ES2181889T3 - Proteina antiproliferativa de bacillus thuringiensis var. thuringiensis. - Google Patents
Proteina antiproliferativa de bacillus thuringiensis var. thuringiensis.Info
- Publication number
- ES2181889T3 ES2181889T3 ES96917890T ES96917890T ES2181889T3 ES 2181889 T3 ES2181889 T3 ES 2181889T3 ES 96917890 T ES96917890 T ES 96917890T ES 96917890 T ES96917890 T ES 96917890T ES 2181889 T3 ES2181889 T3 ES 2181889T3
- Authority
- ES
- Spain
- Prior art keywords
- thuringiensis
- protein
- var
- cell
- bacillus thuringiensis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 241000193388 Bacillus thuringiensis Species 0.000 title abstract 2
- 229940097012 bacillus thuringiensis Drugs 0.000 title abstract 2
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 1
- 238000011287 therapeutic dose Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA UNA PROTEINA PURIFICADA Y AISLADA DERIVADA DE BACILLUS THURINGIENSIS, SUBESPECIE THURINGIENSIS, QUE POSEE UN PESO MOLECULAR DE APROXIMADAMENTE 20 KDA EN SDS-PAGE, POSEYENDO DICHA PROTEINA LA SECUENCIA AMINOACIDICA PARCIAL MOSTRADA EN LA SEQ ID NUM. 1, Y EN LA QUE DICHA PROTEINA MUESTRA EFECTOS CITOTOXICOS CONTRA CELULAS TUMORALES. SE PROPORCIONA ASIMISMO UN METODO DE TRATAR UNA CELULA NEOPLASICA QUE COMPRENDE LA ADMINISTRACION DE UNA DOSIS TERAPEUTICA EFICAZ DE UNA COMPOSICION DE LA PRESENTE INVENCION A DICHA CELULA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45463695A | 1995-05-31 | 1995-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2181889T3 true ES2181889T3 (es) | 2003-03-01 |
Family
ID=23805447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96917890T Expired - Lifetime ES2181889T3 (es) | 1995-05-31 | 1996-05-31 | Proteina antiproliferativa de bacillus thuringiensis var. thuringiensis. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5824636A (es) |
| EP (1) | EP0835260B1 (es) |
| JP (1) | JP3786962B2 (es) |
| CN (1) | CN1144816C (es) |
| AU (1) | AU6028196A (es) |
| CA (1) | CA2234794C (es) |
| DE (1) | DE69624570T2 (es) |
| ES (1) | ES2181889T3 (es) |
| RU (1) | RU2178798C2 (es) |
| TW (1) | TW557299B (es) |
| WO (1) | WO1996038477A1 (es) |
| ZA (1) | ZA964359B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011000894A (es) * | 2010-12-17 | 2012-06-18 | Ct De Investigacion Cientifica Y De Educacion Superior De Ensenada B C | Proteinas cry insecticidas de bacilus thuringiensis con actividad anticancerígena. |
-
1996
- 1996-05-29 ZA ZA9604359A patent/ZA964359B/xx unknown
- 1996-05-31 JP JP53671196A patent/JP3786962B2/ja not_active Expired - Fee Related
- 1996-05-31 WO PCT/US1996/008189 patent/WO1996038477A1/en active IP Right Grant
- 1996-05-31 AU AU60281/96A patent/AU6028196A/en not_active Abandoned
- 1996-05-31 ES ES96917890T patent/ES2181889T3/es not_active Expired - Lifetime
- 1996-05-31 CN CNB961960361A patent/CN1144816C/zh not_active Expired - Fee Related
- 1996-05-31 CA CA002234794A patent/CA2234794C/en not_active Expired - Fee Related
- 1996-05-31 DE DE69624570T patent/DE69624570T2/de not_active Expired - Fee Related
- 1996-05-31 RU RU97121930/13A patent/RU2178798C2/ru not_active IP Right Cessation
- 1996-05-31 EP EP96917890A patent/EP0835260B1/en not_active Expired - Lifetime
- 1996-11-04 US US08/743,553 patent/US5824636A/en not_active Expired - Fee Related
- 1996-12-04 TW TW085114980A patent/TW557299B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69624570T2 (de) | 2003-03-20 |
| EP0835260A1 (en) | 1998-04-15 |
| EP0835260B1 (en) | 2002-10-30 |
| EP0835260A4 (en) | 1999-06-02 |
| US5824636A (en) | 1998-10-20 |
| CA2234794A1 (en) | 1996-12-05 |
| CN1144816C (zh) | 2004-04-07 |
| JP3786962B2 (ja) | 2006-06-21 |
| TW557299B (en) | 2003-10-11 |
| AU6028196A (en) | 1996-12-18 |
| MX9709247A (es) | 1998-10-31 |
| WO1996038477A1 (en) | 1996-12-05 |
| CA2234794C (en) | 2008-05-13 |
| ZA964359B (en) | 1998-07-29 |
| CN1192220A (zh) | 1998-09-02 |
| RU2178798C2 (ru) | 2002-01-27 |
| JPH11507025A (ja) | 1999-06-22 |
| DE69624570D1 (en) | 2002-12-05 |
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