ES2174794T3 - Nuevos inhibidores de proteina: prenil transferasa. - Google Patents

Nuevos inhibidores de proteina: prenil transferasa.

Info

Publication number
ES2174794T3
ES2174794T3 ES00200372T ES00200372T ES2174794T3 ES 2174794 T3 ES2174794 T3 ES 2174794T3 ES 00200372 T ES00200372 T ES 00200372T ES 00200372 T ES00200372 T ES 00200372T ES 2174794 T3 ES2174794 T3 ES 2174794T3
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
prenil
transferasa
protein inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00200372T
Other languages
English (en)
Inventor
Herman Steven Overkleeft
Steven Hendrik Leonar Verhelst
Nicolaas Johannes Meeuwenoord
Elsbet Jantine Pieterman
Louis Hartog Cohen
Mark Overhand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Universiteit Leiden
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Universiteit Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO, Universiteit Leiden filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Application granted granted Critical
Publication of ES2174794T3 publication Critical patent/ES2174794T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

Un análogo peptídico adecuado como inhibidor de proteína:prenil transferasas que tiene la fórmula 1: en la que: R1 es hidrógeno o un grupo protector de tiol; cada R2 y R3 es independientemente hidrógeno o alquilo C1-C4; R4 es hidrógeno, alquilo C1-C4, acilo C1-C4 o peptidilo; R5 es hidrógeno o alquilo C1-C4; R6 es hidrógeno o alquilo C1-C4 opcionalmente sustituido con hidroxi, fenilo, hidroxifenilo, indolilo, imidazolilo, mercapto, metiltio, amino, carboxilo, carbamoílo, ureido, amidino o guanidino; A es un enlace directo o una cadena alquileno C1-C4 saturada o insaturada, opcionalmente interrumpida por uno o más átomos de oxígeno, azufre o nitrógeno, opcionalmente sustituida con hidroxi, oxo, alquilo C1-C4, alquilideno C1-C4, alcoxi C1-C4, aliloxi, benciloxi, aciloxi C1-C8, alquil C1-C3 (Id) enodioxi, amino, alquilamino C1-C4 o hidroxialquilo C1-C4; (H) representa un átomo de hidrógeno si A está saturado y puede estar ausente si A está insaturado; Y representa un grupo oxo o dos átomos dehidrógeno; Z es oxígeno, azufre, imino o alquilo C1-C8, arilo o acilimino; m es 0,1 ó 2; y n es 0 ó 1.
ES00200372T 1999-02-03 2000-02-03 Nuevos inhibidores de proteina: prenil transferasa. Expired - Lifetime ES2174794T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99200316 1999-02-03

Publications (1)

Publication Number Publication Date
ES2174794T3 true ES2174794T3 (es) 2002-11-16

Family

ID=8239861

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00200372T Expired - Lifetime ES2174794T3 (es) 1999-02-03 2000-02-03 Nuevos inhibidores de proteina: prenil transferasa.

Country Status (7)

Country Link
US (1) US6376468B1 (es)
EP (1) EP1028117B1 (es)
JP (1) JP2000226383A (es)
AT (1) ATE219072T1 (es)
DE (1) DE60000203T2 (es)
DK (1) DK1028117T3 (es)
ES (1) ES2174794T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056947B2 (en) * 2002-07-05 2006-06-06 Georgia Tech Research Corp. Aza-peptide epoxides
US8013014B2 (en) * 2002-07-05 2011-09-06 Georgia Tech Research Corporation Aza-peptide epoxides
EP1723124A1 (en) * 2004-02-18 2006-11-22 Georgia Tech Research Corporation Propenoyl hydrazides
US20060014939A1 (en) * 2004-07-15 2006-01-19 Chakraborty Tushar K Novel C6-substituted furanoid sugar amino acids and improved process for preparing the same
US20090183503A1 (en) * 2008-01-18 2009-07-23 Alberto Verdesi Exhaust apparatus
WO2009148709A1 (en) * 2008-04-16 2009-12-10 University Of Utah Research Foundation Pharmacological targeting of vascular malformations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673927B2 (en) * 1996-02-16 2004-01-06 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
DE60000203D1 (de) 2002-07-18
EP1028117B1 (en) 2002-06-12
ATE219072T1 (de) 2002-06-15
EP1028117A3 (en) 2000-08-23
EP1028117A2 (en) 2000-08-16
US6376468B1 (en) 2002-04-23
JP2000226383A (ja) 2000-08-15
DK1028117T3 (da) 2002-09-16
DE60000203T2 (de) 2003-02-06

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