ES2187300B1 - Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. - Google Patents

Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2187300B1
ES2187300B1 ES200102517A ES200102517A ES2187300B1 ES 2187300 B1 ES2187300 B1 ES 2187300B1 ES 200102517 A ES200102517 A ES 200102517A ES 200102517 A ES200102517 A ES 200102517A ES 2187300 B1 ES2187300 B1 ES 2187300B1
Authority
ES
Spain
Prior art keywords
preparation
application
medicines
derivatives
sulfonamids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200102517A
Other languages
English (en)
Spanish (es)
Other versions
ES2187300A1 (es
Inventor
Ramon Merce-Vidal
Blas Andaluz-Mataro
Jordi Frigola-Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to ES200102517A priority Critical patent/ES2187300B1/es
Priority to UA20040604587A priority patent/UA78252C2/uk
Priority to BR0214243-0A priority patent/BR0214243A/pt
Priority to MXPA04004601A priority patent/MXPA04004601A/es
Priority to HR20040429A priority patent/HRP20040429B1/xx
Priority to YU41104A priority patent/RS41104A/sr
Priority to NZ543393A priority patent/NZ543393A/en
Priority to ES05021228T priority patent/ES2322068T3/es
Priority to PL02373894A priority patent/PL373894A1/xx
Priority to JP2003544012A priority patent/JP4416505B2/ja
Priority to AT05021228T priority patent/ATE428694T1/de
Priority to CNB028240804A priority patent/CN1271052C/zh
Priority to IL16188502A priority patent/IL161885A0/xx
Priority to HK05101004.7A priority patent/HK1070053B/en
Priority to PT05021228T priority patent/PT1666462E/pt
Priority to NZ533136A priority patent/NZ533136A/en
Priority to SG200602676-9A priority patent/SG146442A1/en
Priority to CA2466965A priority patent/CA2466965C/en
Priority to DK02785439T priority patent/DK1445252T3/da
Priority to DE60209779T priority patent/DE60209779T2/de
Priority to EP05021228A priority patent/EP1666462B1/en
Priority to SI200230302T priority patent/SI1445252T1/sl
Priority to PCT/ES2002/000518 priority patent/WO2003042175A1/es
Priority to HU0402317A priority patent/HUP0402317A2/hu
Priority to AT02785439T priority patent/ATE319684T1/de
Priority to KR10-2004-7007155A priority patent/KR20040071685A/ko
Priority to PT02785439T priority patent/PT1445252E/pt
Priority to ES02785439T priority patent/ES2259387T3/es
Priority to EP02785439A priority patent/EP1445252B1/en
Priority to ARP020104303A priority patent/AR037288A1/es
Priority to RU2004117850/04A priority patent/RU2293082C2/ru
Priority to DE60232029T priority patent/DE60232029D1/de
Priority to TW091132989A priority patent/TWI275585B/zh
Priority to US10/293,206 priority patent/US7105515B2/en
Publication of ES2187300A1 publication Critical patent/ES2187300A1/es
Priority to ES200401084A priority patent/ES2249129B2/es
Priority to EC2004005105A priority patent/ECSP045105A/es
Priority to IS7263A priority patent/IS7263A/is
Priority to ZA200404073A priority patent/ZA200404073B/en
Priority to CO04048713A priority patent/CO5590895A2/es
Priority to MA27723A priority patent/MA27093A1/fr
Priority to NO20042478A priority patent/NO20042478L/no
Application granted granted Critical
Publication of ES2187300B1 publication Critical patent/ES2187300B1/es
Priority to US10/933,951 priority patent/US7176200B2/en
Priority to RU2005136355/04A priority patent/RU2005136355A/ru
Priority to CY20061100709T priority patent/CY1105362T1/el
Priority to US11/487,745 priority patent/US7498328B2/en
Priority to US11/707,571 priority patent/US7452881B2/en
Priority to IS8698A priority patent/IS8698A/is
Priority to IL193234A priority patent/IL193234A0/en
Priority to JP2009223711A priority patent/JP5132649B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
ES200102517A 2001-11-14 2001-11-14 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. Expired - Fee Related ES2187300B1 (es)

Priority Applications (49)

Application Number Priority Date Filing Date Title
ES200102517A ES2187300B1 (es) 2001-11-14 2001-11-14 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
UA20040604587A UA78252C2 (en) 2001-11-14 2002-08-11 Sulphonamide derivatives, methods of preparation thereof and application as pharmaceutical compositions
BR0214243-0A BR0214243A (pt) 2001-11-14 2002-11-08 Derivado de sulfonamida processo para a preparação de um derivado de sulfonamida e seus sais fisiologicamente aceitáveis, composição farmacêutica e uso de um derivado de sulfonamida
MXPA04004601A MXPA04004601A (es) 2001-11-14 2002-11-08 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
HR20040429A HRP20040429B1 (hr) 2001-11-14 2002-11-08 Derivati sulfonamida, njihova priprema i upotrebakao lijekova
YU41104A RS41104A (sr) 2001-11-14 2002-11-08 Sulfonamid derivati, njihovo pripremanje i upotreba kao medikamenata
NZ543393A NZ543393A (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
ES05021228T ES2322068T3 (es) 2001-11-14 2002-11-08 Derivados de n-(1h-indol-5-il)naftaleno-1-sulfonamida y compuestos relacionados como antagonistas del receptor de serotonina 5-ht6 para el tratamiento de trastornos del sistema nervioso central.
PL02373894A PL373894A1 (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
JP2003544012A JP4416505B2 (ja) 2001-11-14 2002-11-08 スルホンアミド誘導体類と、その製造方法及び医薬としての応用
AT05021228T ATE428694T1 (de) 2001-11-14 2002-11-08 N-ä1h-indol-5-ylünaphthalin-1-sulphonamid- derivate und verwandte verbindungen als serotonin 5-ht6 rezeptor antagonisten zur behandlung von erkrankungen des zentralen nervensystems
CNB028240804A CN1271052C (zh) 2001-11-14 2002-11-08 磺酰胺衍生物、它们的制备和作为药物的用途
IL16188502A IL161885A0 (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
HK05101004.7A HK1070053B (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
PT05021228T PT1666462E (pt) 2001-11-14 2002-11-08 Derivados de n-[1h-indol-5-il]-naftaleno-1-sulfonamida e compostos associados enquanto antagonistas do receptor 5- ht6 de serotonina para o tratamento de distúrbios do sistema nervoso central
NZ533136A NZ533136A (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
SG200602676-9A SG146442A1 (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, their preparation and use as medicaments
CA2466965A CA2466965C (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, their preparation and use as medicaments
DK02785439T DK1445252T3 (da) 2001-11-14 2002-11-08 Sulfonamid-derivater, deres fremstilling og anvendelse som medikamenter
DE60209779T DE60209779T2 (de) 2001-11-14 2002-11-08 Sulfonamidderivate, deren herstellung und deren verwendung als medikamente
EP05021228A EP1666462B1 (en) 2001-11-14 2002-11-08 N-[1h-indol-5-yl]naphthalene-1-sulphonamide derivatives and related compounds as serotonin 5-ht6 receptor antagonists for the treatment of disorders of the central nervous system
SI200230302T SI1445252T1 (sl) 2001-11-14 2002-11-08 Derivati sulfonamida, njihova priprava in uporabale teh kot zdravilo
PCT/ES2002/000518 WO2003042175A1 (es) 2001-11-14 2002-11-08 Derivados de sulfonamidas, su preparación y su aplicación como medicamentos
HU0402317A HUP0402317A2 (hu) 2001-11-14 2002-11-08 Szulfonamidszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AT02785439T ATE319684T1 (de) 2001-11-14 2002-11-08 Sulfonamidderivate, deren herstellung und deren verwendung als medikamente
