ES2186923T3 - Derivados del 2-carboniltiazol y su utilizacion. - Google Patents
Derivados del 2-carboniltiazol y su utilizacion.Info
- Publication number
- ES2186923T3 ES2186923T3 ES97940436T ES97940436T ES2186923T3 ES 2186923 T3 ES2186923 T3 ES 2186923T3 ES 97940436 T ES97940436 T ES 97940436T ES 97940436 T ES97940436 T ES 97940436T ES 2186923 T3 ES2186923 T3 ES 2186923T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- rent
- atom
- piperidino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 7
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 5
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical class C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 238000009313 farming Methods 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UN DERIVADO DE 2 CARBONILTIADIAZOL REPRESENTADO MEDIANTE LA FORMULA (I): [DONDE CADA UNO DE AR 1 Y AR 2 REPRESENTA UN GRUPO FENILO, UN GRUPO FENILO CON UNO O DOS SUSTITUYENTES SELECCIONADOS A PARTIR DE UN ATOMO DE HALOGENO, UN GRUPO ALQUILO DE 1 A 5 ATOMOS DE CARBONO, UN GRUPO TRIFLUOROMETILO, UN GRUPO ALCOXI DE 1 A 5 ATOMOS DE CARBONO Y UN GRUPO HIDROXILO O UN GRUPO TIENILO; R 1 REPRESENTA UN GRUPO ALCOXI CON 1 A 5 ATOMOS DE CARBONO, UN GRUPO HIDROXILO O UN GRUPO AMINO REPRESENTADO POR LA FORMULA N(R 3 )R 4 (DONDE CADA UNO DE R 3 Y R 4 REPR ESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 5 ATOMOS DE CARBONO, O R 3 Y R 4 , JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS, FORMAN UN GRUPO PIRROLIDINO, PIPERIDINO, MORFOLINO O PIPERAZINO, O UN GRUPO PIRROLIDINO, PIPERIDINO, MORFOLINO O PIPERAZINO, QUE TIENE DE UNO A CUATRO SUSTITUYENTES SELECCIONADOS A PARTIR DE UN GRUPO ALQUILO DE 1 A 5 ATOMOS DE CARBONO, UN GRUPO ALCOXI DE 1 A 5 ATOMOS DE CARBONO,Y UN GRUPO HIDROXILO); Y 1 -Y 2 REPRESENTA CH - CO O C = C(R 2 ) (DONDE R 2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 5 ATOMOS DE CARBONO); Y N ES UN ENTERO DE 1 A 4] O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. LA INVENCION PROPORCIONA ASIMISMO UN MEDICAMENTO QUE COMPRENDE EL DERIVADO 2 - CARBONILTIAZOL DE FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, Y UN ANTAGONISTA DEL RECEPTOR DE DOPAMINA D 4 QUE CONTIENE DICHO COMPUESTO COMO INREDIENTE ACTIVO. DICHOS COMPUESTOS SON UTILES COMO FARMACOS PARA PREVENIR Y TRATAR ESTADOS MORBIDOS RELACIONADOS CON EL RECEPTOR D 4 , COMO LA ESQUIZOFRENIA Y EL COMPORTAMIENTO PROBLEMATICO PRODUCIDO POR ACCIDENTES CEREBROVASCULARES, COMO LA DEMENCIA SENIL, Y TAMBIEN SE UTILIZAN COMO FARMACOS QUE NO INDUCEN ALTERACIONES EXTRAPIRAMIDALES COMO EFECTOS SECUNDARIOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24941596 | 1996-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2186923T3 true ES2186923T3 (es) | 2003-05-16 |
Family
ID=17192642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97940436T Expired - Lifetime ES2186923T3 (es) | 1996-09-20 | 1997-09-19 | Derivados del 2-carboniltiazol y su utilizacion. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6166033A (es) |
| EP (1) | EP0940401B1 (es) |
| KR (1) | KR20000048480A (es) |
| CN (1) | CN1088707C (es) |
| AT (1) | ATE227286T1 (es) |
| AU (1) | AU718519B2 (es) |
| CA (1) | CA2267258A1 (es) |
| DE (1) | DE69716939T2 (es) |
| DK (1) | DK0940401T3 (es) |
| ES (1) | ES2186923T3 (es) |
| PT (1) | PT940401E (es) |
| WO (1) | WO1998012195A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100394083B1 (ko) * | 2000-12-04 | 2003-08-06 | 학교법인 성신학원 | 도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규4,5-디히드로이소옥사졸릴알킬피페라진 유도체와, 이의제조방법 |
| KR100394086B1 (ko) * | 2000-12-04 | 2003-08-06 | 한국과학기술연구원 | 도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규이소옥사졸릴알킬피페라진 유도체와, 이의 제조방법 |
| WO2008128189A1 (en) * | 2007-04-13 | 2008-10-23 | The Penn State Research Foundation | Anti-cancer compositions and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
| DE3923675A1 (de) * | 1989-07-18 | 1991-01-24 | Basf Ag | Amonoalkylsubstituierte 2-aminothiazole und diese enthaltende therapeutische mittel |
| DE4119757A1 (de) * | 1991-06-15 | 1992-12-17 | Basf Ag | Aminoalkylsubstituierte thiazolin-2-one, ihre herstellung und verwendung |
| WO1996029330A1 (fr) * | 1995-03-22 | 1996-09-26 | Taisho Pharmaceutical Co., Ltd. | Derives de la thiazole |
-
1997
- 1997-09-19 EP EP97940436A patent/EP0940401B1/en not_active Expired - Lifetime
- 1997-09-19 CN CN97199832A patent/CN1088707C/zh not_active Expired - Fee Related
- 1997-09-19 PT PT97940436T patent/PT940401E/pt unknown
- 1997-09-19 WO PCT/JP1997/003342 patent/WO1998012195A1/ja not_active Application Discontinuation
- 1997-09-19 US US09/269,021 patent/US6166033A/en not_active Expired - Fee Related
- 1997-09-19 CA CA002267258A patent/CA2267258A1/en not_active Abandoned
- 1997-09-19 AU AU42223/97A patent/AU718519B2/en not_active Ceased
- 1997-09-19 AT AT97940436T patent/ATE227286T1/de not_active IP Right Cessation
- 1997-09-19 DK DK97940436T patent/DK0940401T3/da active
- 1997-09-19 DE DE69716939T patent/DE69716939T2/de not_active Expired - Fee Related
- 1997-09-19 KR KR1019990702355A patent/KR20000048480A/ko not_active Application Discontinuation
- 1997-09-19 ES ES97940436T patent/ES2186923T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6166033A (en) | 2000-12-26 |
| KR20000048480A (ko) | 2000-07-25 |
| CA2267258A1 (en) | 1998-03-26 |
| PT940401E (pt) | 2003-03-31 |
| EP0940401A4 (en) | 2001-04-11 |
| DE69716939T2 (de) | 2003-07-03 |
| EP0940401B1 (en) | 2002-11-06 |
| CN1088707C (zh) | 2002-08-07 |
| WO1998012195A1 (fr) | 1998-03-26 |
| AU718519B2 (en) | 2000-04-13 |
| DE69716939D1 (de) | 2002-12-12 |
| CN1237971A (zh) | 1999-12-08 |
| DK0940401T3 (da) | 2003-03-03 |
| EP0940401A1 (en) | 1999-09-08 |
| AU4222397A (en) | 1998-04-14 |
| ATE227286T1 (de) | 2002-11-15 |
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