ATE215949T1 - Hydroisochinolinderivate - Google Patents
HydroisochinolinderivateInfo
- Publication number
- ATE215949T1 ATE215949T1 AT94924764T AT94924764T ATE215949T1 AT E215949 T1 ATE215949 T1 AT E215949T1 AT 94924764 T AT94924764 T AT 94924764T AT 94924764 T AT94924764 T AT 94924764T AT E215949 T1 ATE215949 T1 AT E215949T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- derivatives
- sec
- nitrogen
- zero
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical class C* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- LRGZZEOWQURWFK-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7-octahydroisoquinoline Chemical class C1NCCC2CCCC=C21 LRGZZEOWQURWFK-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93MI001788A IT1265043B1 (it) | 1993-08-06 | 1993-08-06 | Derivati di idroisochinolina |
| ITMI940202A IT1274008B (it) | 1994-02-04 | 1994-02-04 | Derivati di idroisochinolina |
| PCT/EP1994/002325 WO1995004734A1 (en) | 1993-08-06 | 1994-07-14 | Hydroisoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215949T1 true ATE215949T1 (de) | 2002-04-15 |
Family
ID=26331034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94924764T ATE215949T1 (de) | 1993-08-06 | 1994-07-14 | Hydroisochinolinderivate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5731322A (de) |
| EP (1) | EP0712402B1 (de) |
| JP (1) | JPH09505030A (de) |
| CN (1) | CN1043641C (de) |
| AT (1) | ATE215949T1 (de) |
| AU (1) | AU690576B2 (de) |
| CA (1) | CA2168853A1 (de) |
| DE (1) | DE69430373T2 (de) |
| ES (1) | ES2173921T3 (de) |
| NZ (1) | NZ271338A (de) |
| WO (1) | WO1995004734A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2147679B1 (de) | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Zusammensetzungen für den Blut-Hirn-Schrankentransport |
| NZ531679A (en) | 2001-10-15 | 2005-02-25 | Janssen Pharmaceutica Nv | Novel substituted 4-phenyl-4-[1H-imidazol-2-YL]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
| KR101255074B1 (ko) | 2003-10-01 | 2013-04-16 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| US7087749B2 (en) * | 2004-03-11 | 2006-08-08 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP2392258B1 (de) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP2063886A2 (de) | 2006-09-12 | 2009-06-03 | Adolor Corporation | Verwendung von stickstoff-haltigen spiroverbindungen zur steigerung kognitiver funktionen |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| US7645801B2 (en) * | 2007-01-29 | 2010-01-12 | Alaven Pharmaceutical Llc | Reduced irritant enema for treatment of inflammatory bowel disease (IBD) |
| PL3395372T3 (pl) | 2009-02-20 | 2022-07-25 | EnhanX Biopharm Inc. | Układ do dostarczania leków na bazie glutationu |
| CN102458374A (zh) | 2009-05-06 | 2012-05-16 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法 |
| US20100311782A1 (en) * | 2009-06-08 | 2010-12-09 | Adolor Corporation | Substituted piperidinylpropanoic acid compounds and methods of their use |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| CA2821524A1 (en) | 2011-01-07 | 2012-07-12 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| MX368167B (es) | 2013-11-25 | 2019-09-23 | Corcept Therapeutics Inc | Moduladores de receptores de glucocorticoides de azadecalina octahidro fusionada. |
| US10413540B2 (en) | 2017-03-31 | 2019-09-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| CN117281790A (zh) | 2018-12-19 | 2023-12-26 | 科塞普特治疗公司 | 含有瑞拉可兰、杂芳基-酮稠合的氮杂十氢化萘化合物的药物制剂 |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| EP3927345A4 (de) | 2019-02-22 | 2022-12-21 | Corcept Therapeutics Incorporated | Therapeutische verwendung von relacorilant, einem heteroaryl-keton-fusionierten azadecalin-glucocorticoid-rezeptor-modulator |
| CN113105411B (zh) * | 2019-06-28 | 2023-03-17 | 深圳市三启药物开发有限公司 | 腙酰胺类衍生物及药物组合物 |
| WO2021119432A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| KR20250073629A (ko) | 2022-10-06 | 2025-05-27 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 글루코코르티코이드 수용체 조절제의 제형 |
| EP4608402A1 (de) | 2022-10-28 | 2025-09-03 | Corcept Therapeutics Incorporated | Behandlung von amyotropher lateralsklerose mit dazucorilant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260762A (en) * | 1979-09-10 | 1981-04-07 | Hoffmann-La Roche Inc. | Octahydro-1H-pyrrolo[2,3-g]isoquinolines |
| US5441956A (en) * | 1991-07-05 | 1995-08-15 | Smithkline Beecham Farmaceutici S.P.A. | Hydroisoquinoline derivatives |
-
1994
- 1994-07-14 EP EP94924764A patent/EP0712402B1/de not_active Expired - Lifetime
- 1994-07-14 ES ES94924764T patent/ES2173921T3/es not_active Expired - Lifetime
- 1994-07-14 AT AT94924764T patent/ATE215949T1/de not_active IP Right Cessation
- 1994-07-14 DE DE69430373T patent/DE69430373T2/de not_active Expired - Fee Related
- 1994-07-14 CA CA002168853A patent/CA2168853A1/en not_active Abandoned
- 1994-07-14 JP JP7506175A patent/JPH09505030A/ja not_active Ceased
- 1994-07-14 AU AU74937/94A patent/AU690576B2/en not_active Ceased
- 1994-07-14 CN CN94193633A patent/CN1043641C/zh not_active Expired - Fee Related
- 1994-07-14 WO PCT/EP1994/002325 patent/WO1995004734A1/en not_active Ceased
- 1994-07-14 NZ NZ271338A patent/NZ271338A/en unknown
- 1994-07-14 US US08/591,514 patent/US5731322A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69430373T2 (de) | 2002-12-12 |
| DE69430373D1 (de) | 2002-05-16 |
| JPH09505030A (ja) | 1997-05-20 |
| AU690576B2 (en) | 1998-04-30 |
| EP0712402B1 (de) | 2002-04-10 |
| ES2173921T3 (es) | 2002-11-01 |
| NZ271338A (en) | 1998-06-26 |
| US5731322A (en) | 1998-03-24 |
| CN1132510A (zh) | 1996-10-02 |
| WO1995004734A1 (en) | 1995-02-16 |
| EP0712402A1 (de) | 1996-05-22 |
| AU7493794A (en) | 1995-02-28 |
| CN1043641C (zh) | 1999-06-16 |
| CA2168853A1 (en) | 1995-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE215949T1 (de) | Hydroisochinolinderivate | |
| TW367327B (en) | Heterocyclic compounds having tachykinin receptor antagonist activity, their preparation and their use | |
| DK0660707T3 (da) | Amantadin og beslægtede forbindelser til anvendelse i behandlingen af perifer neuropati | |
| PL326159A1 (en) | Heterocyclic fungicides | |
| NZ331001A (en) | Use of an opiate K receptor agonist as an antipruritic | |
| GB9514473D0 (en) | Chemical compounds | |
| MY102842A (en) | Calcium independent camp phosphodiesterase inhibitor antidepressant | |
| NO20003133D0 (no) | Anilidderivater, fremstilling og anvendelse derav | |
| AU2003301020A8 (en) | Isoquinolinone derivatives and their use as therapeutic agents | |
| TR200101398T2 (tr) | Pirolidin türevleri-CCR-3 reseptörü antagonistleri. | |
| MY119820A (en) | Guanidine mimics as factor xa inhibitors | |
| YU231790A (sh) | Spirocikli koji sadrže azot | |
| NZ233735A (en) | Heterocyclic substituted aminophenol derivatives | |
| UA35557C2 (uk) | Похідні 1,2,4-оксадіазолілфеноксіалкілізоксазолу, що мають противірусну активність та фармацевтична композиція на їх основі | |
| ATE175661T1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
| NO982778L (no) | Morfinderivater med smertestillende virkning | |
| MXPA02012470A (es) | Inhibidores de fosfodiesterasa especificos para gmp ciclico. | |
| YU47809B (sr) | Novi ergolin-8-karboksamidi i postupak za njihovo dobijanje | |
| DE59510713D1 (de) | N-substituierte 3-azabicyclo(3.2.0)heptan-derivate als neuroleptika | |
| DE69619259D1 (de) | Amidin- und isothioharnstoffderivate als inhibitoren der stickstoffoxid-synthase | |
| CA2024162A1 (en) | Benzazabicyclo carbamates as novel cholinesterase inhibitors | |
| DE60121048D1 (de) | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE | |
| DE3671890D1 (de) | Benzylaminoxidaseinhibitoren, selektiv in beziehung auf andere aminoxidasen. | |
| ES2097025T3 (es) | Oxindol 1-(n-(alcoxicarbonil))carboxamidas y 1-(n-carboxamido)carboxamidas como agentes antiinflamatorios. | |
| DE69526097D1 (de) | Bicyclische carboxamide als 5-ht1a rezeptoren liganden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |