DE69430373T2 - Hydroisochinolinderivate - Google Patents

Hydroisochinolinderivate

Info

Publication number
DE69430373T2
DE69430373T2 DE69430373T DE69430373T DE69430373T2 DE 69430373 T2 DE69430373 T2 DE 69430373T2 DE 69430373 T DE69430373 T DE 69430373T DE 69430373 T DE69430373 T DE 69430373T DE 69430373 T2 DE69430373 T2 DE 69430373T2
Authority
DE
Germany
Prior art keywords
pct
sec
nitrogen
zero
carbon atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430373T
Other languages
English (en)
Other versions
DE69430373D1 (de
Inventor
Giulio Dondio
Silvano Ronzoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
SmithKline Beecham SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT93MI001788A external-priority patent/IT1265043B1/it
Priority claimed from ITMI940202A external-priority patent/IT1274008B/it
Application filed by SmithKline Beecham SpA filed Critical SmithKline Beecham SpA
Application granted granted Critical
Publication of DE69430373D1 publication Critical patent/DE69430373D1/de
Publication of DE69430373T2 publication Critical patent/DE69430373T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE69430373T 1993-08-06 1994-07-14 Hydroisochinolinderivate Expired - Fee Related DE69430373T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT93MI001788A IT1265043B1 (it) 1993-08-06 1993-08-06 Derivati di idroisochinolina
ITMI940202A IT1274008B (it) 1994-02-04 1994-02-04 Derivati di idroisochinolina
PCT/EP1994/002325 WO1995004734A1 (en) 1993-08-06 1994-07-14 Hydroisoquinoline derivatives

Publications (2)

Publication Number Publication Date
DE69430373D1 DE69430373D1 (de) 2002-05-16
DE69430373T2 true DE69430373T2 (de) 2002-12-12

Family

ID=26331034

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430373T Expired - Fee Related DE69430373T2 (de) 1993-08-06 1994-07-14 Hydroisochinolinderivate

Country Status (11)

Country Link
US (1) US5731322A (de)
EP (1) EP0712402B1 (de)
JP (1) JPH09505030A (de)
CN (1) CN1043641C (de)
AT (1) ATE215949T1 (de)
AU (1) AU690576B2 (de)
CA (1) CA2168853A1 (de)
DE (1) DE69430373T2 (de)
ES (1) ES2173921T3 (de)
NZ (1) NZ271338A (de)
WO (1) WO1995004734A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CA2462953C (en) 2001-10-15 2011-01-04 Janssen Pharmaceutica N.V. Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP1889198B1 (de) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatiksystem
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2399577A1 (de) 2006-09-12 2011-12-28 Adolor Corporation Verwendung von N-haltigen Spiroverbindungen zur Verbesserung der kognitiven Funktion
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US7645801B2 (en) * 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (de) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermale freisetzungszusammensetzung mit wirkstoff-calciumphosphat-partikelkomplexen und anwendungsverfahren
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012094618A1 (en) 2011-01-07 2012-07-12 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
PL3848027T3 (pl) 2013-11-25 2023-07-24 Corcept Therapeutics Incorporated Skondensowane oktahydrozwiązki azadekaliny jako modulatory receptora glukokortykoidowego
AU2018244928B2 (en) 2017-03-31 2023-10-19 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat cervical cancer
WO2020132023A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
BR112021015129A2 (pt) 2019-02-22 2021-09-28 Corcept Therapeutics Incorporated Método para tratar um paciente que sofre de hipercortisolemia e um sintoma ou comorbidade da mesma
CN113105411B (zh) * 2019-06-28 2023-03-17 深圳市三启药物开发有限公司 腙酰胺类衍生物及药物组合物
EP4072556A4 (de) 2019-12-11 2024-01-03 Corcept Therapeutics Incorporated Verfahren zur behandlung von antipsychotikainduzierter gewichtszunahme mit miricorilant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260762A (en) * 1979-09-10 1981-04-07 Hoffmann-La Roche Inc. Octahydro-1H-pyrrolo[2,3-g]isoquinolines
AU662007B2 (en) * 1991-07-05 1995-08-17 Smithkline Beecham Farmaceutici S.P.A. Hydroisoquinoline derivatives

Also Published As

Publication number Publication date
EP0712402A1 (de) 1996-05-22
CN1132510A (zh) 1996-10-02
DE69430373D1 (de) 2002-05-16
CN1043641C (zh) 1999-06-16
AU7493794A (en) 1995-02-28
ES2173921T3 (es) 2002-11-01
NZ271338A (en) 1998-06-26
CA2168853A1 (en) 1995-02-16
AU690576B2 (en) 1998-04-30
WO1995004734A1 (en) 1995-02-16
EP0712402B1 (de) 2002-04-10
US5731322A (en) 1998-03-24
ATE215949T1 (de) 2002-04-15
JPH09505030A (ja) 1997-05-20

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee