ES2180992T3 - Colorantes con funcionalidad triciclica para la mejora del contraste en la formacion optica de imagenes. - Google Patents

Colorantes con funcionalidad triciclica para la mejora del contraste en la formacion optica de imagenes.

Info

Publication number
ES2180992T3
ES2180992T3 ES97924639T ES97924639T ES2180992T3 ES 2180992 T3 ES2180992 T3 ES 2180992T3 ES 97924639 T ES97924639 T ES 97924639T ES 97924639 T ES97924639 T ES 97924639T ES 2180992 T3 ES2180992 T3 ES 2180992T3
Authority
ES
Spain
Prior art keywords
alkyl
alkoxyalkyl
hydroxyalkyl
group
tricycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97924639T
Other languages
English (en)
Inventor
Ella Y Fung
Raghavan Rajagopalan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ES2180992T3 publication Critical patent/ES2180992T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Optical Filters (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION DESCRIBE COLORANTES FUNCIONES CON LA FORMULA GENERAL (1) EN LA CUAL R 1 , R 2 Y R SUP, 5 PUEDEN SER IDENTICOS O DIFERENTES Y SE SELECCIONAN EN EL GRUPO QUE COMPRENDE HIDROGENO, C 1 - C 10 ALQUILO, C 1 - C 10 ALCOXILO, HIDROXILO,L C 1 C 10 HIDROXIALQUILO, C 1 - C 10 ALCOXIALQUILO, C 1 - C 10 ARILO, CARBOXILO, C 1 C 10 CARBOXIALQUILO, HALOGENO, NITRO, C 1 - C SUB, 10 ALCOXICARBONILO, MERCAPTO, C 1 - C 10 ME RCAPTOALQUILO, C 1 - C 10 ALQUITIO, SULFONATO Y -CH 2) M - N(R 6 )(R 7 DONDE R 6 Y R 7 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O C SUB, 1 - C 10 ALQUILO, C 1 - C 10 ACILO, Y R 6 Y R 7 PUEDEN FORMAR CICLOS CON 5, 6 O 7 MIEMBROS QUE PUEDEN OCASIONALMENTE SER SUBSTITUIDOS POR - O -, NR 8 , O - S -; R 3 Y R 4 PUEDEN SER IDENT ICOS O DIFERENTES Y SE SELECCIONAN EN EL GRUPO CONSTITUIDO DE C 10 ALQUILO, C 1 - C 10 HIDROXIALQUILO, C 1 - C 10 ALCOXIALQUILO, C 1 - C 10 ARILO, C 1 - C 10 CARBOXILALQUILO, C 1 - C 10 ALQUILO SULFONATO, MERCAPTO ALQUILO Y - (CH 2 M N(R 6 )(R 7 ; W1 Y W 2 PUEDEN SER IDENTICOS O DIFERENTES Y SE SELECCIONAN DEL GRUPO QUE COMPRENDE - S -, - O -, - SE -, TE -, NR 8 Y C(R SU P,9 Y R 10 ; Y M ES ALREDEDOR DE 0 - 10; R 8 ES HIDROGENO, C 1 - C 10 ALQUILO, C 1 - C SUB, 10 ALCOXI, C 1 - C 10 MERCAPTOALQUILO, HIDR OXILO, C 1 - C 10 HIDROXIALQUILO, C 1 - C 10 ALCOXIALQUILO, C 1 - C 10 ARILO, C SUB, 1 - C 10 CARBOXIALQUILO, C 1 - C 10 A LCOXIALQUILO, C 1 - C 10 CARBOXIALQUILO, C 1 - C 10 ALCOXICARBONILO, C 1 - C 10 ALQUITIO, Y - (CH 2 M N(R 6 )(R 7 ; R SUP, 9 Y R 10 SON INDEPENDIENTEMENTE HIDROGENO, C 1 - C 10 ALQUILO, C 1 - C 10 ALCOXILO, C 1 - C 10 HIDROXIALQUILO, C 1 - C 10 ALCOXIALQUILO, C 1 - C 10 CARBOXIALQUILO, C 1 - C 10 ALCOXYCARBONILO, Y - (CH 2 M - N(R 6 )(R 7 ); Y A SE SELECCIONA DEL GRUPO QUE COMPRENDE - (CH 2 ) M - C(R 9 )(R 10), - (CH 2 M - N( R 6 )(R 7 ), - O -, - S - O - NR 8 .
ES97924639T 1996-05-13 1997-05-09 Colorantes con funcionalidad triciclica para la mejora del contraste en la formacion optica de imagenes. Expired - Lifetime ES2180992T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/645,376 US5709845A (en) 1996-05-13 1996-05-13 Tricyclic functional dyes for contrast enhancement in optical imaging

Publications (1)

Publication Number Publication Date
ES2180992T3 true ES2180992T3 (es) 2003-02-16

Family

ID=24588768

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97924639T Expired - Lifetime ES2180992T3 (es) 1996-05-13 1997-05-09 Colorantes con funcionalidad triciclica para la mejora del contraste en la formacion optica de imagenes.

Country Status (8)

Country Link
US (1) US5709845A (es)
EP (1) EP0946203B1 (es)
JP (1) JP2000511521A (es)
AT (1) ATE220925T1 (es)
CA (1) CA2254905C (es)
DE (1) DE69714287T2 (es)
ES (1) ES2180992T3 (es)
WO (1) WO1997042976A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7221398A (en) * 1997-04-29 1998-11-24 Nycomed Imaging As Method of demarcating tissue
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
CO5261573A1 (es) 1999-11-19 2003-03-31 Novartis Ag Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion
US6939532B2 (en) 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US7198778B2 (en) 2000-01-18 2007-04-03 Mallinckrodt Inc. Tumor-targeted optical contrast agents
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6180086B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Hydrophilic cyanine dyes
US6180087B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US20040173051A1 (en) * 2003-03-05 2004-09-09 Sinka Aaron Alexander Breather system for a housing containing a lubricant sump
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3855210A (en) * 1969-02-03 1974-12-17 Itek Corp Improved bis(hydroxyalkyl) styryl dye compounds and photosensitive media containing such compounds
US3655392A (en) * 1969-06-04 1972-04-11 Eastman Kodak Co Photographic silver halide emulsion sensitized with a methine dye
JPH08509260A (ja) * 1993-04-20 1996-10-01 マリンクロット・メディカル・インコーポレイテッド 電圧感受性染料の安定化
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung

Also Published As

Publication number Publication date
CA2254905A1 (en) 1997-11-20
JP2000511521A (ja) 2000-09-05
EP0946203A4 (en) 2000-03-29
EP0946203B1 (en) 2002-07-24
CA2254905C (en) 2003-01-28
US5709845A (en) 1998-01-20
DE69714287D1 (de) 2002-08-29
EP0946203A1 (en) 1999-10-06
WO1997042976A1 (en) 1997-11-20
DE69714287T2 (de) 2003-03-06
ATE220925T1 (de) 2002-08-15

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