ES2171156T3 - Produccion de vacunas por ingenieria genetica para sida y otras enfermedades retroviricas. - Google Patents
Produccion de vacunas por ingenieria genetica para sida y otras enfermedades retroviricas.Info
- Publication number
- ES2171156T3 ES2171156T3 ES90914669T ES90914669T ES2171156T3 ES 2171156 T3 ES2171156 T3 ES 2171156T3 ES 90914669 T ES90914669 T ES 90914669T ES 90914669 T ES90914669 T ES 90914669T ES 2171156 T3 ES2171156 T3 ES 2171156T3
- Authority
- ES
- Spain
- Prior art keywords
- genetic engineering
- aids
- retrovirical
- diseases
- vaccine production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000030507 AIDS Diseases 0.000 title abstract 2
- 238000010353 genetic engineering Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000009746 Adult T-Cell Leukemia-Lymphoma Diseases 0.000 abstract 1
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 abstract 1
- 206010038997 Retroviral infections Diseases 0.000 abstract 1
- 201000011176 T-cell adult acute lymphocytic leukemia Diseases 0.000 abstract 1
- 206010042987 T-cell type acute leukaemia Diseases 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000001524 infective effect Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/974—Aids related test
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/802—Virus-based particle
- Y10S977/803—Containing biological material in its interior
- Y10S977/804—Containing nucleic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/917—Vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/918—Immunological
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/92—Detection of biochemical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UNA PARTICULA, TIPO-RETROVIRUS, INMUNOGENICA QUE NO ES INFECCIOSA Y QUE ES UTIL COMO COMPONENTE CANDIDATO A UNA VACUNA PARA LAS INFECCIONES RETROVIRALES, INCLUYENDO EL SIDA Y ATLL, SE PRODUCE MEDIANTE INGENIERIA GENETICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898923123A GB8923123D0 (en) | 1989-10-13 | 1989-10-13 | A vaccine for human immunodeficiency virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2171156T3 true ES2171156T3 (es) | 2002-09-01 |
Family
ID=10664542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90914669T Expired - Lifetime ES2171156T3 (es) | 1989-10-13 | 1990-10-12 | Produccion de vacunas por ingenieria genetica para sida y otras enfermedades retroviricas. |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US5439809A (es) |
| EP (1) | EP0495811B1 (es) |
| JP (1) | JP2537570B2 (es) |
| AT (1) | ATE211766T1 (es) |
| CA (1) | CA2067333C (es) |
| DE (1) | DE69033896T2 (es) |
| DK (1) | DK0495811T3 (es) |
| ES (1) | ES2171156T3 (es) |
| GB (1) | GB8923123D0 (es) |
| WO (1) | WO1991005864A1 (es) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861282A (en) * | 1989-10-16 | 1999-01-19 | Whitehead Institute For Biomedical Research | Non-infectious HIV particles and uses therefor |
| ZA909302B (en) * | 1989-11-20 | 1991-09-25 | Oncogen | Nonreplicating recombinant-made retroviral particles useful as anti-viral agents and as immunogens for prophylaxis and therapy against human retroviruses |
| WO1991019803A1 (en) * | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Self assembled, defective, nonself-propagating viral particles |
| IL98845A0 (en) * | 1990-07-19 | 1992-07-15 | Merck & Co Inc | Coconjugate vaccines comprising immunogenic protein,hiv related peptides,and anionic moieties,their preparation and pharmaceutical compositions containing them |
| US5866137A (en) * | 1990-10-12 | 1999-02-02 | Benjamin Rovinski | Self-assembled, non-infectious, non-replicating; immunogenic retrovirus-like particles comprising modified HIV genomes devoid of long terminal repeats and chimeric envelope glycoproteins |
| AU702634B2 (en) * | 1991-03-07 | 1999-02-25 | Virogenetics Corporation | Immunodeficiency recombinant poxvirus |
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| FR2676071B1 (fr) * | 1991-05-02 | 1994-11-18 | Transgene Sa | Nouveau variant gp160 non-clivable, soluble, de forme hybride. |
