DE69722624D1 - Die bioauflösung auf n-acylazetidin-2-carbonsäuren - Google Patents

Die bioauflösung auf n-acylazetidin-2-carbonsäuren

Info

Publication number
DE69722624D1
DE69722624D1 DE69722624T DE69722624T DE69722624D1 DE 69722624 D1 DE69722624 D1 DE 69722624D1 DE 69722624 T DE69722624 T DE 69722624T DE 69722624 T DE69722624 T DE 69722624T DE 69722624 D1 DE69722624 D1 DE 69722624D1
Authority
DE
Germany
Prior art keywords
acylazetidine
pct
bio
resolution
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722624T
Other languages
English (en)
Other versions
DE69722624T2 (de
Inventor
John Taylor
Simon Parratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69722624D1 publication Critical patent/DE69722624D1/de
Publication of DE69722624T2 publication Critical patent/DE69722624T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Saccharide Compounds (AREA)
DE69722624T 1996-07-15 1997-07-15 Die bioauflösung auf n-acylazetidin-2-carbonsäuren Expired - Lifetime DE69722624T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9614856 1996-07-15
GBGB9614856.4A GB9614856D0 (en) 1996-07-15 1996-07-15 New resolution method
PCT/GB1997/001916 WO1998002568A1 (en) 1996-07-15 1997-07-15 The bioresolution of n-acylazetidine-2-carboxylic acids

Publications (2)

Publication Number Publication Date
DE69722624D1 true DE69722624D1 (de) 2003-07-10
DE69722624T2 DE69722624T2 (de) 2004-04-22

Family

ID=10796945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722624T Expired - Lifetime DE69722624T2 (de) 1996-07-15 1997-07-15 Die bioauflösung auf n-acylazetidin-2-carbonsäuren

Country Status (11)

Country Link
US (1) US6136591A (de)
EP (1) EP0912755B1 (de)
JP (2) JP4189032B2 (de)
AT (1) ATE242334T1 (de)
AU (1) AU717771B2 (de)
CA (1) CA2259402A1 (de)
DE (1) DE69722624T2 (de)
GB (1) GB9614856D0 (de)
NO (1) NO990155L (de)
NZ (1) NZ333445A (de)
WO (1) WO1998002568A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9614856D0 (en) * 1996-07-15 1996-09-04 Chiroscience Ltd New resolution method
EP0855446B1 (de) 1997-01-24 2003-04-09 Sumitomo Chemical Company, Limited Verfahren zur Herstellung von optisch aktiven Azetidin-2-Carbonsäurederivaten
GB9714877D0 (en) * 1997-07-15 1997-09-17 Chiroscience Ltd Microorganism and its use
EP1201653B1 (de) * 1998-05-14 2005-04-20 Sumitomo Chemical Company, Limited Verfahren zur Racemisierung optischer aktiver Azetidin-2-Carbonsäure-Ester
JP3757629B2 (ja) * 1998-07-17 2006-03-22 住友化学株式会社 光学活性ｎ−置換アゼチジン−２−カルボン酸化合物の製造方法
SE9802939D0 (sv) 1998-09-01 1998-09-01 Astra Ab New process
JP2000344739A (ja) 1999-06-01 2000-12-12 Sumitomo Chem Co Ltd Ｎ−保護−アゼチジン−２−カルボン酸の製造方法
DE60044276D1 (de) 1999-06-04 2010-06-10 Sumitomo Chemical Co Esterase Gene und Verwendungen davon
KR100378741B1 (ko) * 2000-06-01 2003-04-07 에스케이 주식회사 효소를 이용하여 R-폼 또는 S-폼의 α-치환 헤테로싸이클릭 카르복실산 및 이와 상반되는 광학특성을 갖는 α-치환 헤테로싸이클릭 카르복실산 에스테르를 제조하는 방법
CA2410438A1 (en) * 2000-06-01 2001-12-06 Sk Corporation Method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid using enzyme
KR20030012964A (ko) * 2001-08-06 2003-02-14 주식회사 제노포커스 광학활성 α-치환 헤테로시클릭카르복실산 에스테르의제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692909B1 (fr) * 1992-06-24 1995-07-21 Irceba Procede de preparation d'aryl-1 alcanols substitues optiquement purs.
GB9614856D0 (en) * 1996-07-15 1996-09-04 Chiroscience Ltd New resolution method

Also Published As

Publication number Publication date
EP0912755A1 (de) 1999-05-06
AU3699597A (en) 1998-02-09
US6136591A (en) 2000-10-24
ATE242334T1 (de) 2003-06-15
NO990155L (no) 1999-03-15
WO1998002568A1 (en) 1998-01-22
NZ333445A (en) 2000-06-23
JP4189032B2 (ja) 2008-12-03
DE69722624T2 (de) 2004-04-22
AU717771B2 (en) 2000-03-30
JP2009022270A (ja) 2009-02-05
EP0912755B1 (de) 2003-06-04
GB9614856D0 (en) 1996-09-04
CA2259402A1 (en) 1998-01-22
JP2000515371A (ja) 2000-11-21
NO990155D0 (no) 1999-01-14

Similar Documents

Publication Publication Date Title
DE69722624D1 (de) Die bioauflösung auf n-acylazetidin-2-carbonsäuren
YU99092A (sh) Organske soli n,n'-diacetilcistina i postupak za njihovo dobijanje
FI944119A0 (fi) Entsymaattinen menetelmä synteettisen esterin valmistamiseksi kasviöljystä
DK0535940T3 (da) Fremgangsmåde til fremstilling af dihomo-gamma-linolensyre og et lipid indeholdende samme
PT89553A (pt) Processo de preparacao de acidos 2-arilpropionicos opticamente activos
DE69527617T2 (de) Verfahren zur racematspaltung von etodolac unter verwendung von glucamin-derivaten
DK0535939T3 (da) Fremgangsmåde til fremstilling af omega 9-type polyumættet fedtsyre
ATE258604T1 (de) Verfahren zur enzymatischen auflösung von laktamen
GR3008107T3 (de)
ES2167008T3 (es) Procedimiento de produccion de derivados de diol-1,3 naturales y de derivados de 1,3-dioxano naturales correspondientes.
ES2046950A1 (es) Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil)propionico por hidrolisis enantioselectiva catalizada enzimaticamente.
NO990159L (no) FremgangsmÕte for fremstilling av enantiomerisk anrikede N-acylazetidin-2-karboksylsyrer
GB9523924D0 (en) Production of optically active 2-substituted tetrahydropyran-4-ones
YU25996A (sh) Enzimatska hidroliza 3,3-dietil-4-/(4-karboksi) fenoksi/-2-azetidinon estara
ES2055122T3 (es) Procedimiento de preparacion de acidos 2-ariloxi- o 2-ariltio-alcanoicos.
NO930546D0 (no) Fremgangsmaate for omdanning av 2(3-benzoylfenyl)propionsyre til en s(+)isomer
DK0407909T3 (da) Fremgangsmåde til fremstilling af R-(+)-3-oxocycloalkancarboxylsyrer
ES2133384T3 (es) Procedimiento para la oxidacion enzimatica de acidos (d)-2-hidroxicarboxilicos para dar acidos 2-cetocarboxilicos.
FR2737644B1 (fr) Procede d'extraction proteique par hydrolyse enzymatique
MY108716A (en) New isobutyl-substituted methanesulphonyl-quinolyl- mehtoxyphenyl- cycloalkylacetamides.
DE59108272D1 (de) Verfahren zur racemisierung von nichtracemischen 3-oxocyclopentan- bzw. -hexancarbonsäuren oder ihren estern mit c 1-c 6-alkoholen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition