ES2186484B1 - Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos. - Google Patents
Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos.Info
- Publication number
- ES2186484B1 ES2186484B1 ES200002447A ES200002447A ES2186484B1 ES 2186484 B1 ES2186484 B1 ES 2186484B1 ES 200002447 A ES200002447 A ES 200002447A ES 200002447 A ES200002447 A ES 200002447A ES 2186484 B1 ES2186484 B1 ES 2186484B1
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- tumors
- evil
- cancer drugs
- liposomes encapsulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 229940041181 antineoplastic drug Drugs 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 108010028921 Lipopeptides Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- ZADHKSJXSZBQFB-HHHXNRCGSA-N lipid fragment Chemical compound CC(C)CCCCCCCCCCCC[C@@H](C)CCCCCCCC(C)C ZADHKSJXSZBQFB-HHHXNRCGSA-N 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Liposomas encapsulando fármacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos. Los liposomas están recubiertos por un lipopéptido compuesto por tres subestructuras: un fragmento lipídico, un oligopéptido activo y un oligopéptido espaciador entre los otros dos fragmentos. Aplicable en la administración intravenosa para el tratamiento de tumores malignos.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002447A ES2186484B1 (es) | 2000-10-10 | 2000-10-10 | Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos. |
DE60117583T DE60117583T2 (de) | 2000-10-10 | 2001-10-03 | Liposomen welche antikanzeröse wirkstoffe verkapseln und deren verwendung zur behandlung von malignen tumoren |
AU2001291904A AU2001291904C1 (en) | 2000-10-10 | 2001-10-03 | Liposomes encapsulating anticancer drugs and the use thereof in the treatment of malignant tumors |
PT01972111T PT1325739E (pt) | 2000-10-10 | 2001-10-03 | Lipossomas que encapsulam farmacos anti-cancerigenos e sua utilizacao no tratamento de tumores malignos |
US10/398,627 US7153490B2 (en) | 2000-10-10 | 2001-10-03 | Liposomes encapsulating anticancer drugs and use thereof in the treatment of malignant tumors |
PCT/ES2001/000367 WO2002030397A1 (es) | 2000-10-10 | 2001-10-03 | Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos |
BR0113552-0A BR0113552A (pt) | 2000-10-10 | 2001-10-03 | Lipossomas que encapsulam fármacos anticancerìgenos e uso dos mesmos no tratamento de tumores malignos |
JP2002533840A JP4286535B2 (ja) | 2000-10-10 | 2001-10-03 | 抗癌剤を封入したリポソーム及び悪性腫瘍の治療におけるその使用方法 |
DK01972111T DK1325739T3 (da) | 2000-10-10 | 2001-10-03 | Liposomer, der indkapsler anti-cancerlægemidler og anvendelsen deraf i behandlingen af maligne tumorer |
MXPA03003125A MXPA03003125A (es) | 2000-10-10 | 2001-10-03 | Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos. |
ES01972111T ES2259674T3 (es) | 2000-10-10 | 2001-10-03 | Liposomas de encapsulacion de farmacos anticancerosos y utilizacion de los mismos en el tratamiento de tumores malignos. |
AT01972111T ATE318582T1 (de) | 2000-10-10 | 2001-10-03 | Liposomen welche antikanzeröse wirkstoffe verkapseln und deren verwendung zur behandlung von malignen tumoren |
EP01972111A EP1325739B1 (en) | 2000-10-10 | 2001-10-03 | Liposomes encapsulating anticancer drugs and the use thereof in the treatment of malignant tumors |
AU9190401A AU9190401A (en) | 2000-10-10 | 2001-10-03 | Liposomes encapsulating anticancer drugs and the use thereof in the treatment ofmalignant tumors |
CA2425271A CA2425271C (en) | 2000-10-10 | 2001-10-03 | Liposomes encapsulating anticancerous drugs and use thereof in the treatment of malignant tumours |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200002447A ES2186484B1 (es) | 2000-10-10 | 2000-10-10 | Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2186484A1 ES2186484A1 (es) | 2003-05-01 |
ES2186484B1 true ES2186484B1 (es) | 2004-07-01 |
Family
ID=8495226
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200002447A Expired - Fee Related ES2186484B1 (es) | 2000-10-10 | 2000-10-10 | Liposomas encapsulando farmacos anticancerosos y uso de los mismos en el tratamiento de tumores malignos. |
ES01972111T Expired - Lifetime ES2259674T3 (es) | 2000-10-10 | 2001-10-03 | Liposomas de encapsulacion de farmacos anticancerosos y utilizacion de los mismos en el tratamiento de tumores malignos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01972111T Expired - Lifetime ES2259674T3 (es) | 2000-10-10 | 2001-10-03 | Liposomas de encapsulacion de farmacos anticancerosos y utilizacion de los mismos en el tratamiento de tumores malignos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7153490B2 (es) |
EP (1) | EP1325739B1 (es) |
JP (1) | JP4286535B2 (es) |