| JPH07500490A (ja) * | 1991-05-15 | 1995-01-19 | ランスティチュ ドュ レシェルシュ クリニーク ドュ モントリオール | 非感染性hivゲノムを保持するトランスジェニック非ヒト動物 |
| US6268211B1 (en) | 1991-08-20 | 2001-07-31 | L'institut De Recherches Cliniques De Montreal | Non-infectious HIV transgene |
| US5274122A (en) * | 1992-10-15 | 1993-12-28 | Merck & Co., Inc. | Acidic derivatives of homocysteine thiolactone |
| DE69430646T2 (de) * | 1993-02-17 | 2003-01-02 | Wisconsin Alumni Research Foundation, Madison | Retroviren vom Typ "more-complex", die LTR von gemischtem Typ enthalten und deren Anwendungen |
| US5470572A (en) * | 1993-07-16 | 1995-11-28 | University Of Puerto Rico | Non-infectious simian immunodeficiency virus particles produced by cell line CRL 11393 |
| WO1995005851A1 (en) * | 1993-08-20 | 1995-03-02 | St. Luke's-Roosevelt Hospital Center | HIV vif-RELATED COMPOSITIONS, AND PROPHYLACTIC AND THERAPEUTIC USES THEREOF |
| US6015661A (en) * | 1994-02-14 | 2000-01-18 | The Macfarlane Burnet Centre For Medical Research Limited | Methods for the detection of non-pathogenic HIV-1 strains containing deletions in the Nef coding region and U3 region of the LTR |
| US6291157B1 (en) | 1998-02-23 | 2001-09-18 | Connaught Laboratories Limited | Antigenically-marked non-infectious retrovirus-like particles |
| US5955342A (en) * | 1994-08-15 | 1999-09-21 | Connaught Laboratories Limited | Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region |
| US5858838A (en) | 1998-02-23 | 1999-01-12 | Taiwan Semiconductor Manufacturing Company, Ltd. | Method for increasing DRAM capacitance via use of a roughened surface bottom capacitor plate |
| US6080408A (en) * | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
| WO1996014855A1 (en) * | 1994-11-15 | 1996-05-23 | Agracetus, Inc. | Method for inducing humoral and cellular immune responses utilizing intracellular delivery of peptide-coated microparticles |
| WO1996030523A2 (en) * | 1995-03-31 | 1996-10-03 | Hans Wolf | Antigen presentation system based on retrovirus-like particles |
| IL125464A (en) * | 1996-01-29 | 2007-12-03 | Virologic Inc | Preparations and methods for determining susceptibility and resistance to antiviral drugs and filtering antiviral drugs |
| US6242187B1 (en) * | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| US6024965A (en) * | 1996-10-18 | 2000-02-15 | Erasums University Rotterdam | Induction of REV and TAT specific cytotoxic T-cells for prevention and treatment of human immunodeficiency virus (HIV) infection |
| WO1998043669A1 (en) * | 1997-04-03 | 1998-10-08 | Thomas Jefferson University | Chimeric viral proteins |
| KR100314142B1 (ko) * | 1997-08-07 | 2002-06-22 | 김기태 | 재조합사빈1형폴리오바이러스벡터 |
| US20050033022A1 (en) * | 1997-09-26 | 2005-02-10 | Smithkline Beecham Biologicals Sa | Fusion proteins comprising HIV-1 Tat and/or Nef proteins |
| US6121021A (en) | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
| FI105105B (fi) * | 1998-02-27 | 2000-06-15 | Finnish Immunotechnology Ltd O | Itsereplikoiva DNA-vektori immunisoimiseksi HIV:ta vastaan |
| US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| WO1999058726A1 (en) | 1998-05-12 | 1999-11-18 | Genecure Llc | Replication defective hiv vaccine |
| US7090848B1 (en) * | 1998-08-04 | 2006-08-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | HIV-1 envelope protein associated with a broadly reactive neutralizing antibody response |
| WO2000007631A1 (en) * | 1998-08-04 | 2000-02-17 | The Henry M. Jackson Foundation | Expression and characterization of hiv-1 envelope protein associated with a broadly reactive neutralizing antibody response |
| US6764676B1 (en) | 1998-08-24 | 2004-07-20 | Pfizer Inc. | Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus |
| EP1418940A4 (en) | 2000-03-02 | 2006-09-20 | Univ Emory | DNA EXPRESSION VECTORS AND METHODS OF USE |
| US8623379B2 (en) * | 2000-03-02 | 2014-01-07 | Emory University | Compositions and methods for generating an immune response |
| US20040105871A1 (en) * | 2000-03-02 | 2004-06-03 | Robinson Harriet L. | Compositions and methods for generating an immune response |
| DK1280551T3 (da) * | 2000-04-27 | 2007-05-21 | Sanofi Pasteur Ltd | Vacciner mod HIV-infektion |
| EP1776961A1 (en) * | 2000-04-27 | 2007-04-25 | Sanofi Pasteur Limited | Immunizing against HIV infection |
| US6585978B1 (en) * | 2000-09-09 | 2003-07-01 | Akzo Nobel | EIA vaccine and diagnostic |
| US6461616B1 (en) * | 2000-09-09 | 2002-10-08 | Akzo Nobel Nv | EIAV p26 deletion vaccine and diagnostic |
| US7122180B2 (en) * | 2000-10-23 | 2006-10-17 | Children's Medical Center Corporation | DNA vectors containing mutated HIV proviruses |
| PT1372710E (pt) * | 2001-03-08 | 2009-12-21 | Us Gov Health & Human Serv | Vam modificado que expressa os genes gag e pol do envelope de vih |
| FR2824072B1 (fr) * | 2001-04-27 | 2004-03-12 | Centre Nat Rech Scient | Procede de replication et de production du virus de l'hepatite c |
| US7943146B2 (en) * | 2001-12-21 | 2011-05-17 | Myrexis, Inc. | Immunizing compositions comprising HIV-1 proviral constructs with an inactive p6 gag TSG101 UEV binding domain capable of producing budding-defective viral particles that remain tethered to the cell surface |
| WO2004065575A2 (en) * | 2003-01-15 | 2004-08-05 | Research Institute For Genetic And Human Therapy (Right) | Dna compositon and uses thereof |
| AU2004270275B2 (en) * | 2003-09-09 | 2010-02-18 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to HIV humans |
| US20050222068A1 (en) | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
| US20070135620A1 (en) * | 2004-11-12 | 2007-06-14 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8367805B2 (en) * | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| US20090239215A1 (en) * | 2004-12-16 | 2009-09-24 | Brandeis University | Clonable Tag for Purification and Electron Microscopy Labeling |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| WO2009049351A1 (en) * | 2007-10-15 | 2009-04-23 | The University Of Queensland | Construct system and uses therefor |
| US12492253B1 (en) | 2008-02-25 | 2025-12-09 | Xencor, Inc. | Anti-human C5 antibodies |
| AU2009335740B2 (en) | 2008-12-17 | 2016-04-21 | Sarepta Therapeutics, Inc. | Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
| US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
| BR112013025481B8 (pt) | 2011-04-06 | 2022-11-08 | Univ Paris Descartes | Composições farmacêuticas, uso destas e kits para prevenir e/ou tratar uma doença por hiv em humanos |
| SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| US9249191B2 (en) | 2012-02-16 | 2016-02-02 | Vlp Therapeutics, Llc | Virus like particle composition |
| EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
| US9730996B2 (en) * | 2012-10-24 | 2017-08-15 | Texas Biomedical Research Institute | Involucrin-driven retroviral expression cassettes encoding human immunodeficiency virus envelope glycoproteins |
| US9637532B2 (en) * | 2013-07-12 | 2017-05-02 | Vlp Therapeutics, Llc | Virus like particle comprising PD-1 antigen or PD-1 ligand antigen |
| EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US10385101B2 (en) | 2014-08-08 | 2019-08-20 | Vlp Therapeutics, Llc | Virus like particle comprising modified envelope protein E3 |
| CN106795513B (zh) | 2014-08-08 | 2021-06-11 | Vlp治疗公司 | 包含修饰的包膜蛋白e3的病毒样颗粒 |
| MX383330B (es) | 2014-09-11 | 2025-03-13 | Vlp Therapeutics Inc | Particula tipo virus de flavivirus. |
| EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| EP3386593A4 (en) | 2015-12-09 | 2019-07-24 | Admedus Vaccines Pty Ltd | IMMUNOMODULATING COMPOSITION FOR TREATMENT |
| CN120607606A (zh) | 2017-08-22 | 2025-09-09 | 莫纳施大学 | 渐进性糖化终极产物受体(rage)活化的筛选测定法、调节物和调节 |
| CA3074088A1 (en) * | 2017-09-01 | 2019-03-07 | Inprother Aps | A vaccine for use in the prophylaxis and/or treatment of a disease |
| KR102823029B1 (ko) | 2017-12-20 | 2025-06-20 | 브이엘피 테라퓨틱스 인코포레이티드 | 알파바이러스 레플리콘 입자 |
| WO2020257309A1 (en) * | 2019-06-17 | 2020-12-24 | Enochian BioPharma, Inc. | Allogeneic t-cell-based hiv vaccine to induce cellular and humoral immunity |
