MX9710182A - Derivados de piridina, procedimiento para preparar los mismos y compuesto intermediario para los mismos. - Google Patents

Derivados de piridina, procedimiento para preparar los mismos y compuesto intermediario para los mismos.

Info

Publication number
MX9710182A
MX9710182A MX9710182A MX9710182A MX9710182A MX 9710182 A MX9710182 A MX 9710182A MX 9710182 A MX9710182 A MX 9710182A MX 9710182 A MX9710182 A MX 9710182A MX 9710182 A MX9710182 A MX 9710182A
Authority
MX
Mexico
Prior art keywords
group
protected
unprotected
same
hydrooxymethyl
Prior art date
Application number
MX9710182A
Other languages
English (en)
Other versions
MXPA97010182A (es
Inventor
Tatsuzo Ukita
Masakatsu Sugahara
Katsuo Ikezawa
Hideo Kikkawa
Kazuaki Naito
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of MX9710182A publication Critical patent/MX9710182A/es
Publication of MXPA97010182A publication Critical patent/MXPA97010182A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Press Drives And Press Lines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un derivado de piridina de la formula (I): en donde A es un grupo de las siguientes formulas: (R1 y R2 son cada uno, H, u OH protegido o no protegido, R31, R41 y R42 son hidroximetilo protegido o no protegido, R32 es H, alquilo interior, o hidroximetilo protegido o no protegido, R33 es alquilo inferior substituido o no substituido, y las líneas punteadas significan la presencia o ausencia de una doble ligadura), R5 y R6 son H, o amina protegida o no protegida, o ambos se combinan junto con el nitrogeno adyacente para formar un heterociclo substituido o no substituido, o una sal farmacéuticamente aceptable de los mismos; estos compuestos muestran excelente actividad inhibidora de broncoconstriccion y/o actividad antiinflamatoria de las vías respiratorias, y es util en la profilaxis o tratamiento de asma.
MXPA/A/1997/010182A 1996-12-13 1997-12-15 Derivados de piridina, procedimiento para preparar los mismos y compuesto intermediario para los mismos MXPA97010182A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP333357/1996 1996-12-13
JP8-333357 1996-12-13
JP33335796 1996-12-13

Publications (2)

Publication Number Publication Date
MX9710182A true MX9710182A (es) 1998-10-31
MXPA97010182A MXPA97010182A (es) 1999-01-11

Family

ID=

Also Published As

Publication number Publication date
KR100416833B1 (ko) 2004-05-24
DE69713255D1 (de) 2002-07-18
EP0848000B1 (en) 2002-06-12
HK1012505A1 (en) 1999-08-06
DE69713255T2 (de) 2002-11-07
SG53130A1 (en) 1998-09-28
US5965730A (en) 1999-10-12
ID19155A (id) 1998-06-18
ES2178741T3 (es) 2003-01-01
DK0848000T3 (da) 2002-09-30
CA2224635A1 (en) 1998-06-13
TW429257B (en) 2001-04-11
PT848000E (pt) 2002-09-30
CN1127498C (zh) 2003-11-12
EP0848000A1 (en) 1998-06-17
ATE219075T1 (de) 2002-06-15
CA2224635C (en) 2006-01-31
CN1184813A (zh) 1998-06-17
KR19980064040A (ko) 1998-10-07

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