ES2095739T4 - Estabilizacion de emulsiones de fluorocarbono. - Google Patents
Estabilizacion de emulsiones de fluorocarbono.Info
- Publication number
- ES2095739T4 ES2095739T4 ES94901211T ES94901211T ES2095739T4 ES 2095739 T4 ES2095739 T4 ES 2095739T4 ES 94901211 T ES94901211 T ES 94901211T ES 94901211 T ES94901211 T ES 94901211T ES 2095739 T4 ES2095739 T4 ES 2095739T4
- Authority
- ES
- Spain
- Prior art keywords
- fluorocarbon
- mixture
- phase
- stabilization
- emulsions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
Abstract
EMULSIONES DE FLUOCARBUROS DE CONSERVACION ESTABLE QUE TIENE UNA FASE ACUOSA CONTINUA Y UNA FASE DE FLUOCARBUROS DISCONTINUA, EN DONDE LA FASE DE FLUOROCARBUROS CONTIENE UNA CANTIDAD PRINCIPAL DE UN PRIMER FLUOROCARBURO O MEZCLA DE FLUOCARBUROS Y UNA CANTIDAD MENOR DE UN SEGUNDO FLUOROCARBURO O MEZCLA DE FLUOROCARBUROS, EN DONDE EL SEGUNDO FLUOROCARBURO TIENE UN PESO MOLECULAR MAYOR QUE EL DEL PRIMER FLUOROCARBURO Y EL SEGUNDO FLUOROCARBURO INCLUYE UNA UNIDAD LIPOFILICA EN SU ESTRUCTURA, CON LO QUE EL SEGUNDO FLUOROCARBURO ACTUA PARA PROMOVER LA ESTABILIDAD DEL TAMAÑO DE LAS PARTICULAS DE LA EMULSION AL TIEMPO QUE PROPORCIONA UNOS TIEMPOS DE RETENCION EN LOS ORGANOS FAVORABLEMENTE CORTOS CUANDO SE ADMINISTRA A ANIMALES IN VIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/967,700 US5628930A (en) | 1992-10-27 | 1992-10-27 | Stabilization of fluorocarbon emulsions |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2095739T3 ES2095739T3 (es) | 1997-02-16 |
ES2095739T4 true ES2095739T4 (es) | 1997-04-01 |
Family
ID=25513189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94901211T Expired - Lifetime ES2095739T4 (es) | 1992-10-27 | 1993-10-27 | Estabilizacion de emulsiones de fluorocarbono. |
Country Status (11)
Country | Link |
---|---|
US (5) | US5628930A (es) |
EP (1) | EP0666736B1 (es) |
JP (2) | JP3854630B2 (es) |
AT (1) | ATE146358T1 (es) |
AU (1) | AU678418B2 (es) |
CA (1) | CA2146757C (es) |
DE (1) | DE69306810T2 (es) |
DK (1) | DK0666736T3 (es) |
ES (1) | ES2095739T4 (es) |
GR (1) | GR3022641T3 (es) |
WO (1) | WO1994009625A2 (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
US5628930A (en) * | 1992-10-27 | 1997-05-13 | Alliance Pharmaceutical Corp. | Stabilization of fluorocarbon emulsions |
US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
US5726209A (en) * | 1995-06-07 | 1998-03-10 | Alliance Pharmaceutical Corp. | Liquid fluorocarbon emulsion as a vascular nitric oxide reservoir |
FR2737972B1 (fr) * | 1995-08-24 | 1997-09-26 | Oreal | Emulsion ayant une texture aeree |
DE69831248T2 (de) * | 1997-02-28 | 2006-04-13 | The Regents Of The University Of California, Oakland | Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen |
US5814601A (en) * | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
DE10022541A1 (de) * | 2000-02-24 | 2001-09-13 | Hartmut Belis | Verfahren zur Oberflächenbearbeitung von Stahlteilen und damit hergestellte Stahlteile |
AU2000279747A1 (en) | 2000-07-20 | 2002-02-05 | Otkrytoe Aktsionernoe Obschestvo Nauchno-Proizvodstvennaya Firma "Perftoran" | Emulsion of perfluororganic compounds for medical purposes, method for producingsaid emulsion and methods for curing and preventing diseases with the aid of the emulsion |
