ES2164686T3 - Procedimiento de preparacion de amidas de alfa-aminoacidos, utilizables en sintesis peptidica. - Google Patents
Procedimiento de preparacion de amidas de alfa-aminoacidos, utilizables en sintesis peptidica.Info
- Publication number
- ES2164686T3 ES2164686T3 ES94201642T ES94201642T ES2164686T3 ES 2164686 T3 ES2164686 T3 ES 2164686T3 ES 94201642 T ES94201642 T ES 94201642T ES 94201642 T ES94201642 T ES 94201642T ES 2164686 T3 ES2164686 T3 ES 2164686T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- alfa
- procedure
- preparation
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 102000007079 Peptide Fragments Human genes 0.000 abstract 2
- 108010033276 Peptide Fragments Proteins 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE PREPARA UNA AMIDA DE (ALFA) CION DE UN N(ALFA) PUESTO QUE COMPRENDE UN GRUPO AMINO LIBRE. ESTE PROCEDIMIENTO PERMITE PREPARAR FACILMENTE PEPTIDOS MEDIANTE REACCION DIRECTA ENTRE EL GRUPO CARBOXILO DEL DERIVADO N(ALFA) LO DE UN AMINOACIDO Y EL GRUPO AMINO LIBRE DE UN SEGUNDO AMINOACIDO O DE UN FRAGMENTO PEPTIDICO, SIN NECESITAR PROTECCION DE LA FUNCION CARBOXILO DEL SEGUNDO AMINOACIDO O DEL FRAGMENTO PEPTIDICO, NI AGENTE DE ACOPLAMIENTO NI ETAPA DE DESPROTECCION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9300622A BE1007184A3 (fr) | 1993-06-18 | 1993-06-18 | Procede de preparation d'un amide d'alpha-aminoacide, utilisable en synthese peptidique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2164686T3 true ES2164686T3 (es) | 2002-03-01 |
Family
ID=3887113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94201642T Expired - Lifetime ES2164686T3 (es) | 1993-06-18 | 1994-06-09 | Procedimiento de preparacion de amidas de alfa-aminoacidos, utilizables en sintesis peptidica. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5506362A (es) |
| EP (1) | EP0633267B1 (es) |
| JP (1) | JP3466709B2 (es) |
| AT (1) | ATE206134T1 (es) |
| AU (1) | AU684763B2 (es) |
| BE (1) | BE1007184A3 (es) |
| CA (1) | CA2125636C (es) |
| DE (1) | DE69428401T2 (es) |
| ES (1) | ES2164686T3 (es) |
| HU (1) | HU215092B (es) |
| IL (1) | IL109977A (es) |
| SG (1) | SG43028A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6160122A (en) * | 1996-06-28 | 2000-12-12 | Abbott Laboratories | Process for the preparation of a disubstituted thiazole |
| AU4401097A (en) * | 1997-09-18 | 1999-04-05 | Hyundai Pharm. Ind. Co., Ltd. | Amino acid derivatives |
| RS51182B (sr) * | 2004-04-08 | 2010-10-31 | Millennium Pharmaceuticals Inc. | Postupak za dobijanje eptifibatida i odgovarajućih intermedijernih jedinjenja |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3339308A1 (de) * | 1983-10-29 | 1985-07-25 | Heinz Dr. Berndt | Der o-hydroxiphenyloxicarbonyl-rest, eine neue aminoschutzgruppe fuer aminosaeuren, aminosaeure-derivate, peptide sowie peptid-derivate |
| EP0401817B1 (en) * | 1989-06-09 | 1995-09-13 | Research Corporation Technologies, Inc. | Reagents for rapid peptide synthesis |
| DE3936298A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Substituierte aminosaeureamid-derivate deren herstellung und verwendung |
| DE4030062A1 (de) * | 1990-09-22 | 1992-03-26 | Bayer Ag | Substituierte aminosaeureamid-derivate deren herstellung und verwendung |
| BE1005720A3 (fr) * | 1992-03-20 | 1993-12-28 | Solvay | Procede de synthese peptidique et nouveaux intermediaires de synthese. |
-
1993
- 1993-06-18 BE BE9300622A patent/BE1007184A3/fr not_active IP Right Cessation
-
1994
- 1994-06-09 ES ES94201642T patent/ES2164686T3/es not_active Expired - Lifetime
- 1994-06-09 AT AT94201642T patent/ATE206134T1/de active
- 1994-06-09 EP EP94201642A patent/EP0633267B1/fr not_active Expired - Lifetime
- 1994-06-09 US US08/257,293 patent/US5506362A/en not_active Expired - Lifetime
- 1994-06-09 SG SG1996002609A patent/SG43028A1/en unknown
- 1994-06-09 DE DE69428401T patent/DE69428401T2/de not_active Expired - Lifetime
- 1994-06-10 IL IL10997794A patent/IL109977A/xx not_active IP Right Cessation
- 1994-06-10 CA CA002125636A patent/CA2125636C/fr not_active Expired - Lifetime
- 1994-06-17 AU AU64782/94A patent/AU684763B2/en not_active Ceased
- 1994-06-17 HU HU9401818A patent/HU215092B/hu not_active IP Right Cessation
- 1994-06-20 JP JP13711894A patent/JP3466709B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6478294A (en) | 1994-12-22 |
| DE69428401T2 (de) | 2002-06-20 |
| SG43028A1 (en) | 1997-10-17 |
| US5506362A (en) | 1996-04-09 |
| AU684763B2 (en) | 1998-01-08 |
| CA2125636C (fr) | 2008-05-06 |
| ATE206134T1 (de) | 2001-10-15 |
| IL109977A (en) | 1999-10-28 |
| HU215092B (hu) | 1998-09-28 |
| JPH0717998A (ja) | 1995-01-20 |
| EP0633267A1 (fr) | 1995-01-11 |
| CA2125636A1 (fr) | 1994-12-19 |
| BE1007184A3 (fr) | 1995-04-18 |
| JP3466709B2 (ja) | 2003-11-17 |
| IL109977A0 (en) | 1994-10-07 |
| EP0633267B1 (fr) | 2001-09-26 |
| HU9401818D0 (en) | 1994-09-28 |
| HUT71706A (en) | 1996-01-29 |
| DE69428401D1 (de) | 2001-10-31 |
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| ES2164686T3 (es) | Procedimiento de preparacion de amidas de alfa-aminoacidos, utilizables en sintesis peptidica. | |
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| KR790001842B1 (ko) | 신규 폴리펩티드의 제조법 | |
| JPS5834120B2 (ja) | ペプチドの製造方法 | |
| ATE137741T1 (de) | Aminosäurederivate zur peptidsynthese |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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