ES2168091T3 - Proteinas de induccion osea y cartilaginosa. - Google Patents

Proteinas de induccion osea y cartilaginosa.

Info

Publication number
ES2168091T3
ES2168091T3 ES91911087T ES91911087T ES2168091T3 ES 2168091 T3 ES2168091 T3 ES 2168091T3 ES 91911087 T ES91911087 T ES 91911087T ES 91911087 T ES91911087 T ES 91911087T ES 2168091 T3 ES2168091 T3 ES 2168091T3
Authority
ES
Spain
Prior art keywords
osea
cartilaginous
proteins
induction
induction proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911087T
Other languages
English (en)
Spanish (es)
Inventor
Rodney M Hewick
Jack H Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of ES2168091T3 publication Critical patent/ES2168091T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES91911087T 1990-05-16 1991-05-15 Proteinas de induccion osea y cartilaginosa. Expired - Lifetime ES2168091T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52535790A 1990-05-16 1990-05-16
US64120491A 1991-01-15 1991-01-15

Publications (1)

Publication Number Publication Date
ES2168091T3 true ES2168091T3 (es) 2002-06-01

Family

ID=27061763

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91911087T Expired - Lifetime ES2168091T3 (es) 1990-05-16 1991-05-15 Proteinas de induccion osea y cartilaginosa.

Country Status (8)

Country Link
EP (1) EP0536186B1 (fr)
JP (2) JPH06500991A (fr)
AT (1) ATE209251T1 (fr)
CA (1) CA2082941A1 (fr)
DE (1) DE69132823T2 (fr)
DK (1) DK0536186T3 (fr)
ES (1) ES2168091T3 (fr)
WO (1) WO1991018098A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
JP3485917B2 (ja) * 1991-06-25 2004-01-13 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｂｍｐ−９蛋白
DE69233022T2 (de) 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
EP0698095B1 (fr) * 1993-05-12 2004-04-28 Genetics Institute, LLC Compositions de bmp-10
ES2213745T3 (es) * 1993-05-12 2004-09-01 Genetics Institute, Llc Composiciones de bmp-11.
ATE319823T1 (de) 1993-12-07 2006-03-15 Inst Genetics Llc Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
US5645084A (en) * 1995-06-07 1997-07-08 Danek Medical, Inc. Method for spinal fusion without decortication
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
PT831884E (pt) 1995-06-05 2003-11-28 New York Society Uso de proteinas morfogeneticas do caso para cicatrizacao e reparacao da ligacao do tecido conjuntivo
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
US6251671B1 (en) * 1996-02-28 2001-06-26 Vanderbilt University Compositions and methods of making embryonic stem cells
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
JP4388602B2 (ja) 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
ATE278414T1 (de) 1997-05-05 2004-10-15 Curis Inc Therapien zur behandlung von akutem nierenversagen
AU742663B2 (en) 1997-05-30 2002-01-10 Stryker Corporation Methods for evaluating tissue morphogenesis and activity
US20020052026A1 (en) 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6027917A (en) * 1997-12-10 2000-02-22 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6849255B2 (en) 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
EP1119611B1 (fr) 1998-10-06 2006-10-18 Rush University Medical Center Composition pour l'utilisation dans la chemonucleolyse
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
JP4703926B2 (ja) 1999-10-15 2011-06-15 ジェネティクス インスティテュート，エルエルシー 骨形成蛋白をデリバリーするためのヒアルロン酸の処方
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2003093314A2 (fr) 2002-05-03 2003-11-13 Millenium Biologix Inc. Peptides stimulant un tissu conjonctif
WO2004014947A1 (fr) 2002-08-06 2004-02-19 Aventis Pharma Deutschland Gmbh Procede d'isolation d'une proteine intestinale se liant au cholesterol
EP1562986A2 (fr) 2002-11-14 2005-08-17 Adherex Technologies, Inc. Composes et procedes de modulation de fonctions de cadherines classiques
SI1675608T1 (sl) 2003-09-12 2007-08-31 Wyeth Corp Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov
US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
ATE515268T1 (de) 2004-05-25 2011-07-15 Stryker Corp Verwendung von op-1 zur behandlung von knorpeldefekten
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
WO2007092622A2 (fr) 2006-02-09 2007-08-16 Biomimetic Therapeutics, Inc. Compositions et méthodes pour le traitement d'os
US9011930B2 (en) 2006-05-01 2015-04-21 Zycal Bioceuticals Healthcare Company, Inc. Nutritional supplement and use thereof
EP2035030A2 (fr) 2006-05-17 2009-03-18 Stryker Corporation Procédé pour traiter des défauts cartilagineux à l'aide d'un complexe de protèine morphogènique soluble
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
JP5484047B2 (ja) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス， エルエルシー 回旋筋腱板傷害を処置するためのｐｄｇｆ−生体マトリックス組成物および方法
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2117578B1 (fr) * 2007-01-22 2015-04-22 OrthoTrophix, Inc. Composition peptidique et procédé permettant de favoriser la formation de cartilage
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
AU2009236459B2 (en) 2008-04-14 2013-07-25 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
MX2011002555A (es) 2008-09-09 2011-08-03 Biomimetic Therapeutics Inc Composiciones de factor de crecimiento derivadas de plaquetas y metodo para el tratamiento de lesiones de tendon y ligamentos.
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
CN102811622A (zh) 2010-02-22 2012-12-05 生物模拟治疗公司 用于治疗腱病的血小板衍生生长因子组合物和方法
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
JP2016204292A (ja) * 2015-04-21 2016-12-08 国立大学法人 熊本大学 Ｂｍｐ７変異体とアルブミンとの融合体、及び該融合体を含む腎疾患治療剤
AU2016311298A1 (en) 2015-08-25 2018-02-08 Histide Ag Compounds for inducing tissue formation and uses thereof
JP6890836B2 (ja) * 2015-09-17 2021-06-18 ヒスタイド アクツィエンゲゼルシャフト 腫瘍細胞を非腫瘍細胞に変換するための医薬的連合体及びその使用
ES2846848T3 (es) 2015-10-26 2021-07-29 Harvard College Polisacáridos reducidos y oxidados y métodos de uso de los mismos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR900700617A (ko) * 1988-04-08 1990-08-16 브루스 엠. 에이센 뼈 및 연골 유도 조성물
DE69031939T2 (de) * 1989-03-28 1998-09-10 Genetics Institute, Inc., Cambridge, Mass. Osteoinduktive zusammensetzungen
AU663689B2 (en) * 1990-10-18 1995-10-19 Stryker Corporation Osteogenic peptides

Also Published As

Publication number Publication date
EP0536186B1 (fr) 2001-11-21
WO1991018098A1 (fr) 1991-11-28
EP0536186A1 (fr) 1993-04-14
CA2082941A1 (fr) 1991-11-17
JP2001245682A (ja) 2001-09-11
JPH06500991A (ja) 1994-01-27
DE69132823D1 (de) 2002-01-03
ATE209251T1 (de) 2001-12-15
DK0536186T3 (da) 2002-05-21
DE69132823T2 (de) 2002-07-18

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