ES2169068T3 - Anticuerpo monoclonal que reconoce una proteina que se une a fk506, metodo para analizar el nivel de proteina que se une a fk506 y kit para ello. - Google Patents

Anticuerpo monoclonal que reconoce una proteina que se une a fk506, metodo para analizar el nivel de proteina que se une a fk506 y kit para ello.

Info

Publication number
ES2169068T3
ES2169068T3 ES94908103T ES94908103T ES2169068T3 ES 2169068 T3 ES2169068 T3 ES 2169068T3 ES 94908103 T ES94908103 T ES 94908103T ES 94908103 T ES94908103 T ES 94908103T ES 2169068 T3 ES2169068 T3 ES 2169068T3
Authority
ES
Spain
Prior art keywords
fkbp
protein
joins
level
recognizes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908103T
Other languages
English (en)
Inventor
Masakazu Kobayashi
Kazuyuki Ohtsuka
Hirokazu Tanaka
Mineo Niwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2169068T3 publication Critical patent/ES2169068T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN ANTICUERPO MONOCLONAL (ANTICUERPO ANTI-FKBP) QUE RECONOCE UN DETERMINANTE ANTIGENICO PRESENTE EN UNA PROTEINA DE ENLACE FK506 (FKBP) Y NO INHIBE EL ENLACE ENTRE FKBP Y FK506, UN METODO DE ENSAYO DEL NIVEL DE PLASMA FKBP QUE COMPRENDE LA REACCION DE UN ANTICUERPO ANTI-FKBP INMOVILIZADO CON UNA ENZIMA CLASIFICADA FK506 Y FKBP PRESENTE EN UN ESPECIMEN Y DETERMINAR LA EXTENSION DEL DESARROLLO DE COLOR DEL COMPLEJO DE SUBSTRATO DE ENZIMA FORMADO POR EL MISMO, Y UN CONJUNTO PARA ESO. LA INVENCION SIRVE PARA FACILITAR UN ENSAYO MAS EXACTO DE UN NIVEL DE PLASMA FKBP QUE AFECTA A LA ACTIVIDAD INMUNOSUPRESORA DE FK506, POR LO QUE LA DOSIS OPTIMA DE FK506 PUEDE DETERMINARSE EN ESTRECHA COLABORACION CON LA CONDICION DE CADA PACIENTE INDIVIDUAL.
ES94908103T 1992-08-12 1993-08-11 Anticuerpo monoclonal que reconoce una proteina que se une a fk506, metodo para analizar el nivel de proteina que se une a fk506 y kit para ello. Expired - Lifetime ES2169068T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21496792 1992-08-12

Publications (1)

Publication Number Publication Date
ES2169068T3 true ES2169068T3 (es) 2002-07-01

Family

ID=16664530

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94908103T Expired - Lifetime ES2169068T3 (es) 1992-08-12 1993-08-11 Anticuerpo monoclonal que reconoce una proteina que se une a fk506, metodo para analizar el nivel de proteina que se une a fk506 y kit para ello.

Country Status (12)

Country Link
US (1) US5576183A (es)
EP (1) EP0672756B1 (es)
JP (1) JP3185221B2 (es)
KR (1) KR100243536B1 (es)
AT (1) ATE213272T1 (es)
AU (1) AU667743B2 (es)
CA (1) CA2142197C (es)
DE (1) DE69331585T2 (es)
DK (1) DK0672756T3 (es)
ES (1) ES2169068T3 (es)
PT (1) PT672756E (es)
WO (1) WO1994004700A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3993695A (en) * 1994-12-07 1996-06-26 Fujisawa Pharmaceutical Co., Ltd. Method of measuring the concentration of fk506-binding protein
WO1999035160A1 (en) * 1998-01-09 1999-07-15 Human Genome Sciences, Inc. Human fk506 binding proteins
US6492325B1 (en) * 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
US7078495B1 (en) * 1999-08-03 2006-07-18 Dade Behring Inc. Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus
CN1301770A (zh) * 1999-12-29 2001-07-04 复旦大学 一种新的多肽——人fkbp蛋白11和编码这种多肽的多核苷酸
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
WO2006108130A2 (en) * 2005-04-06 2006-10-12 Abbott Laboratories Methods to measure immunosuppressive tacrolimus, sirolimus, and cyclosporin a complexes in a blood sample
KR101158362B1 (ko) 2011-04-20 2012-06-22 한국과학기술원 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1993007269A1 (en) * 1991-10-11 1993-04-15 Vertex Pharmaceuticals Incorporated ISOLATION OF AN Mr 52,000 FK506 BINDING PROTEIN AND MOLECULAR CLONING OF A CORRESPONDING HUMAN cDNA

Also Published As

Publication number Publication date
WO1994004700A1 (en) 1994-03-03
ATE213272T1 (de) 2002-02-15
DK0672756T3 (da) 2002-03-25
AU667743B2 (en) 1996-04-04
DE69331585D1 (de) 2002-03-21
KR950703061A (ko) 1995-08-23
CA2142197C (en) 2004-06-22
AU4761393A (en) 1994-03-15
EP0672756B1 (en) 2002-02-13
PT672756E (pt) 2002-07-31
KR100243536B1 (ko) 2000-02-01
CA2142197A1 (en) 1994-03-03
US5576183A (en) 1996-11-19
DE69331585T2 (de) 2002-08-08
JP3185221B2 (ja) 2001-07-09
EP0672756A4 (en) 1996-10-09
EP0672756A1 (en) 1995-09-20

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