ES2184063T3 - Procedimiento de produccion de preparaciones de clorhidrato de efonidipina. - Google Patents

Procedimiento de produccion de preparaciones de clorhidrato de efonidipina.

Info

Publication number
ES2184063T3
ES2184063T3 ES97907336T ES97907336T ES2184063T3 ES 2184063 T3 ES2184063 T3 ES 2184063T3 ES 97907336 T ES97907336 T ES 97907336T ES 97907336 T ES97907336 T ES 97907336T ES 2184063 T3 ES2184063 T3 ES 2184063T3
Authority
ES
Spain
Prior art keywords
treatment
efonidipine
mixture
production
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97907336T
Other languages
English (en)
Inventor
Misao Miyamoto
Toshihisa Oda
Toyohiko Bunrin
Toshio Okabe
Tetsuyuki Nishiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeria Pharmaceutical Co Ltd
Nissan Chemical Corp
Original Assignee
Zeria Pharmaceutical Co Ltd
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeria Pharmaceutical Co Ltd, Nissan Chemical Corp filed Critical Zeria Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2184063T3 publication Critical patent/ES2184063T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION PUEDE FORMAR UNA DISPERSION SOLIDA AMORFA DE CLORHIDRATO DE EFONIDIPINAQUE TIENE UNA ELEVADA ABSORCION INTESTINAL Y QUE PUEDE OBTENERSE SOMETIENDOSE UNA MEZCLA, QUE CONTIENE CLORHIDRATO DE EFONIDIPINADE FORMULA (I), HIDROXIPROPILMETILCELULOSA ACETATO SUCCINATO Y, OPTATIVAMENTE, UN TERMOESTABILIZADOR, A UNA ETAPA A DE TRATAMIENTO TERMICO A UNA TEMPERATURA DE 85 A 140G C, O TRATAMIENTO MECANOQUIMICO DE 0 A 140G C Y ACTO SEGUIDO A UNA ETAPA B DE TRATAMIENTO DE INMERSION EN UNA SOLUCION QUE CONTIENE AGUA, TRATAMIENTO DE IMPREGNACION CON UNA SOLUCION QUE CONTIENE AGUA O TRATAMIENTO DE CONTACTO CON UN GAS QUE CONTIENE VAPOR DE AGUA; O TRATAR LA MEZCLA ARRIBA MENCIONADA CON UNA CORRIENTE CALIENTE DE 100 A 140G C Y A PRESION ELEVADA. ADEMAS, EN LA ETAPA A ARRIBA MENCIONADA, LA MEZCLA SE SOMETE A CALENTAMIENTO DE ALTA FRECUENCIA, PERMITIENDOLE ASI PROPORCIONAR UNA DISPERSION SOLIDA DE CLORHIDRATO DE EFONIDIPINACON UNA ELEVADA ABSORCION INTESTINAL SIN NECESIDAD DE ACUDIR A LA ETAPA B. ESTE PROCESO ES MUY ADECUADO PARA LA PRODUCCION, YA QUE NO SE EXIGE EL USO DE UN DISOLVENTE ORGANICO.
ES97907336T 1996-03-18 1997-03-17 Procedimiento de produccion de preparaciones de clorhidrato de efonidipina. Expired - Lifetime ES2184063T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8886896 1996-03-18
JP8886996 1996-03-18

Publications (1)

Publication Number Publication Date
ES2184063T3 true ES2184063T3 (es) 2003-04-01

Family

ID=26430207

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97907336T Expired - Lifetime ES2184063T3 (es) 1996-03-18 1997-03-17 Procedimiento de produccion de preparaciones de clorhidrato de efonidipina.

Country Status (11)

Country Link
US (1) US6171599B1 (es)
EP (1) EP0893999B8 (es)
KR (1) KR100457273B1 (es)
AT (1) ATE223722T1 (es)
AU (1) AU1941897A (es)
CA (1) CA2248582C (es)
DE (1) DE69715395T2 (es)
ES (1) ES2184063T3 (es)
PT (1) PT893999E (es)
TW (1) TW487574B (es)
WO (1) WO1997034610A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837903T2 (de) 1997-08-11 2008-02-14 Pfizer Products Inc., Groton Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit
CN1630629B (zh) * 2002-02-28 2010-05-05 日本烟草产业株式会社 酯化合物及其医药用途
JP4832897B2 (ja) * 2003-08-29 2011-12-07 日本たばこ産業株式会社 エステル誘導体及びその医薬用途
US20060030623A1 (en) * 2004-07-16 2006-02-09 Noboru Furukawa Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
CN101068546A (zh) * 2004-10-06 2007-11-07 卫材R&D管理有限公司 医药组合物及其制造方法以及医药组合物中的二氢吡啶类化合物的稳定化方法
US8101774B2 (en) * 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
CA2582767C (en) * 2004-10-25 2011-05-24 Japan Tobacco Inc. Solid formulation with improved solubility and stability and method for producing said formulation
WO2006118210A1 (ja) * 2005-04-28 2006-11-09 Eisai R & D Management Co., Ltd. ジヒドロピリジン系化合物の分解を防止する方法
US8133513B2 (en) 2006-03-23 2012-03-13 Shionogi & Co., Ltd. Solid preparation having improved solubility

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1016063B (zh) * 1986-01-22 1992-04-01 日产化学工业株式会社 二氢吡啶-5-膦酸环亚丙基酯的制备
JP2528706B2 (ja) 1988-05-30 1996-08-28 ゼリア新薬工業株式会社 ジヒドロピリジン化合物の製剤組成物

Also Published As

Publication number Publication date
DE69715395D1 (de) 2002-10-17
CA2248582A1 (en) 1997-09-25
WO1997034610A1 (en) 1997-09-25
ATE223722T1 (de) 2002-09-15
AU1941897A (en) 1997-10-10
EP0893999B1 (en) 2002-09-11
CA2248582C (en) 2005-06-14
DE69715395T2 (de) 2003-05-15
KR20000064632A (ko) 2000-11-06
US6171599B1 (en) 2001-01-09
EP0893999B8 (en) 2003-01-02
KR100457273B1 (ko) 2005-04-08
TW487574B (en) 2002-05-21
PT893999E (pt) 2002-12-31
EP0893999A1 (en) 1999-02-03

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