico, rede incorporada com um composto e composto de metoxiacrilato

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NZ213630A (en) * 1984-10-19 1990-02-26 Ici Plc Acrylic acid derivatives and fungicidal compositions
DE3519280A1 (de) * 1985-05-30 1986-12-04 Basf Ag, 6700 Ludwigshafen Stilbenderivate und fungizide, die diese verbindungen enthalten
GB8617648D0 (en) * 1986-07-18 1986-08-28 Ici Plc Fungicides
DE3889345T2 (de) * 1987-02-09 1994-09-01 Zeneca Ltd Schimmelbekämpfungsmittel.
YU47288B (sh) * 1987-07-11 1995-01-31 Schering Agrochemicals Limited Akrilatni fungicidi i postupak za njihovo dobijanje
DE68928783T2 (de) * 1988-11-21 1998-12-24 Zeneca Ltd., London Zwischenverbindungen zur Herstellung von Fungiziden
AU4639089A (en) * 1988-12-29 1990-08-01 Ciba-Geigy Ag Methyl esters of aldimino- or ketimino-oxy-ortho-tolylacrylic acid, manufacturing process and fungicides containing them
DE3901607A1 (de) * 1989-01-20 1990-08-16 Basf Ag Schwefelhaltige acrylsaeureester und diese enthaltende fungizide
DE59008356D1 (de) * 1989-12-14 1995-03-09 Ciba Geigy Ag Heterocyclische Verbindungen.
PH11991042549B1 (es) * 1990-06-05 2000-12-04
ATE161007T1 (de) * 1990-06-27 1997-12-15 Basf Ag O-benzyl-oximether und diese verbindungen enthaltende pflanzenschutzmittel
DE4028391A1 (de) * 1990-09-07 1992-03-12 Basf Ag (alpha)-arylacrylsaeurederivate, ihre herstellung und verwendung zur bekaempfung von schaedlingen und pilzen
DE4029192A1 (de) * 1990-09-14 1992-03-19 Basf Ag Verwendung von (alpha)-arylacrylsaeurederivaten zur bekaempfung von schaedlingen
FR2670781B1 (fr) * 1990-12-21 1994-09-16 Roussel Uclaf Nouveaux derives de l'acide alpha-methylene 6-styryl phenyl acrylique, leur procede de preparation et leur application comme pesticides.
FR2670782A1 (fr) * 1990-12-24 1992-06-26 Valoris Chimie Fine Lab Ethers couronnes acridiniques et ethers couronnes acridinoniques.
DE4117371A1 (de) * 1991-05-28 1992-12-03 Basf Ag Antimykotische mittel, die phenylessigsaeurederivate enthalten
TW224042B (es) * 1992-04-04 1994-05-21 Basf Ag

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EP0996439B1 (en) 2003-01-08
EP0996439A1 (en) 2000-05-03
ATE230718T1 (de) 2003-01-15
TR200000005T2 (tr) 2000-09-21
DK0996439T3 (da) 2003-05-05
JP2002511881A (ja) 2002-04-16
AU8441198A (en) 1999-02-08
KR20010014339A (ko) 2001-02-26
US6084120A (en) 2000-07-04
CN1109544C (zh) 2003-05-28
BR9810556A (pt) 2000-08-15
AU748990B2 (en) 2002-06-13
PT996439E (pt) 2003-04-30
CN1262620A (zh) 2000-08-09
DE69810629D1 (de) 2003-02-13
CA2294931A1 (en) 1999-01-21
DE69810629T2 (de) 2003-10-16
WO1999002150A1 (en) 1999-01-21

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