ES2171740T3 - Produccion de tetrahidropiran-4-onas 2-sustituidas opticamente activas. - Google Patents

Produccion de tetrahidropiran-4-onas 2-sustituidas opticamente activas.

Info

Publication number
ES2171740T3
ES2171740T3 ES96938390T ES96938390T ES2171740T3 ES 2171740 T3 ES2171740 T3 ES 2171740T3 ES 96938390 T ES96938390 T ES 96938390T ES 96938390 T ES96938390 T ES 96938390T ES 2171740 T3 ES2171740 T3 ES 2171740T3
Authority
ES
Spain
Prior art keywords
pct
optically active
tetrahidropiran
onas
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938390T
Other languages
English (en)
Inventor
Robert Antony Holt
Stuart Richard Rigby
David Waterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avecia Ltd
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of ES2171740T3 publication Critical patent/ES2171740T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PUEDEN PREPARARSE TETRAHIDROPIRAN 4 OLES 2 SUSTITUIDOS OPTICAMENTE ACTIVOS O SUS ESTERES UTILIZANDO ESTERASAS O HIDROLASAS A PARTIR DE LAS CORRESPONDIENTES MEZCLAS RACEMICAS DE ESTERES O ALCOHOLES. ESTO APORTA UNA RUTA HACIA LAS CORRESPONDIENTES CETONAS OPTICAMENTE ACTIVAS. LAS MEZCLAS RACEMINCAS SON PREFERIBLES EN LA FORMA CIS. TALES MEZCLAS PUEDEN PRODUCIRSE HACIENDO REACIONAR BUT 3 ENE 1 OL CON UN ALDEHIDO EN PRESENCIA DE UN ACIDO.
ES96938390T 1995-11-23 1996-11-19 Produccion de tetrahidropiran-4-onas 2-sustituidas opticamente activas. Expired - Lifetime ES2171740T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9523924.0A GB9523924D0 (en) 1995-11-23 1995-11-23 Production of optically active 2-substituted tetrahydropyran-4-ones

Publications (1)

Publication Number Publication Date
ES2171740T3 true ES2171740T3 (es) 2002-09-16

Family

ID=10784307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938390T Expired - Lifetime ES2171740T3 (es) 1995-11-23 1996-11-19 Produccion de tetrahidropiran-4-onas 2-sustituidas opticamente activas.

Country Status (12)

Country Link
US (1) US5962282A (es)
EP (1) EP0862646B1 (es)
JP (1) JP2000500344A (es)
AT (1) ATE215603T1 (es)
AU (1) AU7583696A (es)
CA (1) CA2238172A1 (es)
DE (1) DE69620437T2 (es)
DK (1) DK0862646T3 (es)
ES (1) ES2171740T3 (es)
GB (1) GB9523924D0 (es)
PT (1) PT862646E (es)
WO (1) WO1997019185A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258574B1 (en) * 1995-11-23 2001-07-10 Zeneca Limited Production of optically active 2-substituted tetrahydropyran-4-ones
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3049403B2 (ja) * 1991-11-01 2000-06-05 チッソ株式会社 光学活性トランス−２−アリール−１−シクロヘキサノール誘導体およびその製造法
CA2118795A1 (en) * 1991-09-20 1993-04-01 John Crosby Pyranones
CA2118796A1 (en) * 1991-09-20 1993-04-01 John Crosby Pyranones

Also Published As

Publication number Publication date
AU7583696A (en) 1997-06-11
GB9523924D0 (en) 1996-01-24
US5962282A (en) 1999-10-05
EP0862646A1 (en) 1998-09-09
PT862646E (pt) 2002-09-30
CA2238172A1 (en) 1997-05-29
WO1997019185A1 (en) 1997-05-29
EP0862646B1 (en) 2002-04-03
DE69620437T2 (de) 2002-11-07
JP2000500344A (ja) 2000-01-18
DK0862646T3 (da) 2002-07-22
ATE215603T1 (de) 2002-04-15
DE69620437D1 (de) 2002-05-08

Similar Documents

Publication Publication Date Title
ATE208389T1 (de) Verfahren zur herstellung von enantiomerenreinen tropasäureestern
DE59814270D1 (de) Verfahren zur Herstellung von optisch aktiven Aminoalkoholen
ATE141278T1 (de) Diphosphonsaurederivate als zwischenprodukte zur herstellung von diphosphinliganden
DE59609824D1 (de) Verfahren zur herstellung von substituierten arylmilchsäure-haltigen cyclodepsipeptiden mit 24 ringatomen
DE69021711D1 (de) Verfahren zur Herstellung von optisch aktiven Hydroxylactonen.
ES2171740T3 (es) Produccion de tetrahidropiran-4-onas 2-sustituidas opticamente activas.
DK1129087T3 (da) Fremgangsmåde til racemisering
DE69722624D1 (de) Die bioauflösung auf n-acylazetidin-2-carbonsäuren
ATE188140T1 (de) Nichtionische emulgatoren
DE59106876D1 (de) Verfahren zur enzymatischen Herstellung optisch aktiver Cyanhydrine.
PT793666E (pt) Processo de sililacao
ATE360087T1 (de) Verfahren zur racematspaltung von arylalkylcarbonsäureestern
EA200001153A1 (ru) Очистка карбоксальдегида
ATE253125T1 (de) Verfahren zur herstellung von optisch aktiven 1- amino-4- (hydroxymethyl)- cyclopent-2- en- derivaten
DE60035494D1 (de) Verfahren zur herstellung von pseudomycin aus pseudomonas syringae
PT846111E (pt) Sintese de compostos opticamente puros uteis como inibidores da garft e seus intermediarios
ATE157655T1 (de) Verfahren zur herstellung von gegebenfalls 2- substituierten 5-chlorimidazolen
ATE202332T1 (de) Herstellung und verwendung der reinen enantiomere der 8-halogen-6-hydroxyoctansäuren, ihrer alkylester und ihrer salze mit reinen enantiomeren des alpha-methylbenzylamins
DE69620244D1 (de) Verfahren zur herstellung von prostaglandin e1
DE69818133D1 (de) Herstellung von einer optisch-aktiven Sphingoid-Verbindung

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 862646

Country of ref document: ES