ES2173927T3 - Procedimiento para la preparacion de un concentrado de inter-alfa-tripsina inhibidor de uso terapeutico, y concentrado obtenido. - Google Patents

Procedimiento para la preparacion de un concentrado de inter-alfa-tripsina inhibidor de uso terapeutico, y concentrado obtenido.

Info

Publication number
ES2173927T3
ES2173927T3 ES94931070T ES94931070T ES2173927T3 ES 2173927 T3 ES2173927 T3 ES 2173927T3 ES 94931070 T ES94931070 T ES 94931070T ES 94931070 T ES94931070 T ES 94931070T ES 2173927 T3 ES2173927 T3 ES 2173927T3
Authority
ES
Spain
Prior art keywords
concentrate
pct
inter
therapeutic use
tripsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931070T
Other languages
English (en)
Inventor
Catherine Michalski
Jacques Mizon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AETSRN
Association pour lEssor de la Transfusion Sanguine dans la Region Nord
Original Assignee
AETSRN
Association pour lEssor de la Transfusion Sanguine dans la Region Nord
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AETSRN, Association pour lEssor de la Transfusion Sanguine dans la Region Nord filed Critical AETSRN
Application granted granted Critical
Publication of ES2173927T3 publication Critical patent/ES2173927T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

_LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE ITI A PARTIR DE PLASMA HUMANO QUE COMPRENDE DOS ETAPAS DE CROMATOGRAFIA SOBRE GELES INTERCAMBIADORES DE ANIONES Y UNA ETAPA DE CROMATOGRAFIA DE AFINIDAD SOBRE HEPARINA INMOVILIZADA. EL PROCEDIMIENTO COMPRENDE TAMBIEN UN TRATAMIENTO DE INACTIVACION VIRAL. EL CONCENTRADO DE ITI OBTENIDO ES DE UNA CALIDAD ADAPTADA A UN USO TERAPEUTICO.
ES94931070T 1993-10-18 1994-10-17 Procedimiento para la preparacion de un concentrado de inter-alfa-tripsina inhibidor de uso terapeutico, y concentrado obtenido. Expired - Lifetime ES2173927T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9312346A FR2711371B1 (fr) 1993-10-18 1993-10-18 Procédé de préparation d'un concentré d'inter-alpha-trypsine inhibiteur à usage thérapeutique et concentré obtenu.

Publications (1)

Publication Number Publication Date
ES2173927T3 true ES2173927T3 (es) 2002-11-01

Family

ID=9451908

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931070T Expired - Lifetime ES2173927T3 (es) 1993-10-18 1994-10-17 Procedimiento para la preparacion de un concentrado de inter-alfa-tripsina inhibidor de uso terapeutico, y concentrado obtenido.

Country Status (12)

Country Link
US (1) US5777081A (es)
EP (1) EP0724600B1 (es)
JP (1) JP3650937B2 (es)
AT (1) ATE213252T1 (es)
AU (1) AU7996294A (es)
CA (1) CA2174231C (es)
DE (1) DE69429868T2 (es)
DK (1) DK0724600T3 (es)
ES (1) ES2173927T3 (es)
FR (1) FR2711371B1 (es)
PT (1) PT724600E (es)
WO (1) WO1995011260A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3626982B2 (ja) * 1997-08-29 2005-03-09 アークレイ株式会社 タンパク質分解酵素阻害物質の測定方法およびそれに用いる測定キット
US6596705B1 (en) 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin
US6660482B1 (en) 2000-02-28 2003-12-09 Rhode Island Hospital Inter-alpha-trypsin inhibitor as a marker for sepsis
JP2004511492A (ja) * 2000-10-13 2004-04-15 オクタファルマ　アクチェン　ゲゼルシャフト ビクニンを含む血漿画分、その調製方法、およびその使用
WO2003088980A1 (en) * 2002-04-18 2003-10-30 Embury Stephen H Method and composition for preventing pain in sickle cell patients
EP3087991A1 (en) 2003-11-08 2016-11-02 Prothera Biologics Composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
CA2726281C (en) 2008-05-28 2023-04-18 Prothera Biologics, Llc Preparation and composition of inter-alpha inhibitor proteins from blood
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
WO2012012773A1 (en) 2010-07-23 2012-01-26 Baxter International Inc. Manufacture of inter -alpha - inhibitor proteins (iaip) from plasma
US9572872B2 (en) 2012-09-09 2017-02-21 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
CN103880951B (zh) * 2014-03-31 2016-03-30 南昌市万华生化制品有限公司 一种通过乌司他丁亲和层析介质制备纯品乌司他丁的方法
WO2017066683A1 (en) * 2015-10-15 2017-04-20 Plasma Technologies, Llc Methods for extracting proteins from blood plasma
CN109776674B (zh) * 2019-02-19 2020-01-17 广东天普生化医药股份有限公司 纯化的乌司他丁及其制备方法和含有该乌司他丁的药物组合物
US11725043B2 (en) 2020-03-05 2023-08-15 DiaMedica USA Inc. Ulinastatin polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1434199A (fr) * 1964-01-10 1966-04-08 Behringwerke Ag Procédé d'isolement d'inhibiteurs de la plasmine et de la trypsine à partir de liquides organiques d'origine humaine ou animale
US4119774A (en) * 1976-03-05 1978-10-10 Ab Kabi Heparin purification method
AT368883B (de) * 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
US4760130A (en) * 1984-12-06 1988-07-26 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
DE3877529T2 (de) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
US5445958A (en) * 1987-12-22 1995-08-29 National Blood Authority Process for purifying blood clotting factors

Also Published As

Publication number Publication date
US5777081A (en) 1998-07-07
ATE213252T1 (de) 2002-02-15
EP0724600A1 (fr) 1996-08-07
AU7996294A (en) 1995-05-08
PT724600E (pt) 2002-07-31
WO1995011260A1 (fr) 1995-04-27
FR2711371A1 (fr) 1995-04-28
EP0724600B1 (fr) 2002-02-13
DK0724600T3 (da) 2002-05-27
JP3650937B2 (ja) 2005-05-25
CA2174231C (fr) 2004-06-01
FR2711371B1 (fr) 1995-12-29
DE69429868T2 (de) 2002-09-19
CA2174231A1 (fr) 1995-04-27
DE69429868D1 (de) 2002-03-21
JPH09503775A (ja) 1997-04-15

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