ES2186621T3 - Derivados de alfa-azaciclometilquinoleina, su preparacion y su aplicacion en terapeutica. - Google Patents

Derivados de alfa-azaciclometilquinoleina, su preparacion y su aplicacion en terapeutica.

Info

Publication number
ES2186621T3
ES2186621T3 ES00901659T ES00901659T ES2186621T3 ES 2186621 T3 ES2186621 T3 ES 2186621T3 ES 00901659 T ES00901659 T ES 00901659T ES 00901659 T ES00901659 T ES 00901659T ES 2186621 T3 ES2186621 T3 ES 2186621T3
Authority
ES
Spain
Prior art keywords
oil
alkenyl succinates
azaciclometilquinoleina
alfa
therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00901659T
Other languages
English (en)
Inventor
Christophe Philippo
Alain Braun
Philippe R Bovy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2186621T3 publication Critical patent/ES2186621T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula (I)**Fórmula** en la que: A representa ya sea un átomo de hidrógeno ya sea un grupo hidroxilo, B representa una pirrolidin-2-il (E) o 2-piperidil (D), **Fórmula** R1 representa un átomo de hidrógeno, un grupo C1_6alquilo, C2_6alquenilo, C1-2 perfluoroalquilo o C1-6 fluoroalquilo, R2, R3 o R4 representan, cada uno, independientemente unos de otros, un átomo de hidrógeno, un grupo C1-6 alquilo o un grupo C2-6 alquenilo, o R1 y R2 pueden también formar conjuntamente una cadena C1-6 alquileno o una cadena C3-6 alquenileno, R5 representa un grupo C1-6 alquilo, R6 representa un átomo de hidrógeno, un Grupo C1-6 alquilo, un grupo C2-6 alquenilo, C3-6 cicloalquilo, C3-6 cicloalquenilo o un bencilo, y ¿n¿ representa 0, 1 ó 2, y eventualmente sus sales.
ES00901659T 1999-02-02 2000-01-28 Derivados de alfa-azaciclometilquinoleina, su preparacion y su aplicacion en terapeutica. Expired - Lifetime ES2186621T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9901145A FR2789076B1 (fr) 1999-02-02 1999-02-02 Derives de alpha-azacyclomethyl quinoleine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES2186621T3 true ES2186621T3 (es) 2003-05-16

Family

ID=9541475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00901659T Expired - Lifetime ES2186621T3 (es) 1999-02-02 2000-01-28 Derivados de alfa-azaciclometilquinoleina, su preparacion y su aplicacion en terapeutica.

Country Status (11)

Country Link
US (2) US6461625B1 (es)
EP (1) EP1150969B1 (es)
JP (1) JP2002540067A (es)
AT (1) ATE228125T1 (es)
AU (1) AU2298700A (es)
DE (1) DE60000820T2 (es)
DK (1) DK1150969T3 (es)
ES (1) ES2186621T3 (es)
FR (1) FR2789076B1 (es)
PT (1) PT1150969E (es)
WO (1) WO2000046219A1 (es)

