ES2052863T3 - Azolilmetilcarbinoles sustituidos por ciclopropilo, procedimiento para su preparacion y su uso como medicamento. - Google Patents

Azolilmetilcarbinoles sustituidos por ciclopropilo, procedimiento para su preparacion y su uso como medicamento.

Info

Publication number
ES2052863T3
ES2052863T3 ES89120575T ES89120575T ES2052863T3 ES 2052863 T3 ES2052863 T3 ES 2052863T3 ES 89120575 T ES89120575 T ES 89120575T ES 89120575 T ES89120575 T ES 89120575T ES 2052863 T3 ES2052863 T3 ES 2052863T3
Authority
ES
Spain
Prior art keywords
preparation
cyclopropil
carbinoles
replaced
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89120575T
Other languages
English (en)
Inventor
Burkhard Dr Fugmann
Manfred Dr Plempel
Klaus Dr Stroech
Karl Heinz Prof Dr Buchel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2052863T3 publication Critical patent/ES2052863T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE A UN NUEVO DERIVADO DE 1-CIANOCICLOPROPILO Y 1-CARBOXAMIDO-CICLOPROPILO-AZOLILMETILOCARBINOL; TRATA DEL PROCEDIMIENTO PARA LA PRODUCCION DEL DERIVADO Y DESCRIBE SU APLICACION COMO MEDICAMENTO PARA EL TRATAMIENTO DE LA MICOSIS.
ES89120575T 1988-11-19 1989-11-07 Azolilmetilcarbinoles sustituidos por ciclopropilo, procedimiento para su preparacion y su uso como medicamento. Expired - Lifetime ES2052863T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3839170A DE3839170A1 (de) 1988-11-19 1988-11-19 Cyclopropyl-substituierte azolylmethylcarbinole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2052863T3 true ES2052863T3 (es) 1994-07-16

Family

ID=6367500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89120575T Expired - Lifetime ES2052863T3 (es) 1988-11-19 1989-11-07 Azolilmetilcarbinoles sustituidos por ciclopropilo, procedimiento para su preparacion y su uso como medicamento.

Country Status (9)

Country Link
US (1) US5059615A (es)
EP (1) EP0370300B1 (es)
JP (1) JP2839161B2 (es)
KR (1) KR0128662B1 (es)
AT (1) ATE103907T1 (es)
CA (1) CA2003213C (es)
DE (2) DE3839170A1 (es)
ES (1) ES2052863T3 (es)
ZA (1) ZA898775B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4206529A1 (de) * 1992-03-02 1993-09-09 Bayer Ag Azolylmethyl-cyclopropyl-derivate
CN106632107A (zh) * 2012-12-19 2017-05-10 巴斯夫欧洲公司 取代[1,2,4]三唑及其作为杀真菌剂的用途
AR100743A1 (es) * 2014-06-06 2016-10-26 Basf Se Compuestos de [1,2,4]triazol sustituido
CA2955090A1 (en) * 2014-07-18 2016-01-21 Bayer Cropscience Aktiengesellschaft Substituted vinyl and alkynyl cyanocycloalkanols and vinyl and alkynyl cyanoheterocycloalkanols as active agents against abiotic plant stress
AR101214A1 (es) 2014-07-22 2016-11-30 Bayer Cropscience Ag Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas
RS58961B1 (sr) 2015-01-22 2019-08-30 Sanofi Aventis Deutschland Proces proizvodnje 2-[4-(ciklopropankarbonil)fenil]-2-metil-propannitrila
TWI636049B (zh) * 2015-11-17 2018-09-21 美商維愛美製藥公司 製備４－（（６－（２－（２，４－二氟苯基）－１，１－二氟－２－羥基－３－（１ｈ－１，２，４－三唑－１－基）丙基）吡啶－３－基）氧基）苄腈之方法
CA3005743A1 (en) * 2015-11-17 2017-05-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3378764D1 (en) * 1982-09-30 1989-02-02 Pfizer Ltd Triazole anti-fungal agents
EP0180850A3 (de) * 1984-11-02 1987-05-27 Bayer Ag Antimykotische Azolylmethyl-cyclopropyl-carbinol Derivate
US4859232A (en) * 1986-12-05 1989-08-22 Monsanto Company Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes
DE3732385A1 (de) * 1987-09-25 1989-04-06 Bayer Ag Hydroxyalkylcyclopropyl1-1,2,4-triazolyl- oder -imidazolyl-derivate und ihre verwendung als antimykotische mittel
JP2681648B2 (ja) * 1988-03-29 1997-11-26 富山化学工業株式会社 新規な２−アゾリル−１−シクロプロピルエタノール誘導体およびその塩

Also Published As

Publication number Publication date
EP0370300B1 (de) 1994-04-06
ATE103907T1 (de) 1994-04-15
DE3839170A1 (de) 1990-05-31
EP0370300A2 (de) 1990-05-30
KR900007816A (ko) 1990-06-02
US5059615A (en) 1991-10-22
CA2003213C (en) 1999-08-03
EP0370300A3 (de) 1991-07-03
CA2003213A1 (en) 1990-05-19
JP2839161B2 (ja) 1998-12-16
ZA898775B (en) 1990-08-29
DE58907399D1 (de) 1994-05-11
KR0128662B1 (ko) 1998-04-04
JPH02243673A (ja) 1990-09-27

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