AT (1) | ATE318582T1 (es) |
AU (1) | AU9190401A (es) |
BR (1) | BR0113552A (es) |
CA (1) | CA2425271C (es) |
DE (1) | DE60117583T2 (es) |
DK (1) | DK1325739T3 (es) |
ES (2) | ES2186484B1 (es) |
MX (1) | MXPA03003125A (es) |
PT (1) | PT1325739E (es) |
WO (1) | WO2002030397A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
KR20050109958A (ko) * | 2003-03-04 | 2005-11-22 | 가부시키가이샤 소세이 | Gm-95 물질을 함유하는 항종양 효과 증강제, 항종양용조합 제제 및 항종양제 |
WO2005021012A1 (ja) * | 2003-08-29 | 2005-03-10 | Terumo Kabushiki Kaisha | ゲムシタビン封入薬剤担体 |
CN1925871A (zh) * | 2004-01-27 | 2007-03-07 | 南加州大学 | 聚合物结合的抗体癌症治疗剂 |
US8022279B2 (en) | 2004-04-22 | 2011-09-20 | Celator Pharmaceuticals, Inc. | Liposomal formulations of anthracycline agents and cytidine analogs |
ES2293753B1 (es) | 2004-04-28 | 2009-03-16 | Lipotec, S.A. | Uso de peptidos xikvav en preparacion de composiciones cosmeticas para mejorar la firmeza de la piel mediante el aumento de la adhesion celular. |
CN100438855C (zh) * | 2006-01-19 | 2008-12-03 | 浙江大学 | 重酒石酸长春瑞滨脂质体及其冻干粉针与制备方法 |
CN101209243B (zh) * | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种脂质体药物及其制备方法 |
JP4966084B2 (ja) | 2007-04-25 | 2012-07-04 | エスアイアイ・プリンテック株式会社 | インクジェットヘッドの駆動方法、インクジェットヘッドおよびインクジェット記録装置 |
US8067432B2 (en) * | 2008-03-31 | 2011-11-29 | University Of Kentucky Research Foundation | Liposomal, ring-opened camptothecins with prolonged, site-specific delivery of active drug to solid tumors |
WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
CN103083239B (zh) | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
CN107530291A (zh) | 2015-03-03 | 2018-01-02 | 奎尔波特股份有限公司 | 双重负载的脂质体药物制剂 |
CN107530283A (zh) | 2015-03-03 | 2018-01-02 | 奎尔波特股份有限公司 | 组合脂质体药物制剂 |
CN106955271A (zh) * | 2016-01-08 | 2017-07-18 | 佛山英特医药科技有限公司 | 奥沙利铂聚集体及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985000968A1 (en) | 1983-09-06 | 1985-03-14 | Health Research, Inc. | Liposome delivery method for decreasing the toxicity of an antitumor drug |
WO1986004232A1 (en) * | 1985-01-18 | 1986-07-31 | Cooper-Lipotech, Inc. | Liposome composition and method |
US4797285A (en) | 1985-12-06 | 1989-01-10 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Lipsome/anthraquinone drug composition and method |
CA2088975A1 (en) | 1990-08-08 | 1992-02-09 | Anthony H. Huang | Stable doxorubicin/liposome composition |
ES2072223B1 (es) | 1993-11-25 | 1996-03-16 | Lipotec Sa | Liposomas encapsulando doxorubicina. |
US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
-
2000
- 2000-10-10 ES ES200002447A patent/ES2186484B1/es not_active Expired - Fee Related
-
2001
- 2001-10-03 US US10/398,627 patent/US7153490B2/en not_active Expired - Fee Related
- 2001-10-03 JP JP2002533840A patent/JP4286535B2/ja not_active Expired - Fee Related
- 2001-10-03 DE DE60117583T patent/DE60117583T2/de not_active Expired - Lifetime
- 2001-10-03 ES ES01972111T patent/ES2259674T3/es not_active Expired - Lifetime
- 2001-10-03 BR BR0113552-0A patent/BR0113552A/pt not_active IP Right Cessation
- 2001-10-03 WO PCT/ES2001/000367 patent/WO2002030397A1/es active IP Right Grant
- 2001-10-03 DK DK01972111T patent/DK1325739T3/da active
- 2001-10-03 CA CA2425271A patent/CA2425271C/en not_active Expired - Fee Related
- 2001-10-03 EP EP01972111A patent/EP1325739B1/en not_active Expired - Lifetime
- 2001-10-03 AU AU9190401A patent/AU9190401A/xx active Pending
- 2001-10-03 AT AT01972111T patent/ATE318582T1/de active
- 2001-10-03 MX MXPA03003125A patent/MXPA03003125A/es active IP Right Grant
- 2001-10-03 PT PT01972111T patent/PT1325739E/pt unknown
Non-Patent Citations (1)
Title |
---|
GRANDT, D.S. et al.: "Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo", JOURNAL OF CELLULAR PHYSIOLOGY, Vol. 153, nº 3, 1991, páginas 614-625. Todo el documento. * |
Also Published As
Publication number | Publication date |
---|---|
ATE318582T1 (de) | 2006-03-15 |
US7153490B2 (en) | 2006-12-26 |
US20050100590A1 (en) | 2005-05-12 |
EP1325739B1 (en) | 2006-03-01 |
DK1325739T3 (da) | 2006-07-10 |
WO2002030397A9 (es) | 2004-05-13 |
PT1325739E (pt) | 2006-07-31 |
CA2425271C (en) | 2011-04-19 |
EP1325739A1 (en) | 2003-07-09 |
WO2002030397A1 (es) | 2002-04-18 |
JP4286535B2 (ja) | 2009-07-01 |
DE60117583D1 (de) | 2006-04-27 |
AU2001291904B2 (en) | 2006-05-11 |
AU9190401A (en) | 2002-04-22 |
CA2425271A1 (en) | 2003-04-08 |
ES2259674T3 (es) | 2006-10-16 |
MXPA03003125A (es) | 2004-05-04 |
JP2004510811A (ja) | 2004-04-08 |
ES2186484A1 (es) | 2003-05-01 |
BR0113552A (pt) | 2003-07-29 |
DE60117583T2 (de) | 2006-10-05 |
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Legal Events
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