ES2175400T3 - Procedimiento para el diagnostico diferencial de los diferentes estadios de la enfermedad de alzheimer. - Google Patents
Procedimiento para el diagnostico diferencial de los diferentes estadios de la enfermedad de alzheimer.Info
- Publication number
- ES2175400T3 ES2175400T3 ES97920514T ES97920514T ES2175400T3 ES 2175400 T3 ES2175400 T3 ES 2175400T3 ES 97920514 T ES97920514 T ES 97920514T ES 97920514 T ES97920514 T ES 97920514T ES 2175400 T3 ES2175400 T3 ES 2175400T3
- Authority
- ES
- Spain
- Prior art keywords
- disease
- alzheimer
- activated
- lymphocytes
- activation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA DIAGNOSTICAR LA ENFERMEDAD DE ALZHEIMER Y ENFERMEDADES CON UNA ETIOLOGIA SIMILAR, ASI COMO A MEDIOS FARMACEUTICOS PARA SU TRATAMIENTO. LOS CAMPOS DE APLICACION DE LA INVENCION SON LA MEDICINA Y LA INDUSTRIA FARMACEUTICA. EL PUNTO DE PARTIDA DE LA INVENCION ES EL SORPRENDENTE DESCUBRIMIENTO DE QUE UN FACTOR CAUSANTE DE LA ENFERMEDAD DE ALZHEIMER ES LA PRODUCCION PATOLOGICA DE LINFOCITOS T ACTIVADOS AUTOESPECIFICOS EN LA SANGRE PERIFERICA. LOS LINFOCITOS T ACTIVADOS ATRAVIESAN LA BARRERA HEMATOENCEFALICA, SUCUMBEN FRENTE A LA APOPTOSIS AL ACTUAR JUNTO CON CELULAS DE LA MICROGLIA Y, CON LA ACTIVACION DE LA MICROGLIA, ACTIVAN EL PROCESO DE ENCENDIDO NEUROTOXICO CARACTERISTICO. EL PROCEDIMIENTO CONFORME A LA INVENCION UTILIZA UNA MUESTRA DE SANGRE PERIFERICA, A PARTIR DE LA CUAL SE DIAGNOSTICA LA ENFERMEDAD DE ALZHEIMER CON BASE EN LA PROPORCION DE CELULAS MONONUCLEARES APOPTOSICAS (MURIENTES), EN LA ACTIVACION DE MONOCITOS/MACROFAGOS O EN AMBOS METODOS EN COMBINACION. EL MEDIO CONFORME A LA INVENCION CONTIENE COMO SUSTANCIA ACTIVA UN FACTOR QUE AUMENTA LA ACTIVIDAD FAGOCITICA EN EL CUERPO Y EN UN ORGANO ESPECIFICO, EN ESPECIAL EN EL CEREBRO, O BIEN UNA SUSTANCIA QUE SE FIJA SELECTIVAMENTE A MARCADORES DE ACTIVACION O RECEPTORES DE ADHESION DE LINFOCITOS L ACTIVADOS O A RECEPTORES DE ADHESION DE CELULAS ENDOTELIALES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19608519A DE19608519A1 (de) | 1996-03-06 | 1996-03-06 | Mittel zur Therapie der Alzheimer-Krankheit und von Krankheiten analoger Ursache |
DE1996132671 DE19632671A1 (de) | 1996-08-14 | 1996-08-14 | Verfahren zur Diagnostik der Alzheimer-Krankheit |
DE1996140348 DE19640348A1 (de) | 1996-09-20 | 1996-09-20 | Mittel zur Therapie der Alzheimer-Krankheit |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175400T3 true ES2175400T3 (es) | 2002-11-16 |
Family
ID=27215983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97920514T Expired - Lifetime ES2175400T3 (es) | 1996-03-06 | 1997-03-03 | Procedimiento para el diagnostico diferencial de los diferentes estadios de la enfermedad de alzheimer. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0885392B1 (es) |
AT (1) | ATE213067T1 (es) |
DE (1) | DE59706309D1 (es) |
ES (1) | ES2175400T3 (es) |
WO (1) | WO1997033175A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198334B2 (en) | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
GB0802851D0 (en) | 2008-02-15 | 2008-03-26 | Medinnova As | Diagnostic method |
DE102009021553A1 (de) | 2009-05-09 | 2010-11-18 | Kettenbach Gmbh & Co. Kg | Härtbare Zusammensetzungen, daraus hergestellte gehärtete Produkte und deren Verwendung |
AU2011336895A1 (en) * | 2010-11-24 | 2013-06-06 | Elan Pharmaceuticals, Inc. | Phagocytic activity as a marker of synucleinopathic disease |
-
1997
- 1997-03-03 AT AT97920514T patent/ATE213067T1/de not_active IP Right Cessation
- 1997-03-03 DE DE59706309T patent/DE59706309D1/de not_active Expired - Lifetime
- 1997-03-03 EP EP97920514A patent/EP0885392B1/de not_active Expired - Lifetime
- 1997-03-03 ES ES97920514T patent/ES2175400T3/es not_active Expired - Lifetime
- 1997-03-03 WO PCT/DE1997/000522 patent/WO1997033175A1/de active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE213067T1 (de) | 2002-02-15 |
EP0885392B1 (de) | 2002-02-06 |
DE59706309D1 (de) | 2002-03-21 |
WO1997033175A1 (de) | 1997-09-12 |
EP0885392A1 (de) | 1998-12-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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