US20030049511A1 (en) * | 2001-04-13 | 2003-03-13 | Rosalyn Ritts | Stabilized biocompatible membranes of block copolymers and fuel cells produced therewith |
US20030113606A1 (en) * | 2001-04-13 | 2003-06-19 | Rosalyn Ritts | Biocompatible membranes of block copolymers and fuel cells produced therewith |
US20030087144A1 (en) * | 2001-04-13 | 2003-05-08 | Hoi-Cheong Steve Sun | Enzymatic fuel cell with fixed dehydrogenase enzyme |
US20030031911A1 (en) * | 2001-04-13 | 2003-02-13 | Rosalyn Ritts | Biocompatible membranes and fuel cells produced therewith |
US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
US20080031809A1 (en) | 2006-07-18 | 2008-02-07 | Norbeck Joseph M | Controlling the synthesis gas composition of a steam methane reformer |
US7619012B2 (en) * | 2006-07-18 | 2009-11-17 | The Regents Of The University Of California | Method and apparatus for steam hydro-gasification in a fluidized bed reactor |
ES2305368T3 (es) * | 2002-05-10 | 2008-11-01 | THE PROCTER & GAMBLE COMPANY | Tisu estampado en relieve que tiene fibras superficiales sueltas y metodo para su produccion. |
JP3912206B2 (ja) * | 2002-07-05 | 2007-05-09 | 株式会社日立製作所 | 筒内直接燃料噴射装置用燃料ポンプ |
US7767232B2 (en) * | 2002-09-19 | 2010-08-03 | New York University | Control of nitric oxide bioactivity by perfluorocarbons |
ATE546136T1 (de) | 2002-10-11 | 2012-03-15 | Baxter Int | Kardioprotektions- und neuroprotektionsverfahren durch intravenöse verabreichung von halogenierten flüchtigen narkosemitteln |
CN1997691B (zh) * | 2003-09-23 | 2011-07-20 | 北卡罗来纳大学查珀尔希尔分校 | 光固化的全氟聚醚用作微流体器件中的新材料 |
EP1732485A2 (en) * | 2004-01-02 | 2006-12-20 | Wisconsin Alumni Research Foundation | Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers |
JP2007527784A (ja) * | 2004-02-13 | 2007-10-04 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | マイクロ流体デバイスを作製するための官能性材料及び新規方法 |
RU2259819C1 (ru) * | 2004-03-01 | 2005-09-10 | Кузнецова Ирина Николаевна | Эмульсия перфторорганических соединений медицинского назначения и способ её получения |
US7371714B2 (en) * | 2005-06-23 | 2008-05-13 | The United States Of America As Represented By The Secretary Of The Army | Chemical agent decontamination composition comprising a perfluorinated alkyl bromide |
US20070026024A1 (en) * | 2005-07-27 | 2007-02-01 | Drees Thomas C | Compositions and methods for emulsifying a pefluorocarbon with an oxygen-carrying surfactant |
EP1922364A4 (en) | 2005-08-09 | 2010-04-21 | Univ North Carolina | METHODS AND MATERIALS FOR MANUFACTURING MICROFLUIDIC DEVICES |
US20090117207A1 (en) * | 2005-11-29 | 2009-05-07 | Zoltani Csaba K | Methods and compositions for treatment of poison-caused pathology |
WO2007106213A2 (en) * | 2006-02-24 | 2007-09-20 | Dow Global Technologies Inc. | Emulsion of a liquid fluorinated oil phase in a liquid water phase |
AU2007249200B2 (en) * | 2006-05-15 | 2013-12-19 | Virginia Commonwealth University | Methods and compositions for controlled and sustained production and delivery of peroxides |
JP5205369B2 (ja) * | 2006-05-22 | 2013-06-05 | アライアンス ファーマシューティカル コーポレイション | 血液代替のため、および他の治療的使用のための、最適化フルオロカーボンエマルジョン |
WO2008070490A2 (en) * | 2006-11-28 | 2008-06-12 | Wisconsin Alumni Research Foundation | Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics |
US8900562B2 (en) * | 2007-01-12 | 2014-12-02 | Wisconsin Alumni Research Foundation | Semi-fluorinated block copolymers for delivery of therapeutic agents |