| EP4135847A4 (en) | 2020-04-17 | 2024-05-15 | VLP Therapeutics, Inc. | Coronavirus vaccine |
| CN115552009A (zh) | 2020-04-30 | 2022-12-30 | Vlp治疗公司 | 细胞因子免疫疗法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59104325A (ja) * | 1982-12-07 | 1984-06-16 | Japan Found Cancer | ヒト白血病ウイルスの遺伝子rnaに相補性を示すdna |
| US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| ZA867281B (en) * | 1985-09-25 | 1987-05-27 | Oncogen | Vaccines and immunoassays for acquired immune deficiency syndrome |
| NZ217645A (en) * | 1985-09-25 | 1991-11-26 | Oncogen | Recombinant viruses expressing lav/htlv-iii related epitopes and vaccine formulations |
| US4925784A (en) * | 1986-04-04 | 1990-05-15 | Hoffmann-La Roche Inc. | Expression and purification of an HTLV-III gag/env gene protein |
| US4752565A (en) * | 1986-04-07 | 1988-06-21 | The United States Of America As Represented By The Department Of Health And Human Services | Cell line producing AIDS viral antigens without producing infectious virus particles |
| EP0329671B1 (en) * | 1986-11-01 | 1994-01-12 | British Bio-Technology Limited | Particulate hybrid hiv antigens |
| JPH01120284A (ja) * | 1987-11-05 | 1989-05-12 | Shiro Kato | Hiv不完全粒子および該製造方法 |
| IL89567A0 (en) * | 1988-03-28 | 1989-09-10 | Univ Leland Stanford Junior | Mutated hiv envelope protein |
| WO1989012095A1 (en) * | 1988-06-10 | 1989-12-14 | Applied Biotechnology, Inc. | A method of evaluating recombinant vaccines against immunodeficiency virus |
| US5019752A (en) | 1988-06-16 | 1991-05-28 | Hughes Aircraft Company | Plasma switch with chrome, perturbated cold cathode |
| JPH02203783A (ja) * | 1989-02-02 | 1990-08-13 | Banyu Pharmaceut Co Ltd | 抗原性を有する非感染性エイズウイルス産生クローン化ヒトt細胞 |
| JP3140757B2 (ja) * | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
| WO1990015141A2 (en) * | 1989-06-01 | 1990-12-13 | Applied Biotechnology, Inc. | Self-assembled, defective, non-self-propagating viral particles |
| JP2897295B2 (ja) * | 1989-12-14 | 1999-05-31 | 味の素株式会社 | レトロウィルス高生産用dna構築物及びレトロウィルス高生産用細胞株 |
| WO1991019803A1 (en) * | 1990-06-19 | 1991-12-26 | Applied Biotechnology, Incorporated | Self assembled, defective, nonself-propagating viral particles |
-
1989
- 1989-10-13 GB GB898923123A patent/GB8923123D0/en active Pending
-
1990
- 1990-10-12 JP JP2513524A patent/JP2537570B2/ja not_active Expired - Lifetime
- 1990-10-12 WO PCT/CA1990/000350 patent/WO1991005864A1/en not_active Ceased
- 1990-10-12 ES ES90914669T patent/ES2171156T3/es not_active Expired - Lifetime
- 1990-10-12 EP EP90914669A patent/EP0495811B1/en not_active Expired - Lifetime
- 1990-10-12 DE DE69033896T patent/DE69033896T2/de not_active Expired - Lifetime
- 1990-10-12 CA CA002067333A patent/CA2067333C/en not_active Expired - Lifetime
- 1990-10-12 DK DK90914669T patent/DK0495811T3/da active
- 1990-10-12 AT AT90914669T patent/ATE211766T1/de not_active IP Right Cessation
-
1992
- 1992-06-15 US US07/839,751 patent/US5439809A/en not_active Expired - Lifetime
-
1994
- 1994-05-06 US US08/239,427 patent/US5571712A/en not_active Expired - Lifetime
-
1995
- 1995-03-09 US US08/401,355 patent/US6291227B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/467,975 patent/US5985641A/en not_active Expired - Lifetime
-
1999
- 1999-09-03 US US09/389,364 patent/US7008784B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE211766T1 (de) | 2002-01-15 |
| EP0495811A1 (en) | 1992-07-29 |
| US5439809A (en) | 1995-08-08 |
| JPH04506301A (ja) | 1992-11-05 |
| US5571712A (en) | 1996-11-05 |
| JP2537570B2 (ja) | 1996-09-25 |
| US6291227B1 (en) | 2001-09-18 |
| DK0495811T3 (da) | 2002-02-11 |
| DE69033896D1 (de) | 2002-02-14 |
| CA2067333A1 (en) | 1991-04-14 |
| WO1991005864A1 (en) | 1991-05-02 |
| GB8923123D0 (en) | 1989-11-29 |
| US5985641A (en) | 1999-11-16 |
| EP0495811B1 (en) | 2002-01-09 |
| DE69033896T2 (de) | 2002-11-14 |
| US7008784B1 (en) | 2006-03-07 |
| CA2067333C (en) | 2001-05-01 |
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