ES2178741T3 - Derivados farmaceuticos de piridina, procedimientos para su preparacion y productos intermediarios apropiados. - Google Patents

Derivados farmaceuticos de piridina, procedimientos para su preparacion y productos intermediarios apropiados.

Info

Publication number
ES2178741T3
ES2178741T3 ES97309947T ES97309947T ES2178741T3 ES 2178741 T3 ES2178741 T3 ES 2178741T3 ES 97309947 T ES97309947 T ES 97309947T ES 97309947 T ES97309947 T ES 97309947T ES 2178741 T3 ES2178741 T3 ES 2178741T3
Authority
ES
Spain
Prior art keywords
protected
unprotected
piridine
procedures
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97309947T
Other languages
English (en)
Inventor
Tatsuzo Ukita
Masakatsu Sugahara
Katsuo Ikezawa
Hideo Kikkawa
Kazuaki Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2178741T3 publication Critical patent/ES2178741T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Seasonings (AREA)
  • Press Drives And Press Lines (AREA)

Abstract

UN DERIVADO DE LA PIRIDINA DE FORMULA (I): DONDE A ES UN GRUPO DE LAS FORMULAS SIGUIENTES: R{SUP,1} Y R{SUP,2} SON CADA UNO H, OH PROTEGIDO O NO PROTEGIDO, R{SUP,31}, R{SUP,41} Y R{SUP,42} SON HIDROXIMETILO PROTEGIDO O NO PROTEGIDO, R{SUP,32} ES H, ALQUILO DE CADENA CORTA, O HIDROXIMETILO PROTEGIDO O NO PROTEGIDO, R{SUP,33} ES ALQUILO DE CADENA CORTA SUSTITUIDO O NO SUSTITUIDO, Y LA LINEA DISCONTINUA INDICA LA PRESENCIA O AUSENCIA DE UN DOBLE ENLACE, R{SUP,5} Y R{SUP,6} SON H, O AMINO PROTEGIDO O NO PROTEGIDO, O AMBOS SE COMBINAN CON EL NITROGENO ADYACENTE PARA FORMAR UN HETEROCICLO SUSTITUIDO O NO SUSTITUIDO, O UNA DE SUS SALES ACEPTABLE FARMACEUTICAMENTE, MUESTRA EXCELENTE ACTIVIDAD INHIBIDORA DE LA BRONCOCONSTRICCION Y/O ACTIVIDAD ANTIINFLAMATORIA DE LAS VIAS RESPIRATORIAS, Y SON UTILES EN LA PROFILAXIS O TRATAMIENTO DEL ASMA.
ES97309947T 1996-12-13 1997-12-10 Derivados farmaceuticos de piridina, procedimientos para su preparacion y productos intermediarios apropiados. Expired - Lifetime ES2178741T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33335796 1996-12-13

Publications (1)

Publication Number Publication Date
ES2178741T3 true ES2178741T3 (es) 2003-01-01

Family

ID=18265214

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97309947T Expired - Lifetime ES2178741T3 (es) 1996-12-13 1997-12-10 Derivados farmaceuticos de piridina, procedimientos para su preparacion y productos intermediarios apropiados.

Country Status (14)

Country Link
US (1) US5965730A (es)
EP (1) EP0848000B1 (es)
KR (1) KR100416833B1 (es)
CN (1) CN1127498C (es)
AT (1) ATE219075T1 (es)
CA (1) CA2224635C (es)
DE (1) DE69713255T2 (es)
DK (1) DK0848000T3 (es)
ES (1) ES2178741T3 (es)
HK (1) HK1012505A1 (es)
ID (1) ID19155A (es)
PT (1) PT848000E (es)
SG (1) SG53130A1 (es)
TW (1) TW429257B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1302677B1 (it) 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
ID30057A (id) * 1999-02-18 2001-11-01 Hoffmann La Roche Turunan fenilalaninol
DE60043318D1 (de) 1999-08-21 2010-01-14 Nycomed Gmbh Synergistische kombination von pumafentrine und salmeterol
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
AR029289A1 (es) * 2000-07-05 2003-06-18 Ishihara Sangyo Kaisha Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo
US20040146561A1 (en) * 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
CN1537018A (zh) * 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
US20050043315A1 (en) * 2002-01-02 2005-02-24 Hideo Tsutsumi Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
KR20050115331A (ko) 2003-04-01 2005-12-07 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 불임증 포스포디에스터라제의 억제제
JP4794446B2 (ja) 2003-09-23 2011-10-19 メルク・シャープ・エンド・ドーム・コーポレイション イソキノリン系カリウムチャンネル阻害薬
TWI339578B (en) * 2004-10-29 2011-04-01 Mitsubishi Tanabe Pharma Corp Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions
EP1941881B1 (en) * 2005-10-05 2014-08-13 Mitsubishi Tanabe Pharma Corporation Naphthalene derivatives for the treatment of dermatitis and psoriasis
WO2007100880A1 (en) * 2006-02-28 2007-09-07 Amgen Inc. Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
CN102171214B (zh) 2008-08-06 2015-06-24 生物马林药物股份有限公司 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
CA2787844C (en) 2010-02-03 2019-08-27 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly(adp-ribose) polymerase (parp) for use in treatment of diseases associated with a pten deficiency
HUE030794T2 (en) 2010-02-08 2017-06-28 Medivation Technologies Inc Synthesis Processes of Dihydro-Pyrido-Phthalazinone Derivatives
RU2438672C1 (ru) * 2010-04-30 2012-01-10 Общество с ограниченной ответственностью "Клевер Фарм" Агент, проявляющий свойства активатора когнитивных функций (варианты)
AR083502A1 (es) 2010-10-21 2013-02-27 Biomarin Pharm Inc Sal tosilada de (8s,9r)-5-fluoro-8-(4-fluorofenil)-9-(1-metil-1h-1,2,4-triazol-5-il)-8,9-dihidro-2h-pirido[4,3,2-de]ftalazin-3(7h)-ona cristalina
US10662390B2 (en) * 2015-09-02 2020-05-26 Basf Se Lubricant composition
CN108658937A (zh) * 2017-03-28 2018-10-16 中国海洋大学 一种双环生物碱类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027055D0 (en) * 1990-12-13 1991-02-06 Sandoz Ltd Organic compounds
JP3042156B2 (ja) * 1992-02-20 2000-05-15 田辺製薬株式会社 ナフタレン誘導体、その製法及びその合成中間体
GB9322828D0 (en) * 1993-11-05 1993-12-22 Sandoz Ltd Organic compounds
IL118469A (en) * 1995-06-15 2000-08-13 Tanabe Seiyaku Co Naphthalene derivatives their preparation and intermediates thereof

Also Published As

Publication number Publication date
ATE219075T1 (de) 2002-06-15
KR100416833B1 (ko) 2004-05-24
DE69713255D1 (de) 2002-07-18
CN1127498C (zh) 2003-11-12
SG53130A1 (en) 1998-09-28
CA2224635A1 (en) 1998-06-13
MX9710182A (es) 1998-10-31
EP0848000A1 (en) 1998-06-17
CA2224635C (en) 2006-01-31
PT848000E (pt) 2002-09-30
DK0848000T3 (da) 2002-09-30
HK1012505A1 (en) 1999-08-06
KR19980064040A (ko) 1998-10-07
CN1184813A (zh) 1998-06-17
TW429257B (en) 2001-04-11
EP0848000B1 (en) 2002-06-12
DE69713255T2 (de) 2002-11-07
ID19155A (id) 1998-06-18
US5965730A (en) 1999-10-12

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