DE69430373D1 - Hydroisochinolinderivate - Google Patents

Hydroisochinolinderivate

Info

Publication number
DE69430373D1
DE69430373D1 DE69430373T DE69430373T DE69430373D1 DE 69430373 D1 DE69430373 D1 DE 69430373D1 DE 69430373 T DE69430373 T DE 69430373T DE 69430373 T DE69430373 T DE 69430373T DE 69430373 D1 DE69430373 D1 DE 69430373D1
Authority
DE
Germany
Prior art keywords
pct
sec
nitrogen
zero
carbon atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430373T
Other languages
English (en)
Other versions
DE69430373T2 (de
Inventor
Giulio Dondio
Silvano Ronzoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
SmithKline Beecham SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT93MI001788A external-priority patent/IT1265043B1/it
Priority claimed from ITMI940202A external-priority patent/IT1274008B/it
Application filed by SmithKline Beecham SpA filed Critical SmithKline Beecham SpA
Application granted granted Critical
Publication of DE69430373D1 publication Critical patent/DE69430373D1/de
Publication of DE69430373T2 publication Critical patent/DE69430373T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE69430373T 1993-08-06 1994-07-14 Hydroisochinolinderivate Expired - Fee Related DE69430373T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT93MI001788A IT1265043B1 (it) 1993-08-06 1993-08-06 Derivati di idroisochinolina
ITMI940202A IT1274008B (it) 1994-02-04 1994-02-04 Derivati di idroisochinolina
PCT/EP1994/002325 WO1995004734A1 (en) 1993-08-06 1994-07-14 Hydroisoquinoline derivatives

Publications (2)

Publication Number Publication Date
DE69430373D1 true DE69430373D1 (de) 2002-05-16
DE69430373T2 DE69430373T2 (de) 2002-12-12

Family

ID=26331034

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430373T Expired - Fee Related DE69430373T2 (de) 1993-08-06 1994-07-14 Hydroisochinolinderivate

Country Status (11)

Country Link
US (1) US5731322A (de)
EP (1) EP0712402B1 (de)
JP (1) JPH09505030A (de)
CN (1) CN1043641C (de)
AT (1) ATE215949T1 (de)
AU (1) AU690576B2 (de)
CA (1) CA2168853A1 (de)
DE (1) DE69430373T2 (de)
ES (1) ES2173921T3 (de)
NZ (1) NZ271338A (de)
WO (1) WO1995004734A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
ES2278065T3 (es) 2001-10-15 2007-08-01 Janssen Pharmaceutica N.V. Nuevos derivados de 4-fenil-4-(1h-imidazol-2-il)-piperidina sustituida y su uso como agonistas selectivos de opioides delta no peptidos.
KR101255074B1 (ko) 2003-10-01 2013-04-16 아돌로 코포레이션 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법
US7087749B2 (en) * 2004-03-11 2006-08-08 Adolor Corporation Substituted piperidine compounds and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US20080119452A1 (en) 2006-09-12 2008-05-22 Dolle Roland E Methods for enhancing cognitive function
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
US7645801B2 (en) * 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103298343A (zh) 2011-01-07 2013-09-11 科赛普特治疗公司 类固醇和糖皮质激素受体拮抗剂组合疗法
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
KR102352737B1 (ko) 2013-11-25 2022-01-17 코어셉트 쎄라퓨틱스 인코포레이티드 옥타하이드로 융합된 아자데칼린 글루코코르티코이드 수용체 조절제
MX2019011543A (es) 2017-03-31 2019-12-16 Corcept Therapeutics Inc Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical.
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
BR112021010461A2 (pt) 2018-12-19 2021-08-24 Corcept Therapeutics Incorporated Formulação e dose unitária para administração oral de relacorilante
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
SG11202108964YA (en) 2019-02-22 2021-09-29 Corcept Therapeutics Inc Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
CN110330465B (zh) * 2019-06-28 2021-05-11 深圳市三启药物开发有限公司 腙酰胺类衍生物及其在制备防治脱发药物中的应用
EP4072556A4 (de) 2019-12-11 2024-01-03 Corcept Therapeutics Inc Verfahren zur behandlung von antipsychotikainduzierter gewichtszunahme mit miricorilant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260762A (en) * 1979-09-10 1981-04-07 Hoffmann-La Roche Inc. Octahydro-1H-pyrrolo[2,3-g]isoquinolines
ATE214390T1 (de) * 1991-07-05 2002-03-15 Smithkline Becham S P A Hydroisochinolinderivate

Also Published As

Publication number Publication date
ES2173921T3 (es) 2002-11-01
WO1995004734A1 (en) 1995-02-16
AU690576B2 (en) 1998-04-30
NZ271338A (en) 1998-06-26
US5731322A (en) 1998-03-24
ATE215949T1 (de) 2002-04-15
EP0712402A1 (de) 1996-05-22
CN1132510A (zh) 1996-10-02
EP0712402B1 (de) 2002-04-10
CN1043641C (zh) 1999-06-16
DE69430373T2 (de) 2002-12-12
JPH09505030A (ja) 1997-05-20
CA2168853A1 (en) 1995-02-16
AU7493794A (en) 1995-02-28

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee