ES2168297T3 - Fenilalanina-amonio-liasa estabilizada. - Google Patents
Fenilalanina-amonio-liasa estabilizada.Info
- Publication number
 - ES2168297T3 ES2168297T3 ES94919559T ES94919559T ES2168297T3 ES 2168297 T3 ES2168297 T3 ES 2168297T3 ES 94919559 T ES94919559 T ES 94919559T ES 94919559 T ES94919559 T ES 94919559T ES 2168297 T3 ES2168297 T3 ES 2168297T3
 - Authority
 - ES
 - Spain
 - Prior art keywords
 - liasa
 - phenylalanine
 - stabilized
 - ammonia
 - liasen
 - Prior art date
 - Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
 - Expired - Lifetime
 
Links
- 230000015556 catabolic process Effects 0.000 abstract 1
 - 238000007385 chemical modification Methods 0.000 abstract 1
 - 238000006731 degradation reaction Methods 0.000 abstract 1
 - 238000012239 gene modification Methods 0.000 abstract 1
 - 230000005017 genetic modification Effects 0.000 abstract 1
 - 235000013617 genetically modified food Nutrition 0.000 abstract 1
 - 238000000034 method Methods 0.000 abstract 1
 - 239000008194 pharmaceutical composition Substances 0.000 abstract 1
 - COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical compound OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
 - 238000002360 preparation method Methods 0.000 abstract 1
 - 230000002797 proteolythic effect Effects 0.000 abstract 1
 - 230000006641 stabilisation Effects 0.000 abstract 1
 - 238000011105 stabilization Methods 0.000 abstract 1
 
Classifications
- 
        
- C—CHEMISTRY; METALLURGY
 - C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
 - C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
 - C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
 - C12N9/88—Lyases (4.)
 
 - 
        
- A—HUMAN NECESSITIES
 - A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
 - A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
 - A61K38/00—Medicinal preparations containing peptides
 
 
Landscapes
- Health & Medical Sciences (AREA)
 - Life Sciences & Earth Sciences (AREA)
 - Chemical & Material Sciences (AREA)
 - Zoology (AREA)
 - Genetics & Genomics (AREA)
 - Engineering & Computer Science (AREA)
 - Bioinformatics & Cheminformatics (AREA)
 - Organic Chemistry (AREA)
 - Wood Science & Technology (AREA)
 - General Engineering & Computer Science (AREA)
 - Microbiology (AREA)
 - Biotechnology (AREA)
 - Medicinal Chemistry (AREA)
 - Biochemistry (AREA)
 - Molecular Biology (AREA)
 - General Health & Medical Sciences (AREA)
 - Biomedical Technology (AREA)
 - Enzymes And Modification Thereof (AREA)
 - Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
 - Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
 - Detergent Compositions (AREA)
 - Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
 - Lubricants (AREA)
 - Micro-Organisms Or Cultivation Processes Thereof (AREA)
 - Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
 - Medicinal Preparation (AREA)
 - Preparation Of Compounds By Using Micro-Organisms (AREA)
 
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| DK93755A DK75593D0 (h) | 1993-06-25 | 1993-06-25 | 
Publications (1)
| Publication Number | Publication Date | 
|---|---|
| ES2168297T3 true ES2168297T3 (es) | 2002-06-16 | 
Family
ID=8097168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| ES94919559T Expired - Lifetime ES2168297T3 (es) | 1993-06-25 | 1994-06-09 | Fenilalanina-amonio-liasa estabilizada. | 
Country Status (10)
| Country | Link | 
|---|---|
| US (1) | US5753487A (h) | 
| EP (1) | EP0703788B1 (h) | 
| AT (1) | ATE209044T1 (h) | 
| AU (1) | AU7067594A (h) | 
| CA (1) | CA2165281A1 (h) | 
| DE (1) | DE69429167T2 (h) | 
| DK (2) | DK75593D0 (h) | 
| ES (1) | ES2168297T3 (h) | 
| PT (1) | PT703788E (h) | 
| WO (1) | WO1995000171A1 (h) | 
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| US6051020A (en) | 1994-02-09 | 2000-04-18 | Boston Scientific Technology, Inc. | Bifurcated endoluminal prosthesis | 
| ES2227611T3 (es) | 1995-09-29 | 2005-04-01 | Biomarin Pharmaceutical Inc | Uso de heparinas para disminuir repuestas inflamatorias. | 
| US5647368A (en) * | 1996-02-28 | 1997-07-15 | Xillix Technologies Corp. | Imaging system for detecting diseased tissue using native fluorsecence in the gastrointestinal and respiratory tract | 
| US6190883B1 (en) | 1998-09-09 | 2001-02-20 | Novo Nordisk A/S | Method for the production of heterologous polypeptides in transformed yeast cells | 
| US6368837B1 (en) | 1999-08-06 | 2002-04-09 | E. I. Du Pont Nemours And Company | Bioproduction of para-hydroxycinnamic acid | 
| US6521748B2 (en) | 1999-08-06 | 2003-02-18 | E. I. Du Pont De Nemours And Company | Polynucleotide encoding a mutant Rhodotorula glutinis tyrosine ammonia lyase polypeptide | 
| EP1372703A2 (en) * | 2001-02-16 | 2004-01-02 | Ibex Technologies | Matrix stabilized enzyme crystals and methods of use | 
| JP2008513027A (ja) * | 2004-09-17 | 2008-05-01 | バイオマリン ファーマシューティカル インコーポレイテッド | フェニルアラニンアンモニアーリアーゼの改変体および化学的に修飾された改変体 | 
| US20090038023A1 (en) | 2005-03-10 | 2009-02-05 | Verenium Corporation | Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them | 
| US20070122344A1 (en) | 2005-09-02 | 2007-05-31 | University Of Rochester Medical Center Office Of Technology Transfer | Intraoperative determination of nerve location | 
| US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof | 
| US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof | 
| US20080161744A1 (en) | 2006-09-07 | 2008-07-03 | University Of Rochester Medical Center | Pre-And Intra-Operative Localization of Penile Sentinel Nodes | 
| US7537923B2 (en) | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof | 
| US8406860B2 (en) | 2008-01-25 | 2013-03-26 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue | 
| US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery | 
| EP2687235A3 (en) | 2008-05-02 | 2014-11-05 | Novadaq Technologies Inc. | Methods for production and use of substance-loaded erythrocytes (S-LES) for observation and treatment of microvascular hemodynamics | 
| US9376659B2 (en) * | 2008-07-24 | 2016-06-28 | Arch Personal Care Products, L.P. | Personal care composition containing yeast/polyphenol ferment extract | 
| US20110201022A1 (en) * | 2008-07-30 | 2011-08-18 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase | 
| US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest | 
| US20130039898A1 (en) | 2010-02-04 | 2013-02-14 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof | 
| AU2011272825A1 (en) | 2010-06-30 | 2013-01-10 | Codexis, Inc. | Chemically modified carbonic anhydrases useful in carbon capture systems | 
| WO2013190391A2 (en) | 2012-06-21 | 2013-12-27 | Novadaq Technologies Inc. | Quantification and analysis of angiography and perfusion | 
| EA034034B1 (ru) | 2013-04-18 | 2019-12-20 | Кодексис, Инк. | Сконструированные полипептиды фенилаланин-аммиак-лиазы | 
| HK1244873A1 (zh) | 2014-09-29 | 2018-08-17 | Novadaq Technologies Inc. | 在自体荧光存在下生物材料中目标荧光团的成像 | 
| CA2963450A1 (en) | 2014-10-09 | 2016-04-14 | Novadaq Technologies Inc. | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography | 
| EP3580609B1 (en) | 2017-02-10 | 2023-05-24 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods | 
| MX2019009615A (es) | 2017-02-13 | 2019-10-14 | Codexis Inc | Polipeptidos dise?ados de fenilalanina amonio liasa. | 
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| CH538003A (fr) * | 1968-03-29 | 1973-01-31 | Anvar | Procédé pour l'obtention d'articles textiles porteurs d'enzymes | 
| IT1096208B (it) * | 1978-05-12 | 1985-08-26 | Snam Progetti | Composizione adatta alla riduzione del tenore di fenilalanina e metodo impiegante la stessa | 
| FR2523445A1 (fr) * | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues | 
- 
        1993
        
- 1993-06-25 DK DK93755A patent/DK75593D0/da not_active Application Discontinuation
 
 - 
        1994
        
- 1994-06-09 AU AU70675/94A patent/AU7067594A/en not_active Abandoned
 - 1994-06-09 US US08/556,963 patent/US5753487A/en not_active Expired - Lifetime
 - 1994-06-09 EP EP94919559A patent/EP0703788B1/en not_active Expired - Lifetime
 - 1994-06-09 ES ES94919559T patent/ES2168297T3/es not_active Expired - Lifetime
 - 1994-06-09 PT PT94919559T patent/PT703788E/pt unknown
 - 1994-06-09 WO PCT/DK1994/000224 patent/WO1995000171A1/en active IP Right Grant
 - 1994-06-09 AT AT94919559T patent/ATE209044T1/de not_active IP Right Cessation
 - 1994-06-09 DE DE69429167T patent/DE69429167T2/de not_active Expired - Lifetime
 - 1994-06-09 DK DK94919559T patent/DK0703788T3/da active
 - 1994-06-09 CA CA002165281A patent/CA2165281A1/en not_active Abandoned
 
 
Also Published As
| Publication number | Publication date | 
|---|---|
| WO1995000171A1 (en) | 1995-01-05 | 
| AU7067594A (en) | 1995-01-17 | 
| PT703788E (pt) | 2002-05-31 | 
| DE69429167T2 (de) | 2002-07-04 | 
| EP0703788A1 (en) | 1996-04-03 | 
| US5753487A (en) | 1998-05-19 | 
| DK0703788T3 (da) | 2002-05-21 | 
| DK75593D0 (h) | 1993-06-25 | 
| EP0703788B1 (en) | 2001-11-21 | 
| CA2165281A1 (en) | 1995-01-05 | 
| DE69429167D1 (de) | 2002-01-03 | 
| ATE209044T1 (de) | 2001-12-15 | 
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Legal Events
| Date | Code | Title | Description | 
|---|---|---|---|
| FG2A | Definitive protection | 
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