KR10-2004-7007155A KR20040071685A (ko) 2001-11-14 2002-11-08 설폰아마이드 유도체, 이들의 제조 방법 및 약물로서이들의 용도
PT02785439T PT1445252E (pt) 2001-11-14 2002-11-08 Derivados de sulfonamida, a sua preparacao e aplicacao co medicamentos
ES02785439T ES2259387T3 (es) 2001-11-14 2002-11-08 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
EP02785439A EP1445252B1 (en) 2001-11-14 2002-11-08 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
ARP020104303A AR037288A1 (es) 2001-11-14 2002-11-08 Compuestos derivados de sulfonamidas, procedimiento para la obtencion, composicion farmaceutica y uso para la elaboracion de un medicamento
RU2004117850/04A RU2293082C2 (ru) 2001-11-14 2002-11-08 Производные сульфонамида, их получение и применение в качестве лекарственных средств
DE60232029T DE60232029D1 (de) 2001-11-14 2002-11-08 N-ä1h-indol-5-ylünaphthalin-1-sulphonamid-derivate und verwandte verbindungen als serotonin 5-ht6 rezeptor antagonisten zur behandlung von erkrankungen des zentralen nervensystems
TW091132989A TWI275585B (en) 2001-11-14 2002-11-11 Derivatives of sulphonamides, their preparation and use as medicaments
US10/293,206 US7105515B2 (en) 2001-11-14 2002-11-13 Derivatives of sulphonamides, their preparation and use as medicaments
ES200401084A ES2249129B2 (es) 2001-11-14 2004-05-06 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
EC2004005105A ECSP045105A (es) 2001-11-14 2004-05-13 Derivados de sulfonamidas, su preparacion y su aplicación como medicamentos
IS7263A IS7263A (is) 2001-11-14 2004-05-13 Súlfónamíðaafleiður, framleiðsla þeirra og notkunþeirra sem lyfja
ZA200404073A ZA200404073B (en) 2001-11-14 2004-05-25 Sulphonamide derivatives, the preperation thereof and the application of same as medicaments
CO04048713A CO5590895A2 (es) 2001-11-14 2004-05-26 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos
MA27723A MA27093A1 (fr) 2001-11-14 2004-06-07 Derives de sulfonamides, leur preparation et leur application comme medicaments.
NO20042478A NO20042478L (no) 2001-11-14 2004-06-14 Sulfonamid-derivater, deres fremstilling og anvendelse som medikamenter
US10/933,951 US7176200B2 (en) 2001-11-14 2004-09-03 Derivatives of sulphonamides, their preparation and use as medicaments
RU2005136355/04A RU2005136355A (ru) 2001-11-14 2005-11-22 Производные сульфонамида, их получение и применение в качестве лекарственных средств
CY20061100709T CY1105362T1 (el) 2001-11-14 2006-06-02 Παραγωγα σουλφοναμιδιου, η παρασκευη τους και η εφαρμογη αυτων ως φαρμακα
US11/487,745 US7498328B2 (en) 2001-11-14 2006-07-17 Derivatives of sulphonamides, their preparation and use as medicaments
US11/707,571 US7452881B2 (en) 2001-11-14 2007-02-16 Derivatives of sulphonamides, their preparation and use as medicaments
IS8698A IS8698A (is) 2001-11-14 2007-12-05 Súlfónamíðaafleiður, framleiðsla þeirra og notkunþeirra sem lyfja
IL193234A IL193234A0 (en) 2001-11-14 2008-08-04 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
JP2009223711A JP5132649B2 (ja) 2001-11-14 2009-09-29 スルホンアミド誘導体類と、その製造方法及び医薬としての応用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200102517A ES2187300B1 (es) 2001-11-14 2001-11-14 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
ES2187300A1 ES2187300A1 (es) 2003-05-16
ES2187300B1 true ES2187300B1 (es) 2004-06-16

