ES2173866T3 - Derivados de hidroisoquinolina. - Google Patents

Derivados de hidroisoquinolina.

Info

Publication number
ES2173866T3
ES2173866T3 ES92913507T ES92913507T ES2173866T3 ES 2173866 T3 ES2173866 T3 ES 2173866T3 ES 92913507 T ES92913507 T ES 92913507T ES 92913507 T ES92913507 T ES 92913507T ES 2173866 T3 ES2173866 T3 ES 2173866T3
Authority
ES
Spain
Prior art keywords
pct
alkoxy
hydroxy
hydrogen
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913507T
Other languages
English (en)
Inventor
Roberto Colle
Vittorio Vecchietti
Giulio Dondio
Silvano Ronzoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
GlaxoSmithKline SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT001863 external-priority patent/IT1250645B/it
Priority claimed from ITMI920563A external-priority patent/IT1254256B/it
Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA
Application granted granted Critical
Publication of ES2173866T3 publication Critical patent/ES2173866T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

SE PRESENTA UN COMPUESTO DE LA FORMULA (I) EN LA CUAL, R ES ALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, ALQUENILO, ARILO, ARALQUILO O ALQUILO DE FURAN-2-ILO LINEAL O RAMIFICADO; R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, SON CADA UNA HIDROGENO, HIDROXIDO, ALCOXIDO O HALOGENO; R3 ES HIDROGENO, HIDROXIDO O ALCOXIDO; "HET" ES UN ANILLO HETEROCICLICO SIMPLE O FUNDIDO, OPCIONALMENTE SUSTITUIDO, QUE CONTIENE ENTRE 5 O 6 ATOMOS EN EL ANILLO Y QUE COMPRENDE HASTA 4 HETEROATOMOS EN EL ANILLO O EN CADA UNO DE LOS ANILLOS, SELECCIONADOS ENTRE OXIGENO, NITROGENO O AZUFRE; R4 Y R5, QUE PUEDEN SER IGUALES O DIFERENTES, SON CADA UNA HIDROGENO, ALQUILO, HALOGENO, NITRO, CF, CIANO, ALCOXICARBONIL, NH, ALQUILCARBONILAMINO, HIDROXIDO, ALCOXIDO O BENCIL; LOS COMPUESTOS SON ANTAGONISTAS SELECTIVOS DEL RECEPTOR DELTA Y SON UTILES EN EL TRATAMIENTO DEL DOLOR.
ES92913507T 1991-07-05 1992-07-01 Derivados de hidroisoquinolina. Expired - Lifetime ES2173866T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001863 IT1250645B (it) 1991-07-05 1991-07-05 Derivati di idroisochinolina
ITMI920563A IT1254256B (it) 1992-03-11 1992-03-11 Derivati di idroisochinolina

Publications (1)

Publication Number Publication Date
ES2173866T3 true ES2173866T3 (es) 2002-11-01

Family

ID=26330739

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913507T Expired - Lifetime ES2173866T3 (es) 1991-07-05 1992-07-01 Derivados de hidroisoquinolina.

Country Status (15)

Country Link
US (1) US5441956A (es)
EP (1) EP0596897B1 (es)
JP (1) JP3253077B2 (es)
KR (1) KR100241662B1 (es)
AT (1) ATE214390T1 (es)
AU (1) AU662007B2 (es)
CA (1) CA2112744A1 (es)
DE (1) DE69232484T2 (es)
ES (1) ES2173866T3 (es)
IE (1) IE922187A1 (es)
MX (1) MX9203939A (es)
NZ (1) NZ243436A (es)
PT (1) PT100658A (es)
TW (1) TW211567B (es)
WO (1) WO1993001186A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69430373T2 (de) * 1993-08-06 2002-12-12 Smithkline Beecham S.P.A., Baranzate Di Bollate Hydroisochinolinderivate
US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
JP3315268B2 (ja) 1994-09-22 2002-08-19 株式会社東芝 画像形成装置
CA2264928A1 (en) * 1997-07-09 1999-01-21 Koji Kawai Antitussives
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
EP1234828A4 (en) 1999-11-30 2005-01-12 Toray Industries MEANS TO IMPROVE LEARNING OR MEMORY
US20070135425A1 (en) * 2001-05-04 2007-06-14 Amgen Inc. Fused heterocyclic compounds
WO2002089729A2 (en) * 2001-05-04 2002-11-14 Tularik Inc. Fused heterocyclic compounds
US6809104B2 (en) * 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
EP1562943A1 (en) * 2002-11-06 2005-08-17 Amgen Inc. Fused heterocyclic compounds
KR102018843B1 (ko) 2018-12-08 2019-11-04 김태현 공조설비의 관 연결구조

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1024149A (en) * 1972-07-20 1978-01-10 E.I. Du Pont De Nemours And Company 4.alpha.-ARYL-TRANS-DECAHYDROISOQUINOLINES
ES2098357T3 (es) * 1990-06-05 1997-05-01 Toray Industries Derivado de indol.
AU644451B2 (en) * 1990-06-05 1993-12-09 Toray Industries, Inc. Indole derivative

Also Published As

Publication number Publication date
NZ243436A (en) 1995-06-27
DE69232484D1 (de) 2002-04-18
EP0596897B1 (en) 2002-03-13
DE69232484T2 (de) 2002-10-31
JPH07502485A (ja) 1995-03-16
CA2112744A1 (en) 1993-01-21
US5441956A (en) 1995-08-15
JP3253077B2 (ja) 2002-02-04
IE922187A1 (en) 1993-01-13
WO1993001186A1 (en) 1993-01-21
ATE214390T1 (de) 2002-03-15
MX9203939A (es) 1993-04-01
EP0596897A1 (en) 1994-05-18
AU2194892A (en) 1993-02-11
TW211567B (es) 1993-08-21
PT100658A (pt) 1993-09-30
KR100241662B1 (ko) 2000-03-02
AU662007B2 (en) 1995-08-17

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