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FR2811564B1 (fr) * 2000-07-13 2002-12-27 Oreal Nanoemulsion contenant des polymeres non ioniques, et ses utilisations notamment dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CN100368047C (zh) * 2002-12-27 2008-02-13 住友化学株式会社 结晶方法和结晶装置
WO2006098966A2 (en) * 2005-03-09 2006-09-21 Combe Incorporated Stable mixed emulsions comprising semisolid dispersions of at least two discrete and distinctly different particle size ranges
FR2885797B1 (fr) * 2005-05-17 2007-07-27 Oreal Particules d'huile gelifiee comportant au moins un filtre solaire hydrophobe
US20060263438A1 (en) * 2005-05-17 2006-11-23 L'oreal Gelled oil particles for targeting sebaceous glands and/or hair follicles
TWI402034B (zh) * 2005-07-28 2013-07-21 Dow Agrosciences Llc 具有被層狀液晶覆膜包覆之油球之水包油乳化劑之農用組成物
CA2600288A1 (en) * 2005-09-19 2007-04-12 Combe Incorporated Stable emulsion systems with high salt tolerance
EP2252145B1 (en) * 2008-02-04 2016-04-06 Dow AgroSciences LLC Stabilized oil-in-water emulsions including agriculturally active ingredients
US20090227460A1 (en) * 2008-03-07 2009-09-10 Dow Agrosciences Llc Stabilized oil-in-water emulsions including meptyl dinocap
PT2271212T (pt) * 2008-03-07 2017-12-06 Dow Agrosciences Llc Emulsões óleo-em-água estabilizadas incluíndo ingredientes activos para agricultura
EP2273872B1 (en) * 2008-03-07 2015-11-04 Dow AgroSciences LLC Stabilized oil-in-water emulsions including agriculturally active ingredients
WO2010091199A2 (en) 2009-02-06 2010-08-12 The Regents Of The University Of California Calcium-binding agents induce hair growth and/or nail growth
CN102638987A (zh) * 2009-10-07 2012-08-15 默沙东公司 使用β3肾上腺素能受体激动剂和抗毒蕈碱药剂的组合疗法
US20110229516A1 (en) * 2010-03-18 2011-09-22 The Clorox Company Adjuvant phase inversion concentrated nanoemulsion compositions
AU2012205552B2 (en) 2011-01-14 2015-08-20 Dow Agrosciences Llc Agricultural compositions comprising oil-in-water emulsions
CA2867891C (en) 2012-03-19 2021-09-14 Buck Institute For Research On Aging App specific bace inhibitors (asbis) and uses thereof
ES2769578T3 (es) 2013-02-12 2020-06-26 Buck Inst Res Aging Hidantoínas que modulan el procesamiento de APP mediado por BACE
CN105636446B (zh) 2013-10-17 2018-07-13 美国陶氏益农公司 制备杀虫化合物的方法
JP2016539092A (ja) 2013-10-17 2016-12-15 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
MX2016004945A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
KR20160074540A (ko) 2013-10-17 2016-06-28 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
EP3174856A4 (en) 2014-07-31 2018-01-10 Dow AgroSciences LLC Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
BR112017002735A2 (pt) 2014-08-19 2017-12-19 Dow Agrosciences Llc processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
CA2960985A1 (en) 2014-09-12 2016-03-17 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
US10233155B2 (en) 2016-12-29 2019-03-19 Dow Agrosciences Llc Processes for the preparation of pesticide compounds
CN110139853B (zh) 2016-12-29 2023-06-16 美国陶氏益农公司 用于制备杀有害生物化合物的方法
CA3049212A1 (en) 2017-01-05 2018-07-12 The Regents Of The University Of California Pac1 receptor agonists (maxcaps) and uses thereof
GB2584009B (en) 2017-08-28 2022-03-23 Revagenix Inc Aminoglycosides and uses thereof
WO2019194858A1 (en) 2018-04-03 2019-10-10 Achaogen, Inc. Modular synthesis of aminoglycosides
KR102643707B1 (ko) 2019-01-22 2024-03-04 에오비안 파마슈티컬스, 인크. Mtorc 조절제 및 이의 용도
WO2023166488A1 (en) 2022-03-04 2023-09-07 Revagenix, Inc. Broad spectrum aminoglycosides and uses thereof

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JP2785981B2 (ja) * 1989-11-20 1998-08-13 株式会社資生堂 乳化組成物
US5183601A (en) * 1990-06-07 1993-02-02 Kao Corporation Detergent composition containing polyethylenimine co-polymer
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FR2730932B1 (fr) * 1995-02-27 1997-04-04 Oreal Nanoemulsion transparente a base de lipides amphiphiles non-ioniques fluides et utilisation en cosmetique ou en dermopharmacie
FR2750044A1 (fr) 1996-06-21 1997-12-26 Oreal Utilisation de derives de l'anhydride succinique dans des compositions de nettoyage de la peau
FR2756564B1 (fr) * 1996-12-04 2004-05-14 Synthelabo Derives d'acide quinoleine-8-carboxylique, leur preparation et leur application en therapeutique
WO1998033793A1 (fr) * 1997-01-30 1998-08-06 Sanofi-Synthelabo DERIVES DE α-AZACYCLOMETHYL BENZOTHIOPHENE ET DE α-AZACYCLOMETHYL BENZOFURANE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Also Published As

Publication number Publication date
FR2789076A1 (fr) 2000-08-04
US6461625B1 (en) 2002-10-08
DE60000820D1 (de) 2003-01-02
EP1150969B1 (fr) 2002-11-20
US6413984B1 (en) 2002-07-02
DE60000820T2 (de) 2003-09-04
FR2789076B1 (fr) 2001-03-02
EP1150969A1 (fr) 2001-11-07
WO2000046219A1 (fr) 2000-08-10
DK1150969T3 (da) 2003-03-17
PT1150969E (pt) 2003-03-31
ATE228125T1 (de) 2002-12-15
AU2298700A (en) 2000-08-25
JP2002540067A (ja) 2002-11-26

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