WO2009102487A2 (en) * | 2008-02-13 | 2009-08-20 | Oxygen Biotherapeutics, Inc. | Gas based wound and tissue therapeutics |
WO2010008594A1 (en) * | 2008-07-18 | 2010-01-21 | Oxygen Biotherapeutics, Inc. | Method of treating traumatic brain injury |
US20100093873A1 (en) * | 2008-10-02 | 2010-04-15 | Goldfischer Sidney L | Methods of improving therapy of perfluorocarbons (PFC) |
EP2373289A4 (en) | 2008-12-08 | 2014-07-02 | Univ Utah Res Found | STABLE PERFLUOROCARBON EMULSION FOR USE AS ARTIFICIAL OXYGEN SUPPORT |
US20100144597A1 (en) * | 2008-12-10 | 2010-06-10 | Ward Kevin R | Novel combinatorial approaches to enhancing oxygen transport to tissues |
CN102395548A (zh) * | 2009-04-15 | 2012-03-28 | 奥斯金生医公司 | 全氟化碳类乳液 |
WO2012003457A1 (en) * | 2010-07-01 | 2012-01-05 | Mtm Research Llc | Anti-fibroblastic fluorochemical emulsion therapies |
US9700523B2 (en) | 2011-10-13 | 2017-07-11 | Nuvox Pharma Llc | Buffered oxygen therapeutic |
US8822549B2 (en) * | 2011-10-13 | 2014-09-02 | Jennifer L. Johnson | Buffered oxygen therapeutic |
WO2017201089A1 (en) | 2016-05-16 | 2017-11-23 | Mtm Research, Llc | Fluorochemical targeted therapies |
US11406722B2 (en) * | 2017-03-16 | 2022-08-09 | The Board Of Regents Of The University Of Texas System | Nanodroplets with improved properties |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4289499A (en) * | 1978-10-13 | 1981-09-15 | Childrens Hospital Medical Center | Selecting perfluorocarbon compounds for synthetic blood |
FR2523956A1 (fr) * | 1982-03-26 | 1983-09-30 | Ugine Kuhlmann | Bis-(perfluoroalkyl)-1,2-ethenes ramifies, leur preparation et leur utilisation comme transporteurs d'oxygene convertisseur electromecanique |
GB8504916D0 (en) * | 1985-02-26 | 1985-03-27 | Isc Chemicals Ltd | Emulsions of perfluorocarbons in aqueous media |
US4927623A (en) * | 1986-01-14 | 1990-05-22 | Alliance Pharmaceutical Corp. | Dissolution of gas in a fluorocarbon liquid |
US4865836A (en) * | 1986-01-14 | 1989-09-12 | Fluoromed Pharmaceutical, Inc. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US5080885A (en) * | 1986-01-14 | 1992-01-14 | Alliance Pharmaceutical Corp. | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport |
US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
US4866096A (en) * | 1987-03-20 | 1989-09-12 | Air Products And Chemicals, Inc. | Stable fluorochemical aqueous emulsions |
US4895876A (en) * | 1987-03-20 | 1990-01-23 | Air Products And Chemicals, Inc. | Concentrated stable fluorochemical aqueous emulsions containing triglycerides |
US5171755A (en) * | 1988-04-29 | 1992-12-15 | Hemagen/Pfc | Emulsions of highly fluorinated organic compounds |
US4993415A (en) * | 1988-08-19 | 1991-02-19 | Alliance Pharmaceutical Corp. | Magnetic resonance imaging with perfluorocarbon hydrides |
DE4019062A1 (de) * | 1989-08-30 | 1991-03-07 | Kali Chemie Ag | Stabilisierung von perfluorcarbonemulsionen und als emulsionsstabilisierende zusaetze verwendbare perfluorierte heterocyclische verbindungen |
FR2679150A1 (fr) * | 1991-07-17 | 1993-01-22 | Atta | Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations. |
US5264220A (en) * | 1991-11-12 | 1993-11-23 | Long David M Jr | Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents |
US5344393A (en) * | 1992-02-28 | 1994-09-06 | Alliance Pharmaceutical Corp. | Use of synthetic oxygen carriers to facilitate oxygen delivery |
DE4211958A1 (de) * | 1992-04-01 | 1993-10-21 | Pharmpur Gmbh | Behandlungsmittel für die Augenheilkunde und seine Verwendung |
US5628930A (en) * | 1992-10-27 | 1997-05-13 | Alliance Pharmaceutical Corp. | Stabilization of fluorocarbon emulsions |
FR2700696B1 (fr) * | 1993-01-28 | 1995-04-07 | Atta | Dispersions, émulsions, microémulsions, gels et compositions à usage biomédical comprenant un composé organique fluoré iodé, utilisables notamment comme agent de contraste. |
US5635538A (en) * | 1993-03-16 | 1997-06-03 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions with reduced pulmonary gas-trapping properties |
US5674913A (en) * | 1994-05-13 | 1997-10-07 | Synthetic Blood International, Inc. | Method for assisting normal breathing in a mammal having a lung disorder |
US5502094A (en) * | 1994-05-20 | 1996-03-26 | Minnesota Mining And Manufacturing Company | Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use |
US5874481A (en) * | 1995-06-07 | 1999-02-23 | Alliance Pharmaceutical Corp. | Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents |
-
1992
- 1992-10-27 US US07/967,700 patent/US5628930A/en not_active Expired - Lifetime
-
1993
- 1993-10-27 JP JP51127394A patent/JP3854630B2/ja not_active Expired - Fee Related
- 1993-10-27 ES ES94901211T patent/ES2095739T4/es not_active Expired - Lifetime
- 1993-10-27 DK DK94901211.6T patent/DK0666736T3/da active
- 1993-10-27 EP EP94901211A patent/EP0666736B1/en not_active Expired - Lifetime
- 1993-10-27 CA CA002146757A patent/CA2146757C/en not_active Expired - Fee Related
- 1993-10-27 WO PCT/US1993/010286 patent/WO1994009625A2/en active IP Right Grant
- 1993-10-27 DE DE69306810T patent/DE69306810T2/de not_active Expired - Lifetime
- 1993-10-27 AT AT94901211T patent/ATE146358T1/de not_active IP Right Cessation
- 1993-10-27 AU AU55878/94A patent/AU678418B2/en not_active Ceased
-
1997
- 1997-02-26 GR GR960403598T patent/GR3022641T3/el unknown
- 1997-05-12 US US08/854,547 patent/US5914352A/en not_active Expired - Fee Related
-
1999
- 1999-03-05 US US09/263,924 patent/US6204296B1/en not_active Expired - Fee Related
-
2001
- 2001-12-03 US US10/007,053 patent/US20020065326A1/en not_active Abandoned
-
2003
- 2003-05-05 US US10/430,198 patent/US20050256211A9/en not_active Abandoned
-
2005
- 2005-12-06 JP JP2005352110A patent/JP2006160742A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE146358T1 (de) | 1997-01-15 |
WO1994009625A2 (en) | 1994-05-11 |
JP2006160742A (ja) | 2006-06-22 |
AU5587894A (en) | 1994-05-24 |
US6204296B1 (en) | 2001-03-20 |
US5628930A (en) | 1997-05-13 |
JPH08502753A (ja) | 1996-03-26 |
CA2146757A1 (en) | 1994-05-11 |
US20050256211A9 (en) | 2005-11-17 |
CA2146757C (en) | 2004-09-21 |
US20040068020A1 (en) | 2004-04-08 |
JP3854630B2 (ja) | 2006-12-06 |
GR3022641T3 (en) | 1997-05-31 |
WO1994009625A3 (en) | 1994-07-21 |
DE69306810T2 (de) | 1997-06-26 |
ES2095739T3 (es) | 1997-02-16 |
US20020065326A1 (en) | 2002-05-30 |
DK0666736T3 (da) | 1996-12-18 |
AU678418B2 (en) | 1997-05-29 |
DE69306810D1 (de) | 1997-01-30 |
US5914352A (en) | 1999-06-22 |
EP0666736A1 (en) | 1995-08-16 |
EP0666736B1 (en) | 1996-12-18 |
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