ES2178487T3 - Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos. - Google Patents
Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos.Info
- Publication number
- ES2178487T3 ES2178487T3 ES99954071T ES99954071T ES2178487T3 ES 2178487 T3 ES2178487 T3 ES 2178487T3 ES 99954071 T ES99954071 T ES 99954071T ES 99954071 T ES99954071 T ES 99954071T ES 2178487 T3 ES2178487 T3 ES 2178487T3
- Authority
- ES
- Spain
- Prior art keywords
- perfusion
- range
- conservation
- organ transplantation
- reperfusion solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Solución de perfusión y/o de conservación y/o de la reperfusión en el momento del transplante de órganos, en particular del órgano cardíaco, caracterizada porque contiene los elementos siguientes: K+ a razón de alrededor de 4 a 7 mM, en particular alrededor de 4 mM Ca2+ a razón de alrededor de 0,2 a 0,3 mM, en particular alrededor de 0,25 mM Mg2+ a razón de alrededor de 13 a 16 mM, en particular alrededor de 13 mM glutamato a razón de alrededor de 18 a 22 mM, en particular alrededor de 20 mM arginina a razón de alrededor de 2 a 4 mM, en particular alrededor de 3 mM adenosina a razón de alrededor de 0,5 a 1 mM, en particular alrededor de 0,5 mM
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9814132A FR2785501B1 (fr) | 1998-11-10 | 1998-11-10 | Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2178487T3 true ES2178487T3 (es) | 2002-12-16 |
Family
ID=9532576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99954071T Expired - Lifetime ES2178487T3 (es) | 1998-11-10 | 1999-11-05 | Solucion de perfusion y/o de conservacion y/o de reperfusion en el transplante de organos. |
Country Status (7)
Country | Link |
---|---|
US (1) | US6524785B1 (es) |
EP (1) | EP1047299B1 (es) |
AT (1) | ATE219326T1 (es) |
DE (1) | DE69901877T2 (es) |
ES (1) | ES2178487T3 (es) |
FR (1) | FR2785501B1 (es) |
WO (1) | WO2000027189A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409846B2 (en) | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
US20040170950A1 (en) * | 2002-09-12 | 2004-09-02 | Prien Samuel D. | Organ preservation apparatus and methods |
EP1493806A1 (en) * | 2003-07-02 | 2005-01-05 | Chr. Hansen A/S | Use of compounds involved in biosynthesis of nucleic acids as cryoprotective agents |
US9289003B2 (en) * | 2003-07-02 | 2016-03-22 | Chr. Hansen A/S | Use of compounds involved in biosynthesis of nucleic acids as cryoprotective agents |
CN1901795B (zh) | 2003-10-22 | 2014-03-26 | 弗雷德哈钦森癌症研究中心 | 用于在细胞,组织,器官,和有机体中诱导停滞的方法,组合物和装置 |
US20050136125A1 (en) * | 2003-10-22 | 2005-06-23 | Roth Mark B. | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
US20050170019A1 (en) * | 2003-10-22 | 2005-08-04 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells |
US20050142121A1 (en) * | 2003-12-24 | 2005-06-30 | Gold Joseph D. | System for improving acceptance of tissue grafts made from embryonic stem cells |
US20050153271A1 (en) * | 2004-01-13 | 2005-07-14 | Wenrich Marshall S. | Organ preservation apparatus and methods |
NZ614472A (en) | 2004-10-07 | 2015-03-27 | Transmedics Inc | Systems and methods for ex-vivo organ care |
US9301519B2 (en) * | 2004-10-07 | 2016-04-05 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
AU2006236150A1 (en) * | 2005-04-20 | 2006-10-26 | Fred Hutchinson Cancer Research Center | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
US20070208041A1 (en) * | 2005-10-13 | 2007-09-06 | Stamler Jonathan S | Compositions for the treatment and prevention of heart disease and methods of using same |
IL301141A (en) * | 2006-04-19 | 2023-05-01 | Transmedics Inc | Systems and methods for extracorporeal organ treatment |
US20080145919A1 (en) * | 2006-12-18 | 2008-06-19 | Franklin Thomas D | Portable organ and tissue preservation apparatus, kit and methods |
CN105123670B (zh) | 2007-02-17 | 2018-12-14 | 哈佛学院董事会 | 用于进行组织保存的组合物以及方法 |
US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
US9814230B2 (en) * | 2008-01-31 | 2017-11-14 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
CA2715634A1 (en) | 2008-02-15 | 2009-08-27 | President And Fellows Of Harvard College | Blood substitute solution |
US20090263780A1 (en) * | 2008-04-17 | 2009-10-22 | Yanming Wang | Organ preservation fluid |
US20130323708A1 (en) | 2009-07-01 | 2013-12-05 | Massachusetts Institute Of Technology | Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
WO2011140241A2 (en) * | 2010-05-04 | 2011-11-10 | The General Hospital Corporation | Methods and compositions for preserving tissues and organs |
US20130011823A1 (en) | 2011-04-14 | 2013-01-10 | Hassanein Waleed H | Organ care solution for ex-vivo machine perfusion of donor lungs |
US9119393B2 (en) * | 2012-07-10 | 2015-09-01 | Lifeline Scientific, Inc. | Organ transporter with tilt and/or shock sensing |
US10918102B2 (en) | 2014-03-13 | 2021-02-16 | The General Hospital Corporation | Devices and methods to improve and assess viability of human livers |
US10433539B2 (en) | 2014-04-10 | 2019-10-08 | Tevosol, Inc. | Composition and solution with controlled calcium ion level, and related method and use for reperfusion |
BR112016023394B1 (pt) | 2014-04-10 | 2021-09-21 | Darren Freed | Composição cardioplégica e seu uso |
CA3185937A1 (en) | 2014-06-02 | 2015-12-10 | Transmedics, Inc. | Ex vivo organ care system |
CN107105640B (zh) * | 2014-10-24 | 2021-10-12 | 体沃索股份有限公司 | 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途 |
BR112017010520B1 (pt) | 2014-12-12 | 2022-08-30 | Tevosol, Inc | Aparelho e método para perfusão de órgãos |
US10874098B2 (en) | 2015-04-03 | 2020-12-29 | Tx Innovations B.V. | Organ preservation composition |
CN107949419B (zh) | 2015-09-09 | 2021-03-05 | 特兰斯迈迪茨公司 | 离体器官护理系统用的主动脉插管 |
CN111937861B (zh) * | 2020-08-17 | 2021-10-26 | 南昌大学第二附属医院 | 一种七氟烷缺血再灌注装置及使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4920044A (en) * | 1988-11-08 | 1990-04-24 | The Cleveland Clinic Foundation | Intracellular flush solution for preserving organs |
US5290766A (en) * | 1991-02-18 | 1994-03-01 | The National Heart Foundation Of New Zealand | Cardioplegic compositions |
US5407793A (en) * | 1991-10-18 | 1995-04-18 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | An aqueous heart preservation and cardioplegia solution |
FR2695827B1 (fr) * | 1992-09-18 | 1995-07-28 | Pasteur Merieux Serums Vacc | Solution de perfusion, de conservation et de reperfusion d'organes. |
-
1998
- 1998-11-10 FR FR9814132A patent/FR2785501B1/fr not_active Expired - Fee Related
-
1999
- 1999-11-05 EP EP99954071A patent/EP1047299B1/fr not_active Expired - Lifetime
- 1999-11-05 US US09/582,996 patent/US6524785B1/en not_active Expired - Fee Related
- 1999-11-05 ES ES99954071T patent/ES2178487T3/es not_active Expired - Lifetime
- 1999-11-05 WO PCT/FR1999/002711 patent/WO2000027189A1/fr active IP Right Grant
- 1999-11-05 DE DE69901877T patent/DE69901877T2/de not_active Expired - Lifetime
- 1999-11-05 AT AT99954071T patent/ATE219326T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2785501A1 (fr) | 2000-05-12 |
FR2785501B1 (fr) | 2001-01-05 |
EP1047299B1 (fr) | 2002-06-19 |
US6524785B1 (en) | 2003-02-25 |
ATE219326T1 (de) | 2002-07-15 |
EP1047299A1 (fr) | 2000-11-02 |
DE69901877T2 (de) | 2003-01-23 |
WO2000027189A1 (fr) | 2000-05-18 |
DE69901877D1 (de) | 2002-07-25 |
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