Family

ID=8499446

Family Applications (4)

Application Number Title Priority Date Filing Date
ES200102517A Expired - Fee Related ES2187300B1 (es) 2001-11-14 2001-11-14 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
ES02785439T Expired - Lifetime ES2259387T3 (es) 2001-11-14 2002-11-08 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
ES05021228T Expired - Lifetime ES2322068T3 (es) 2001-11-14 2002-11-08 Derivados de n-(1h-indol-5-il)naftaleno-1-sulfonamida y compuestos relacionados como antagonistas del receptor de serotonina 5-ht6 para el tratamiento de trastornos del sistema nervioso central.
ES200401084A Expired - Fee Related ES2249129B2 (es) 2001-11-14 2004-05-06 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES02785439T Expired - Lifetime ES2259387T3 (es) 2001-11-14 2002-11-08 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
ES05021228T Expired - Lifetime ES2322068T3 (es) 2001-11-14 2002-11-08 Derivados de n-(1h-indol-5-il)naftaleno-1-sulfonamida y compuestos relacionados como antagonistas del receptor de serotonina 5-ht6 para el tratamiento de trastornos del sistema nervioso central.
ES200401084A Expired - Fee Related ES2249129B2 (es) 2001-11-14 2004-05-06 Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.

Country Status (33)

Country Link
US (4) US7105515B2 (enExample)
EP (2) EP1666462B1 (enExample)
JP (2) JP4416505B2 (enExample)
KR (1) KR20040071685A (enExample)
CN (1) CN1271052C (enExample)
AR (1) AR037288A1 (enExample)
AT (2) ATE428694T1 (enExample)
BR (1) BR0214243A (enExample)
CA (1) CA2466965C (enExample)
CO (1) CO5590895A2 (enExample)
CY (1) CY1105362T1 (enExample)
DE (2) DE60232029D1 (enExample)
DK (1) DK1445252T3 (enExample)
EC (1) ECSP045105A (enExample)
ES (4) ES2187300B1 (enExample)
HR (1) HRP20040429B1 (enExample)
HU (1) HUP0402317A2 (enExample)
IL (2) IL161885A0 (enExample)
IS (2) IS7263A (enExample)
MA (1) MA27093A1 (enExample)
MX (1) MXPA04004601A (enExample)
NO (1) NO20042478L (enExample)
NZ (2) NZ533136A (enExample)
PL (1) PL373894A1 (enExample)
PT (2) PT1445252E (enExample)
RS (1) RS41104A (enExample)
RU (2) RU2293082C2 (enExample)
SG (1) SG146442A1 (enExample)
SI (1) SI1445252T1 (enExample)
TW (1) TWI275585B (enExample)
UA (1) UA78252C2 (enExample)
WO (1) WO2003042175A1 (enExample)
ZA (1) ZA200404073B (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2187300B1 (es) * 2001-11-14 2004-06-16 Laboratorios Del Dr. Esteve, S.A. Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
JP2006525972A (ja) * 2003-05-09 2006-11-16 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ 食物摂取障害の予防および／または治療用の医薬品製造のためのスルホンアミド誘導体の使用
ES2222832B1 (es) * 2003-07-30 2006-02-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2228268B1 (es) * 2003-07-30 2006-07-01 Laboratorios Del Dr. Esteve, S.A. Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6.
ES2222827B1 (es) * 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2228267B1 (es) * 2003-07-30 2006-07-01 Laboratorios Del Dr. Esteve, S.A. Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6.
ES2222829B1 (es) * 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2222830B1 (es) * 2003-07-30 2006-02-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 7-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
ATE430752T1 (de) * 2004-01-02 2009-05-15 Suven Life Sciences Ltd Neue indenoä2,1-aüindene und isoindolä2,1-aüindol
ES2246721B1 (es) * 2004-08-10 2007-03-16 Laboratorios Del Dr. Esteve, S.A. Compuestos indolicos sustituidos, su preparacion y su uso como medicamentos.
EP1632491A1 (en) * 2004-08-30 2006-03-08 Laboratorios Del Dr. Esteve, S.A. Substituted indole compounds and their use as 5-HT6 receptor modulators
ATE489138T1 (de) 2005-04-13 2010-12-15 Neuraxon Inc Substituierte indolverbindungen mit nos-hemmender aktivität
JP5026690B2 (ja) * 2005-11-21 2012-09-12 株式会社ジャパンディスプレイイースト 表示装置
NZ568910A (en) * 2006-01-24 2011-04-29 Lilly Co Eli Indole sulfonamide modulators of progesterone receptors
EP1837332A1 (en) * 2006-03-23 2007-09-26 Laboratorios Del Dr. Esteve, S.A. Substituted tetrahydroisoquinoline compounds, their preparation and use in medicaments
ZA200809659B (en) * 2006-04-13 2010-03-31 Neuraxon Inc 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
EP1902733A1 (en) * 2006-09-19 2008-03-26 Laboratorios Del Dr. Esteve, S.A. Combination of a NMDA-receptor ligand and a compound with 5-HT6 receptor affinity
EP1953153A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
EP1953141A1 (en) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Aryl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
EP2018861A1 (en) * 2007-07-26 2009-01-28 Laboratorios del Dr. Esteve S.A. 5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain
EP2020230B1 (en) 2007-08-01 2011-01-19 Laboratorios del Dr. Esteve S.A. Combination of at least two 5-HT6-Ligands
EP2036888A1 (en) * 2007-09-17 2009-03-18 Laboratorios del Dr. Esteve S.A. Naphthyl-substituted sulfonamides
WO2009062318A1 (en) * 2007-11-16 2009-05-22 Neuraxon, Inc. 3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
US20090163451A1 (en) * 2007-11-16 2009-06-25 Frank Porreca Methods for treating visceral pain
EA201000808A1 (ru) * 2007-11-16 2011-04-29 Ньюраксон, Инк. Индольные соединения и способы лечения висцеральной боли
EP2116547A1 (en) 2008-05-09 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands
EP2116546A1 (en) * 2008-05-09 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. Substituted N-phenyl-2,3-dihydroimidazo[2,1-b]thiazole-5-sulfonamide derivatives as 5-HT6 ligands
CU24398B1 (es) * 2013-08-02 2019-04-04 Pfizer 3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2
MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1601070A (en) * 1966-08-29 1970-08-10 Sulphamidotryptamines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
US5962473A (en) * 1996-08-16 1999-10-05 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US6380201B1 (en) * 1997-08-05 2002-04-30 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
ES2187300B1 (es) * 2001-11-14 2004-06-16 Laboratorios Del Dr. Esteve, S.A. Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1601070A (en) * 1966-08-29 1970-08-10 Sulphamidotryptamines

