ES2177556T3 - Seleccion genetica de proteinas capacitadas para la fijacion de un ligando mediante la transduccion de señales en microorganismos. - Google Patents

Seleccion genetica de proteinas capacitadas para la fijacion de un ligando mediante la transduccion de señales en microorganismos.

Info

Publication number
ES2177556T3
ES2177556T3 ES94108620T ES94108620T ES2177556T3 ES 2177556 T3 ES2177556 T3 ES 2177556T3 ES 94108620 T ES94108620 T ES 94108620T ES 94108620 T ES94108620 T ES 94108620T ES 2177556 T3 ES2177556 T3 ES 2177556T3
Authority
ES
Spain
Prior art keywords
microorganisms
proteins
binding
transduction
trained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94108620T
Other languages
English (en)
Inventor
Hans-Joachim Fritz
Frank Hennecke
Harald Kolmar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2177556T3 publication Critical patent/ES2177556T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA SELECCION GENETICA DE PROTEINAS CON CAPACIDAD DE FORMACION DE LIGANDURAS EN MICROORGANISMOS, CARACTERIZADO PORQUE SE PRESENTA UNA PROTEINA EXTRA CITOPLASMATICA CON CAPACIDAD DE FORMACION DE LIGANDURAS Y LA SEÑAL DE LA FORMACION DE LIGANDURAS SE DERIVA MEDIANTE TRANSDUCCION DE SEÑAL EN LA MAQUINARIA BIOSINTETICA DEL MICROORGANISMO PARA LA EXPRESION DE UNA FUNCION DETECTABLE Y/O SELECCIONABLE. CON ELLO SE DAN A CONOCER MICROORGANISMOS APROPIADOS PARA ESTE PROCEDIMIENTO Y SU REPLICA, ASI COMO PROCEDIMIENTO PARA SU ELABORACION.
ES94108620T 1993-06-10 1994-06-06 Seleccion genetica de proteinas capacitadas para la fijacion de un ligando mediante la transduccion de señales en microorganismos. Expired - Lifetime ES2177556T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4319296A DE4319296A1 (de) 1993-06-10 1993-06-10 Genetische Selektion von zur Ligandenbindung befähigten Proteinen mittels Signaltransduktion in Mikroorganismen

Publications (1)

Publication Number Publication Date
ES2177556T3 true ES2177556T3 (es) 2002-12-16

Family

ID=6490074

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94108620T Expired - Lifetime ES2177556T3 (es) 1993-06-10 1994-06-06 Seleccion genetica de proteinas capacitadas para la fijacion de un ligando mediante la transduccion de señales en microorganismos.

Country Status (11)

Country Link
US (1) US5882924A (es)
EP (1) EP0630968B1 (es)
JP (1) JPH06343472A (es)
KR (1) KR100354577B1 (es)
AT (1) ATE218619T1 (es)
AU (1) AU682859B2 (es)
CA (1) CA2125536A1 (es)
DE (2) DE4319296A1 (es)
DK (1) DK0630968T3 (es)
ES (1) ES2177556T3 (es)
PT (1) PT630968E (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521066A (en) * 1993-09-13 1996-05-28 Bristol-Myers Squibb Company Periplasmic membrane-bound system for detecting protein-protein interactions
DE19951694A1 (de) * 1999-10-27 2001-05-03 Alexander Cherkasky Verfahren zur Regulierung der Expression von Transgenen in spezifischen Expressionssystemen, wie z.B. in Immunzellen B, T und Makrophagen in vitro und vivo
AU2002243280A1 (en) * 2000-10-23 2002-06-24 Engeneos, Inc. Engineered stimulus-responsive switches
CA2445889A1 (en) * 2001-05-02 2002-11-07 University Of South Florida Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
USD971639S1 (en) 2019-04-30 2022-12-06 Tactical Target Stands, Llc Target stand

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521066A (en) * 1993-09-13 1996-05-28 Bristol-Myers Squibb Company Periplasmic membrane-bound system for detecting protein-protein interactions

Also Published As

Publication number Publication date
PT630968E (pt) 2002-10-31
KR100354577B1 (ko) 2004-12-31
ATE218619T1 (de) 2002-06-15
DK0630968T3 (da) 2002-09-16
AU6461494A (en) 1994-12-15
JPH06343472A (ja) 1994-12-20
KR950000874A (ko) 1995-01-03
CA2125536A1 (en) 1994-12-11
EP0630968A3 (de) 1995-04-19
EP0630968A2 (de) 1994-12-28
EP0630968B1 (de) 2002-06-05
DE4319296A1 (de) 1994-12-15
DE59410127D1 (de) 2002-07-11
US5882924A (en) 1999-03-16
AU682859B2 (en) 1997-10-23

Similar Documents

Publication Publication Date Title
EP0712862A3 (en) Selective acylation of epsilon-amino groups
AU2894289A (en) Domain-modified constant region antibodies
DE3783191D1 (de) Verfahren und mittel zur herstellung eines proteins mit der gleichen igg-spezifizitaet wie protein g.
EP0770129A4 (en) DERIVATIVES OF ZINKFINGERPROTEINEN AND METHODS
AU2152299A (en) Multivalent antigen-binding proteins
IL131016A0 (en) Selection of proteins using rna-protein fusions
DE69020143D1 (de) Verfahren zur verwendung und herstellung von peptiden.
ATE393822T1 (de) Nukleinsäure bindende proteine
ATE522610T1 (de) Menschliche, metabotrope glutamatrezeptor- subtypen (hmr6) und verwandte dns-verbindungen
ATE268385T1 (de) Mykrobakterielle proteine, mikroorganismen welche diese produzieren und ihre verwendung als impfstoff und zum nachweis von zuberkulose
NZ296748A (en) Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods
DE69839444D1 (de) Smad 6 und dessen anwendungen
WO1999038013A3 (de) Verfahren zur gleichzeitigen identifizierung von proteinen und ihren bindungspartnern
WO1996007738A3 (en) Modified human c3 proteins
ES2177556T3 (es) Seleccion genetica de proteinas capacitadas para la fijacion de un ligando mediante la transduccion de señales en microorganismos.
WO1999003993A3 (en) Suppressors of cytokine signaling; related reagents
DE69634077D1 (de) Haemophilus adhäsionsproteinen
KR940027658A (ko) 트롬빈 결합성 물질 및 이의 제조방법
ATE215964T1 (de) Phrothrombin und thrombin bindende peptide.
WO1997020928A1 (en) Novel semaphorin z and gene encoding the same
KR910005885A (ko) 단백질 c의 활성화방법
EP0601318A3 (de) Verfahren zur Herstellung von Konjugaten aus einem spezifischen Bindungspartner und einem kohlenhydrathaltigen Protein.
AU7198391A (en) Functional assay for determining the protein s activity
DE59309692D1 (de) Verfahren zur Bestimmung von Rheumafaktoren und Mittel zur Durchführung des Verfahrens
SE8800981D0 (sv) A recombinant fusion protein, its use and a recombinant vector