ATE213272T1 - Monoklonaler antikörper spezifisch für das fk-506-bindende protein, methode zur bestimmung des gehaltes an fk-506-bindendem protein in einer probe und reagenzsatz dafür - Google Patents

Monoklonaler antikörper spezifisch für das fk-506-bindende protein, methode zur bestimmung des gehaltes an fk-506-bindendem protein in einer probe und reagenzsatz dafür

Info

Publication number
ATE213272T1
ATE213272T1 AT94908103T AT94908103T ATE213272T1 AT E213272 T1 ATE213272 T1 AT E213272T1 AT 94908103 T AT94908103 T AT 94908103T AT 94908103 T AT94908103 T AT 94908103T AT E213272 T1 ATE213272 T1 AT E213272T1
Authority
AT
Austria
Prior art keywords
fkbp
binding protein
determining
monoclonal antibody
sample
Prior art date
Application number
AT94908103T
Other languages
English (en)
Inventor
Masakazu Kobayashi
Kazuyuki Ohtsuka
Hirokazu Tanaka
Mineo Niwa
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of ATE213272T1 publication Critical patent/ATE213272T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT94908103T 1992-08-12 1993-08-11 Monoklonaler antikörper spezifisch für das fk-506-bindende protein, methode zur bestimmung des gehaltes an fk-506-bindendem protein in einer probe und reagenzsatz dafür ATE213272T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21496792 1992-08-12
PCT/JP1993/001136 WO1994004700A1 (en) 1992-08-12 1993-08-11 Monoclonal antibody recognizing fk506-binding protein, method of assaying fk506-binding protein level, and kit thereof

Publications (1)

Publication Number Publication Date
ATE213272T1 true ATE213272T1 (de) 2002-02-15

Family

ID=16664530

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94908103T ATE213272T1 (de) 1992-08-12 1993-08-11 Monoklonaler antikörper spezifisch für das fk-506-bindende protein, methode zur bestimmung des gehaltes an fk-506-bindendem protein in einer probe und reagenzsatz dafür

Country Status (12)

Country Link
US (1) US5576183A (de)
EP (1) EP0672756B1 (de)
JP (1) JP3185221B2 (de)
KR (1) KR100243536B1 (de)
AT (1) ATE213272T1 (de)
AU (1) AU667743B2 (de)
CA (1) CA2142197C (de)
DE (1) DE69331585T2 (de)
DK (1) DK0672756T3 (de)
ES (1) ES2169068T3 (de)
PT (1) PT672756E (de)
WO (1) WO1994004700A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996018102A1 (fr) * 1994-12-07 1996-06-13 Fujisawa Pharmaceutical Co., Ltd. Methode de mesure de la concentration en proteines de fixation de fk506
JP2002500036A (ja) * 1998-01-09 2002-01-08 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ヒトｆｋ５０６結合タンパク質
US6492325B1 (en) * 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
US7078495B1 (en) * 1999-08-03 2006-07-18 Dade Behring Inc. Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus
CN1301770A (zh) * 1999-12-29 2001-07-04 复旦大学 一种新的多肽——人fkbp蛋白11和编码这种多肽的多核苷酸
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
EP1875250B1 (de) * 2005-04-06 2010-01-27 Abbott Laboratories Verfahren zur messung immunsuppressiver tacrolimus-, sirolimus- und cyclosporin-a-komplexe in einer blutprobe
KR101167649B1 (ko) 2011-04-20 2012-07-20 한국과학기술원 세포 환경 내에서의 단일 분자 수준의 단백질-단백질 상호작용 분석 장치

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
AU2803692A (en) * 1991-10-11 1993-05-03 Vertex Pharmaceuticals Incorporated Isolation of an mr 52,000 fk506 binding protein and molecular cloning of a corresponding human cdna

Also Published As

Publication number Publication date
DK0672756T3 (da) 2002-03-25
DE69331585D1 (de) 2002-03-21
EP0672756A1 (de) 1995-09-20
EP0672756B1 (de) 2002-02-13
WO1994004700A1 (en) 1994-03-03
CA2142197A1 (en) 1994-03-03
ES2169068T3 (es) 2002-07-01
US5576183A (en) 1996-11-19
DE69331585T2 (de) 2002-08-08
JP3185221B2 (ja) 2001-07-09
PT672756E (pt) 2002-07-31
KR100243536B1 (ko) 2000-02-01
CA2142197C (en) 2004-06-22
AU4761393A (en) 1994-03-15
KR950703061A (ko) 1995-08-23
AU667743B2 (en) 1996-04-04
EP0672756A4 (de) 1996-10-09

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee