ES2178121T3 - Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica. - Google Patents
Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica.Info
- Publication number
- ES2178121T3 ES2178121T3 ES98400387T ES98400387T ES2178121T3 ES 2178121 T3 ES2178121 T3 ES 2178121T3 ES 98400387 T ES98400387 T ES 98400387T ES 98400387 T ES98400387 T ES 98400387T ES 2178121 T3 ES2178121 T3 ES 2178121T3
- Authority
- ES
- Spain
- Prior art keywords
- derivative
- phenyl
- acetate
- procedure
- manufacturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PRESENTA UN DERIVADO 2 - FENIL - 2 - (2 - PIPERIDINILIDENO) ACETATO DE FORMULA (1) ADECUADO PARA SER UTILIZADO COMO MATERIA PRIMA DE UN DERIVADO 2 - FENIL - 2 - (2 - PIPERIDINIL) ACETATO DE FORMULA (3) Y UN PROCESO DE PRODUCCION DEL MISMO. SE PRESENTA TAMBIEN UN PROCESO DE PRODUCCION DE UN DERIVADO OPTICAMENTE ACTIVO 2 - FENIL - 2 - (2 - PIPERIDINIL) ACETATO QUE ES UN INTERMEDIARIO PRINCIPAL DE UN ANTIDEPRESIVO. EL DERIVADO 2 FENIL - 2 - (2 - PIPERIDINILIDENO) ACETATO SE PRODUCE MEDIANTE LA CICLACION DE UN DERIVADO 7 - (N-SUSTITUIDO AMINO) - 3 - OXO 2 - HEPTANOATO DE FORMULA (2). EL DERIVADO OPTICAMENTE ACTIVO 2 - FENIL - 2 - (2 - PIPERIDINIL) ACETATO SE PRODUCE MEDIANTE HIDROGENACION ASIMETRICA DEL DERIVADO 2 - FENIL - 2 - (2 PIPERIDINILIDENO) ACETATO EN PRESENCIA DE UN COMPLEJO DE UN METAL DE TRANSICION DEL GRUPO VIII O DE UN ACIDO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP09072570A JP3088328B2 (ja) | 1997-02-19 | 1997-02-19 | 光学活性2−フェニル−2−(2’−ピペリジニル) 酢酸エステル誘導体の製造方法 |
JP09117358A JP3088334B2 (ja) | 1997-04-02 | 1997-04-02 | 2−フェニル−2−(2’−ピペリジニリデン)酢酸 エステル誘導体およびその誘導体の製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2178121T3 true ES2178121T3 (es) | 2002-12-16 |
Family
ID=26413698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98400387T Expired - Lifetime ES2178121T3 (es) | 1997-02-19 | 1998-02-18 | Derivado de 2-fenil-2-(2-piperidiniliden) acetato y un procedimiento para fabricar el mismo, y procedimiento para fabricar un derivado de 2-fenil-2-(2-piperidinil) acetato opticamente activo para la hidrogenacion asimetrica. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5859249A (es) |
EP (1) | EP0860432B1 (es) |
CA (1) | CA2211934C (es) |
DE (1) | DE69805676T2 (es) |
ES (1) | ES2178121T3 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6025502A (en) * | 1999-03-19 | 2000-02-15 | The Trustees Of The University Of Pennsylvania | Enantopselective synthesis of methyl phenidate |
US20030170181A1 (en) * | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
US6340476B1 (en) | 1999-04-06 | 2002-01-22 | Armaquest, Inc. | Pharmaceutical dosage form for pulsatile delivery of methylphenidate |
EP1386901B1 (en) * | 2002-07-30 | 2015-07-01 | Takasago International Corporation | Method for producing an optically active beta-amino acid |
JP4040602B2 (ja) * | 2004-05-14 | 2008-01-30 | Necエレクトロニクス株式会社 | 半導体装置 |
JP5271540B2 (ja) | 2005-01-20 | 2013-08-21 | インスティチュート フォー モレキュラー メディスン インコーポレイテッド | メチルフェニデート誘導体を含む治療剤及び医薬組成物 |
US20060183773A1 (en) * | 2005-01-20 | 2006-08-17 | David Bar-Or | Uses of methylphenidate derivatives |
WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
CN115322141B (zh) * | 2022-09-01 | 2024-04-16 | 凯特立斯(深圳)科技有限公司 | 一种不对称氢化制备手性哌甲酯类化合物的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2507631A (en) * | 1944-01-19 | 1950-05-16 | Ciba Pharm Prod Inc | Pyridine and piperidine compounds and process of making same |
US2957880A (en) * | 1953-12-23 | 1960-10-25 | Ciba Pharm Prod Inc | Process for the conversion of stereoisomers |
GB9606417D0 (en) * | 1996-03-27 | 1996-06-05 | Chiroscience Ltd | Asymmetric cyclisation |
-
1997
- 1997-07-16 US US08/895,428 patent/US5859249A/en not_active Expired - Fee Related
- 1997-07-29 CA CA002211934A patent/CA2211934C/en not_active Expired - Fee Related
-
1998
- 1998-02-18 ES ES98400387T patent/ES2178121T3/es not_active Expired - Lifetime
- 1998-02-18 DE DE69805676T patent/DE69805676T2/de not_active Expired - Lifetime
- 1998-02-18 EP EP98400387A patent/EP0860432B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5859249A (en) | 1999-01-12 |
DE69805676T2 (de) | 2003-01-23 |
EP0860432B1 (en) | 2002-06-05 |
CA2211934C (en) | 2005-10-18 |
EP0860432A1 (en) | 1998-08-26 |
CA2211934A1 (en) | 1998-08-19 |
DE69805676D1 (de) | 2002-07-11 |
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