ES2179832T3 - Formas de administracion orales con contenido en flupirtina solida, con liberacion controlada del principio activo. - Google Patents

Formas de administracion orales con contenido en flupirtina solida, con liberacion controlada del principio activo.

Info

Publication number
ES2179832T3
ES2179832T3 ES94103292T ES94103292T ES2179832T3 ES 2179832 T3 ES2179832 T3 ES 2179832T3 ES 94103292 T ES94103292 T ES 94103292T ES 94103292 T ES94103292 T ES 94103292T ES 2179832 T3 ES2179832 T3 ES 2179832T3
Authority
ES
Spain
Prior art keywords
flupirtine
controlled release
flupirtina
solida
content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94103292T
Other languages
English (en)
Inventor
Joachim Dr Goede
Helmut Dr Hettche
Helmut Dr Momberger
Jurgen Prof Dr Engel
Michael Dr Lobisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva GmbH
Original Assignee
AWD Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AWD Pharma GmbH and Co KG filed Critical AWD Pharma GmbH and Co KG
Application granted granted Critical
Publication of ES2179832T3 publication Critical patent/ES2179832T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PREPARACIONES DE MEDICAMENTOS QUE CONTIENEN FLUPIRTINA CON SUMINISTRO DE SUSTANCIA ACTIVA CONTROLADO BAJO LA UTILIZACION DE UN COMPONENTE DE RETARDO, DONDE APARECE UNA PORCION EN PESO DE FLUPIRTINA (CON REFERENCIA A LA BASE) DE 0,001 HASTA 20 PARTES DE COMPONENTE DE RETARDO Y LA FLUPIRTINA PUEDE ESTAR PRESENTE TAMBIEN EN FORMA DE SUS SALES TOLERABLES FISIOLOGICAMENTE Y LA VELOCIDAD DE LIBERACION DE LA FLUPIRTINA SE ENCUENTRA ENTRE 5 Y 300 MG POR HORA, EVENTUALMENTE BAJO LA ADICION DE OTRA PORCION DE LIBERACION RAPIDA DE FLUPIRTINA O DE UNA DE SUS SALES.
ES94103292T 1993-03-18 1994-03-04 Formas de administracion orales con contenido en flupirtina solida, con liberacion controlada del principio activo. Expired - Lifetime ES2179832T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4308572 1993-03-18
DE4319649A DE4319649A1 (de) 1993-03-18 1993-06-14 Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe

Publications (1)

Publication Number Publication Date
ES2179832T3 true ES2179832T3 (es) 2003-02-01

Family

ID=25924047

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94103292T Expired - Lifetime ES2179832T3 (es) 1993-03-18 1994-03-04 Formas de administracion orales con contenido en flupirtina solida, con liberacion controlada del principio activo.

Country Status (9)

Country Link
US (1) US6667058B1 (es)
EP (1) EP0615754B1 (es)
JP (1) JP3844517B2 (es)
AT (1) ATE220321T1 (es)
BR (1) BR9401199A (es)
DE (2) DE4319649A1 (es)
DK (1) DK0615754T3 (es)
ES (1) ES2179832T3 (es)
PT (1) PT615754E (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4443175A1 (de) * 1994-12-05 1996-06-13 Jenapharm Gmbh Neue pulsatile Arzneiform
DE10224086A1 (de) * 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10327674A1 (de) * 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
DE10328260A1 (de) * 2003-06-23 2005-01-27 Schmidt, K.-G., Dr. med. Flupirtine-Präparat
EP1688141A1 (en) 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
DE102005054610B4 (de) * 2005-11-08 2010-06-10 Awd.Pharma Gmbh & Co. Kg Flupirtin enthaltende Arzneimittelzubereitung mit kontrollierter Wirkstofffreisetzung
BRPI0709606B8 (pt) 2006-03-16 2021-05-25 Tris Pharma Inc suspensão líquida administrável oralmente com características de liberação modificada
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
WO2009152142A1 (en) 2008-06-09 2009-12-17 Awd. Pharma Gmbh & Co. Kg Sulfonate salts of flupirtine
EP2346826A2 (en) 2008-06-09 2011-07-27 AWD.pharma GmbH & Co.KG Carboxylic acid salts of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine
DE102010030053A1 (de) 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
US8287903B2 (en) 2011-02-15 2012-10-16 Tris Pharma Inc Orally effective methylphenidate extended release powder and aqueous suspension product
CN102764257B (zh) * 2011-10-21 2013-09-25 四川百利药业有限责任公司 一种马来酸氟吡汀缓释片剂
MX2014010460A (es) * 2012-03-02 2014-10-13 Meda Pharma Gmbh & Co Kg Formulaciones farmaceuticas que contienen flupirtina.
AU2013302657B2 (en) 2012-08-15 2018-08-09 Tris Pharma, Inc. Methylphenidate extended release chewable tablet
CN104083335B (zh) * 2013-07-31 2015-11-11 成都苑东药业有限公司 一种马来酸氟吡汀胶囊组合物及其制备方法
US11590228B1 (en) 2015-09-08 2023-02-28 Tris Pharma, Inc Extended release amphetamine compositions
US11590081B1 (en) 2017-09-24 2023-02-28 Tris Pharma, Inc Extended release amphetamine tablets
US11918689B1 (en) 2020-07-28 2024-03-05 Tris Pharma Inc Liquid clonidine extended release composition
WO2024163966A1 (en) 2023-02-03 2024-08-08 Tris Pharma, Inc. Low sodium oxybate once nightly composition

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896108A (en) * 1974-05-10 1975-07-22 Hercules Inc Carboxyalkyl modified ethyl cellulose
HU187215B (en) * 1983-01-26 1985-11-28 Egyt Gyogyszervegyeszeti Gyar Method for producing pharmaceutical product of high actor content and prolonged effect
DE3665538D1 (en) * 1985-01-23 1989-10-19 Asta Pharma Ag Synergistic combination of flupirtin and non-steroidal anti-phlogistics
ATE43789T1 (de) * 1985-02-23 1989-06-15 Asta Pharma Ag Kombination von flupirtin und anticholinergisch wirkenden spasmolytika.
FI855016A (fi) * 1985-06-28 1986-12-29 Degussa Synergistisk kombination av flupirtin och 4-acetamido-fenol.
FR2585246A1 (fr) * 1985-07-26 1987-01-30 Cortial Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
GB8519310D0 (en) * 1985-07-31 1985-09-04 Zyma Sa Granular active substances
US5238686A (en) * 1986-03-27 1993-08-24 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
US4959219A (en) * 1988-08-15 1990-09-25 Fisons Corporation Coating barriers comprising ethyl cellulose
US5229131A (en) * 1990-02-05 1993-07-20 University Of Michigan Pulsatile drug delivery system
IN172468B (es) * 1990-07-14 1993-08-14 Asta Medica Ag
ATE160696T1 (de) * 1992-03-11 1997-12-15 Asta Medica Ag Tabletten, granulate und pellets mit hohem gehalt an wirkstoffen für hochkonzentrierte, feste darreichungsformen

Also Published As

Publication number Publication date
US6667058B1 (en) 2003-12-23
ATE220321T1 (de) 2002-07-15
DE4319649A1 (de) 1994-09-22
BR9401199A (pt) 1994-10-18
DE59410151D1 (de) 2002-08-14
JP3844517B2 (ja) 2006-11-15
EP0615754A1 (de) 1994-09-21
PT615754E (pt) 2002-11-29
EP0615754B1 (de) 2002-07-10
DK0615754T3 (da) 2002-10-28
JPH06298647A (ja) 1994-10-25

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