ES2170288T3 - Metodo y aparato para fabricar capsulas farmaceuticas de celulosa, con secado de la capsula. - Google Patents

Metodo y aparato para fabricar capsulas farmaceuticas de celulosa, con secado de la capsula.

Info

Publication number
ES2170288T3
ES2170288T3 ES97100246T ES97100246T ES2170288T3 ES 2170288 T3 ES2170288 T3 ES 2170288T3 ES 97100246 T ES97100246 T ES 97100246T ES 97100246 T ES97100246 T ES 97100246T ES 2170288 T3 ES2170288 T3 ES 2170288T3
Authority
ES
Spain
Prior art keywords
capsule
pins
solution
drying
manufacturing pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97100246T
Other languages
English (en)
Inventor
Ralph R Grosswald
Jeffory B Anderson
Clair S Andrew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RP Scherer Technologies LLC
Original Assignee
RP Scherer Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RP Scherer Technologies LLC filed Critical RP Scherer Technologies LLC
Application granted granted Critical
Publication of ES2170288T3 publication Critical patent/ES2170288T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/02—Moulds or cores; Details thereof or accessories therefor with incorporated heating or cooling means
    • B29C33/06—Moulds or cores; Details thereof or accessories therefor with incorporated heating or cooling means using radiation, e.g. electro-magnetic waves, induction heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/30—Mounting, exchanging or centering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/0277—Apparatus with continuous transport of the material to be cured
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/04—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/14—Dipping a core
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/34—Moulds or cores; Details thereof or accessories therefor movable, e.g. to or from the moulding station
    • B29C33/36—Moulds or cores; Details thereof or accessories therefor movable, e.g. to or from the moulding station continuously movable in one direction, e.g. in a closed circuit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/44—Moulds or cores; Details thereof or accessories therefor with means for, or specially constructed to facilitate, the removal of articles, e.g. of undercut articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/56—Coatings, e.g. enameled or galvanised; Releasing, lubricating or separating agents
    • B29C33/60—Releasing, lubricating or separating agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/04—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam
    • B29C35/045—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould using liquids, gas or steam using gas or flames
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0805—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2001/00—Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Manufacturing & Machinery (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

METODO Y APARATO PARA FABRICAR CAPSULAS FARMACEUTICAS QUE UTILIZAN UNA SOLUCION ACUOSA DE UNA COMPOSICION DE ETER DE CELULOSA TERMOGELIFICANTE Y LA UTILIZACION DE CLAVIJAS DE CUERPO DE CAPSULA Y CLAVIJAS DE FORRO DE CAPSULA COMO MOLDES. EL METODO SUPONE EL CALENTAMIENTO DE LAS CLAVIJAS, EL SUMERGIDO DE LAS MISMAS EN LA SOLUCION PARA HACER QUE ESTA GELATINICE SOBRE LA SUPERFICIE DE LAS CLAVIJAS, LA RETIRADA DE LAS CLAVIJAS Y EL SECADO DE LA SOLUCION GELATINIZADA SOBRE LA SUPERFICIE DE LAS CLAVIJAS PARA FORMAR CUERPOS DE CAPSULA Y FORROS DE CAPSULA. SE APLICA AIRE A CONTRACORRIENTE PARA FACILITAR EL SECADO DESDE EL INTERIOR Y LA INVENCION PROPORCIONA AIRE HUMEDO PARA RETRASAR LA TASA DE SECADO Y EVITAR LA FORMACION DE DEFECTOS EN LA CAPSULA. LA INVENCION TAMBIEN INCLUYE EL SECADO INDIRECTO DE LAS CAPSULAS MEDIANTE CALOR RADIACTIVO Y EL SECADO DIRECTO MEDIANTE EL CALENTAMIENTO DE LAS CLAVIJAS.
ES97100246T 1991-05-31 1992-05-29 Metodo y aparato para fabricar capsulas farmaceuticas de celulosa, con secado de la capsula. Expired - Lifetime ES2170288T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70802391A 1991-05-31 1991-05-31

Publications (1)

Publication Number Publication Date
ES2170288T3 true ES2170288T3 (es) 2002-08-01

Family

ID=24844076

Family Applications (3)

Application Number Title Priority Date Filing Date
ES97100247T Expired - Lifetime ES2181935T3 (es) 1991-05-31 1992-05-29 Metodo y aparato para fabricar capsulas farmaceuticas de celulosa- dimensionamiento la capsula.
ES97100246T Expired - Lifetime ES2170288T3 (es) 1991-05-31 1992-05-29 Metodo y aparato para fabricar capsulas farmaceuticas de celulosa, con secado de la capsula.
ES97100248T Expired - Lifetime ES2143259T3 (es) 1991-05-31 1992-05-29 Metodo y aparato para la fabricacion de capsulas farmaceuticas de celulosa totalmente gelatinizantes.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES97100247T Expired - Lifetime ES2181935T3 (es) 1991-05-31 1992-05-29 Metodo y aparato para fabricar capsulas farmaceuticas de celulosa- dimensionamiento la capsula.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97100248T Expired - Lifetime ES2143259T3 (es) 1991-05-31 1992-05-29 Metodo y aparato para la fabricacion de capsulas farmaceuticas de celulosa totalmente gelatinizantes.

Country Status (12)

Country Link
EP (5) EP0784969A2 (es)
JP (1) JP3299744B2 (es)
AT (4) ATE213147T1 (es)
AU (1) AU2159892A (es)
CA (1) CA2108768A1 (es)
DE (4) DE69221300D1 (es)
DK (2) DK0781542T3 (es)
ES (3) ES2181935T3 (es)
LV (1) LV12557B (es)
RO (1) RO118521B1 (es)
SG (1) SG46227A1 (es)
WO (1) WO1992021311A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
DK106293D0 (da) * 1993-09-22 1993-09-22 Joergen Rasmussen Kapsel til indbringning af laegemidler i kreaturmaver
US5993185A (en) * 1996-03-21 1999-11-30 Farmacapsulas S.A. Deck plate assemblies for forming capsules
US5945136A (en) * 1997-04-03 1999-08-31 Technophar Equipment & Service Limited Heating elevator for capsule making machine
US6000928A (en) * 1997-04-03 1999-12-14 Technophar Equipment & Service Limited Capsule making machine having improved pin bars and air flow characteristics
KR100661918B1 (ko) * 1999-04-01 2006-12-28 다우 글로벌 테크놀로지스 인크. 겔 강도가 증가된 메틸셀룰로스, 이의 제조방법 및 이를 포함하는 식품 조성물
US6306333B1 (en) * 1999-06-24 2001-10-23 The Dow Chemical Company Process for making cellulose ethers having reduced yellowing and discoloration
JP4634796B2 (ja) * 2002-06-24 2011-02-16 中外製薬株式会社 非球形シームレスカプセルの製造装置
GB0314832D0 (en) * 2003-06-25 2003-07-30 Phoqus Pharmaceuticals Ltd Production of capsule shells and capsules
EP2083786B1 (en) * 2006-10-26 2011-01-12 Pfizer Products Inc. Capsule formation
WO2012029887A1 (ja) * 2010-08-31 2012-03-08 独立行政法人農業生物資源研究所 筒状構成物及びその製造方法
US20140150787A1 (en) 2012-12-04 2014-06-05 Civitas Therapeutics, Inc. Devices and methods for puncturing a capsule to release a powdered medicament therefrom
CN103202767B (zh) * 2013-03-22 2014-07-02 新昌县祥瑞机械设备有限公司 胶板翻转装置
CN103482341B (zh) * 2013-09-26 2015-08-26 新昌县宏海机械有限公司 一种胶板输送翻板一体化设备
WO2016157213A2 (en) * 2015-03-28 2016-10-06 Anand Goldie Capsule gripping system
CN104786411B (zh) * 2015-04-29 2017-04-19 青岛微恒工程有限公司 一种伺服蘸胶装置
CN105596215B (zh) * 2015-12-30 2019-02-15 新昌县捷奥激光制品有限公司 一种胶囊的打孔设备
EP3719429A4 (en) 2017-12-06 2021-09-08 Qualicaps Co., Ltd. DRYING DEVICE FOR PILLAR STRUCTURE AND METHOD FOR MANUFACTURING A PILLAR-SHAPED STRUCTURE
CN111251521B (zh) * 2018-12-03 2022-07-22 沈欣 液态珠丸的制造方法

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US1787777A (en) 1926-12-10 1931-01-06 Parke Davis & Co Capsule machine
US1978829A (en) 1930-07-21 1934-10-30 Parke Davis & Co Method and apparatus for drying capsules
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US2869178A (en) * 1953-12-07 1959-01-20 Scherer Corp R P Machine for making hard-shell gelatine capsules
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US3617588A (en) 1969-06-16 1971-11-02 Dow Chemical Co Dip-coating process for preparing cellulose ether capsule shells
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US3664495A (en) 1970-12-21 1972-05-23 Parke Davis & Co Locking capsule
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DE2259387C2 (de) * 1972-12-05 1981-11-26 Kupferberg-Odle, geb. Kupferberg, Murielle, 8011 Vaterstetten Verfahren zum Herstellen von Steckkapseln mit zusätzlicher Beschichtung
US3842242A (en) 1974-02-01 1974-10-15 Dow Chemical Co Apparatus for heating capsule forming pins
US4001211A (en) 1974-12-02 1977-01-04 The Dow Chemical Company Pharmaceutical capsules from improved thermogelling methyl cellulose ethers
DE2722806C2 (de) 1977-05-20 1984-12-13 Capsugel AG, Basel Kapselkörper für eine Steckkapsel für Arzneimittel oder andere portionsweise zu verpackende Stoffe, sowie Verfahren zu seiner Herstellung
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US4705658A (en) 1986-04-07 1987-11-10 Capsule Technology International, Ltd. Method for drying gelatin in the manufacture of hard shell gelatin capsules
KR900000254B1 (ko) 1986-05-12 1990-01-24 신에쯔까 가가꾸 고우교우 가부시끼가이샤 의약용 경질 캅셀의 제조방법과 그 제조장치
US4997359A (en) 1989-07-17 1991-03-05 Warner-Lambert Company Multi-well dish for capsule making

Also Published As

Publication number Publication date
RO118521B1 (ro) 2003-06-30
ATE225640T1 (de) 2002-10-15
EP0781541B1 (en) 2002-10-09
EP0781540B1 (en) 2002-02-13
JPH06508051A (ja) 1994-09-14
ATE190221T1 (de) 2000-03-15
LV12557A (en) 2000-11-20
DE69230770T2 (de) 2000-08-10
EP0587773B1 (en) 1997-07-30
SG46227A1 (en) 1998-02-20
CA2108768A1 (en) 1992-12-01
EP0781540A3 (en) 1997-07-16
EP0784969A2 (en) 1997-07-23
JP3299744B2 (ja) 2002-07-08
EP0781542B1 (en) 2000-03-08
ES2143259T3 (es) 2000-05-01
EP0781541A2 (en) 1997-07-02
DK0781540T3 (da) 2002-05-27
ES2181935T3 (es) 2003-03-01
EP0781540A2 (en) 1997-07-02
WO1992021311A1 (en) 1992-12-10
EP0781541A3 (en) 1997-07-16
DE69221300D1 (de) 1997-09-04
EP0781542A2 (en) 1997-07-02
DE69232809D1 (de) 2002-11-14
DK0781542T3 (da) 2000-07-17
EP0781542A3 (en) 1997-07-16
DE69232423T2 (de) 2002-10-10
EP0587773A1 (en) 1994-03-23
AU2159892A (en) 1993-01-08
DE69232809T2 (de) 2003-06-18
DE69232423D1 (de) 2002-03-21
DE69230770D1 (de) 2000-04-13
LV12557B (en) 2001-02-20
ATE156003T1 (de) 1997-08-15
ATE213147T1 (de) 2002-02-15

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