ES2166937T3 - Metodo para preparar n2-arilsulfonil-l-argininamidas. - Google Patents

Metodo para preparar n2-arilsulfonil-l-argininamidas.

Info

Publication number
ES2166937T3
ES2166937T3 ES97113390T ES97113390T ES2166937T3 ES 2166937 T3 ES2166937 T3 ES 2166937T3 ES 97113390 T ES97113390 T ES 97113390T ES 97113390 T ES97113390 T ES 97113390T ES 2166937 T3 ES2166937 T3 ES 2166937T3
Authority
ES
Spain
Prior art keywords
nitro
hydrogen atom
lower alkyl
arginine
quinolinesulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97113390T
Other languages
English (en)
Inventor
Ryoji Kikumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16550431&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2166937(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of ES2166937T3 publication Critical patent/ES2166937T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

METODO DE PREPARACION DE N SUP,2} ROGENO O UN ALQUILO INFERIOR) G} ACION DE N SUP,G} ATOMO DE HIDROGENO O UN ALQUILO INFERIOR) IL. EL METODO CONSIGUE UNA PREPARACION MUY EFICIENTE Y DE ALTO RENDIMIENTO DE N SUP,2} LES COMO PRINCIPIOS ACTIVOS DE MEDICAMENTOS. TAMBIEN SE PROPORCIONA UN NUEVO COMPUESTO N SUP,2} O UN ALQUILO INFERIOR) TRO L PARA LA FABRICACION DE ACIDO (2R, 4R) ,2} L) - L ARGINIL] - 2 - PIPERIDIN - CARBOXILICO.
ES97113390T 1996-08-07 1997-08-04 Metodo para preparar n2-arilsulfonil-l-argininamidas. Expired - Lifetime ES2166937T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20808796 1996-08-07

Publications (1)

Publication Number Publication Date
ES2166937T3 true ES2166937T3 (es) 2002-05-01

Family

ID=16550431

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97113390T Expired - Lifetime ES2166937T3 (es) 1996-08-07 1997-08-04 Metodo para preparar n2-arilsulfonil-l-argininamidas.

Country Status (5)

Country Link
US (1) US5925760A (es)
EP (1) EP0823430B1 (es)
AT (1) ATE207482T1 (es)
DE (1) DE69707603T2 (es)
ES (1) ES2166937T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100465161C (zh) * 2006-11-10 2009-03-04 天津市炜杰科技有限公司 阿加曲班中间体的制备方法
ITPD20080106A1 (it) 2008-04-07 2009-10-08 Lundbeck Pharmaceuticals Italy Spa Metodo di preparazione di argatroban monoidrato
ITMI20110545A1 (it) 2011-04-04 2012-10-05 Lundbeck Pharmaceuticals Italy S P A Metodo per la preparazione di intermedi di processo per la sintesi di argatroban monoidrato
CN104672132B (zh) * 2013-11-28 2017-06-16 四川科瑞德制药股份有限公司 阿加曲班中间体的合成方法
CN109912570A (zh) * 2019-04-04 2019-06-21 天津药物研究院药业有限责任公司 一种阿加曲班中间体酰胺化物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101653A (en) * 1974-11-08 1978-07-18 Mitsubishi Chemical Industries Limited N2 -arylsulfonyl-argininamides and the pharmaceutically acceptable salts thereof
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
JPS60163855A (ja) * 1984-02-06 1985-08-26 Mitsubishi Chem Ind Ltd アルギニン誘導体および薬剤として許容され得るその酸付加塩
GB9505538D0 (en) * 1995-03-18 1995-05-03 Ciba Geigy Ag New compounds

Also Published As

Publication number Publication date
EP0823430A1 (en) 1998-02-11
ATE207482T1 (de) 2001-11-15
DE69707603D1 (de) 2001-11-29
DE69707603T2 (de) 2002-07-11
EP0823430B1 (en) 2001-10-24
US5925760A (en) 1999-07-20

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