Also Published As

Publication number Publication date
ES2249129B2 (es) 2007-08-16
SG146442A1 (en) 2008-10-30
CN1271052C (zh) 2006-08-23
MXPA04004601A (es) 2004-08-13
ES2187300A1 (es) 2003-05-16
EP1445252B1 (en) 2006-03-08
RU2005136355A (ru) 2007-05-27
US7105515B2 (en) 2006-09-12
EP1666462A1 (en) 2006-06-07
ES2322068T3 (es) 2009-06-16
DE60232029D1 (de) 2009-05-28
US20030191124A1 (en) 2003-10-09
ES2259387T3 (es) 2006-10-01
MA27093A1 (fr) 2004-12-20
ATE428694T1 (de) 2009-05-15
ES2249129A1 (es) 2006-03-16
IL161885A0 (en) 2005-11-20
CA2466965C (en) 2011-09-06
UA78252C2 (en) 2007-03-15
US20050032791A1 (en) 2005-02-10
EP1445252A1 (en) 2004-08-11
US20070167448A1 (en) 2007-07-19
PL373894A1 (en) 2005-09-19
IL193234A0 (en) 2009-02-11
JP2009298819A (ja) 2009-12-24
HUP0402317A2 (hu) 2005-02-28
IS8698A (is) 2007-12-05
ATE319684T1 (de) 2006-03-15
NO20042478L (no) 2004-08-12
KR20040071685A (ko) 2004-08-12
HRP20040429A2 (en) 2005-06-30
CO5590895A2 (es) 2005-12-30
PT1445252E (pt) 2006-07-31
WO2003042175A1 (es) 2003-05-22
CN1599718A (zh) 2005-03-23
DE60209779D1 (de) 2006-05-04
IS7263A (is) 2004-05-13
CA2466965A1 (en) 2003-05-22
DE60209779T2 (de) 2006-11-16
US20060258653A1 (en) 2006-11-16
US7498328B2 (en) 2009-03-03
JP5132649B2 (ja) 2013-01-30
NZ543393A (en) 2007-04-27
DK1445252T3 (da) 2006-06-19
JP2005513016A (ja) 2005-05-12
PT1666462E (pt) 2009-05-07
ECSP045105A (es) 2004-07-23
TW200407306A (en) 2004-05-16
SI1445252T1 (sl) 2006-06-30
CY1105362T1 (el) 2010-03-03
HRP20040429B1 (hr) 2007-10-31
TWI275585B (en) 2007-03-11
JP4416505B2 (ja) 2010-02-17
EP1666462B1 (en) 2009-04-15
HK1070053A1 (en) 2005-06-10
ZA200404073B (en) 2006-05-31
RU2293082C2 (ru) 2007-02-10
BR0214243A (pt) 2004-12-21
RU2004117850A (ru) 2005-11-20
RS41104A (sr) 2006-10-27
AR037288A1 (es) 2004-11-03
NZ533136A (en) 2006-01-27
US7452881B2 (en) 2008-11-18
US7176200B2 (en) 2007-02-13

Similar Documents

Publication Publication Date Title
ECSP045105A (es) Derivados de sulfonamidas, su preparacion y su aplicación como medicamentos
PA8592201A1 (es) Nuevos derivados de fluoroglicosidos aromaticos, medicamentos que contienen estos compuestos y sus usos
PA8592301A1 (es) Nuevos derivados de fluoroglicosidos heterociclicos, medicamentos que contienen estos compuestos, y el uso de los mismos
UY27891A1 (es) Nuevos derivados de glicosido de tiofeno, procedimientos para la preparación de los mismos, medicamentos que contienen estos compuestos, y el uso de los mismos.
PA8570901A1 (es) Derivados de acil-4-carboxifenilurea, procedimientos para su preparacion y su uso
UY28732A1 (es) Derivados de acido 7-fenilamino-4-quinolona-3-carboxilico, procesos para su preparación y su uso como medicamentos.
UY31481A1 (es) Nuevos derivados de pirimidina, procesos de preparacion, composiciones farmacéuticas conteniéndolos y aplicaciones
CU23105A3 (es) DERIVADOS NOVEDOSOS DEL áCIDO AMINODICARBOXILICO CON PROPIEDADES FARMACéUTICAS
BR122019010008B8 (pt) derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
UY30681A1 (es) Compuestos de piridinamida que contienen carboxi, sales farmacéuticamente aceptables, procedimientos para la preparacion de los mismos, composiciones que los contienen y sus usos.
AR055076A1 (es) Derivados de1,1-dioxido de 1,4-benzotiazepina,procedimiento para prepararlos,composiciones farmaceuticas que los contienen y usos en terapeutica.
CR7069A (es) Derivados de pirazol para el tratamiento de vih
UY27350A1 (es) Azaindoles
CU22995A3 (es) Derivados de pirazolinas, su preparación y su aplicación como medicamentos
MX9501848A (es) Nuevos compuestos polienicos, composiciones farmaceuticas y cosmeticas que los contienen y sus usos.
HN2003000185A (es) Difenilazetidinonas sustituidas en grupo acido, procedimiemto para su preparacion, medicamentos que comprenden estso compuestos y su uso.
CU23415B7 (es) Derivados de 2,6- quinolinilo y 2,6- naftilo, procesos para su preparación y sus usos
UY30856A1 (es) Nuevos derivados de 2,4 dianilinopirimidinas, su preparacion, como medicamentos, composiciones farmacéuticas y principalmente como inhibidores de ikk
CR9469A (es) Derivados de urea, metodos para su fabricacion y usos para los mismos
ECSP066330A (es) Derivados de 1-sulfonilindol, su preparación y su uso como lingados de 5-ht-6
ECSP066325A (es) Derivados de 5-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6
UY28547A1 (es) Derivados de disulfuro, sulfuro, sulfóxido y sulfona de azúcares cíclicos y sus usos.
UY28357A1 (es) Derivados de benzimidazol, composiciones que los contienen, preparación de los mismos y sus usos
ECSP066322A (es) Derivados de 4-indolilsulfonamidas, su preparación y su uso como moduladores de 5-ht-6
BR0312318A (pt) Compostos, uso de um ou mais compostos, composição farmacêutica, composição cosmética e usos cosméticos

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20030516

Kind code of ref document: A1

FG2A Definitive protection

Ref document number: 2187300B1

Country of ref document: ES

FD2A Announcement of lapse in spain

Effective date: 20190521

FD2A Announcement of lapse in spain

Effective date: 20190604