ES2163964A1 - Peptidos derivados del extremo amino de la vp5 de orbivirus y su empleo en diagnostico y vacunas. - Google Patents

Peptidos derivados del extremo amino de la vp5 de orbivirus y su empleo en diagnostico y vacunas.

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Publication number
ES2163964A1
ES2163964A1 ES009900360A ES9900360A ES2163964A1 ES 2163964 A1 ES2163964 A1 ES 2163964A1 ES 009900360 A ES009900360 A ES 009900360A ES 9900360 A ES9900360 A ES 9900360A ES 2163964 A1 ES2163964 A1 ES 2163964A1
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Spain
Prior art keywords
orbivirus
vaccines
peptides
diagnosis
peptides derived
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ES009900360A
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English (en)
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ES2163964B1 (es
Inventor
Alvarez Jose Ignacio Casal
Torrecuadrada Jorge L Martinez
Moreno Angel Venteo
Fernandez Antonio Sanz
Joannes Pieter Langeveld
Marian Longstaff
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Inmunologia y Genetica Aplicada SA
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Inmunologia y Genetica Aplicada SA
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Priority to ES009900360A priority Critical patent/ES2163964B1/es
Publication of ES2163964A1 publication Critical patent/ES2163964A1/es
Application granted granted Critical
Publication of ES2163964B1 publication Critical patent/ES2163964B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Peptidos derivados del extremo amino de la VP5 de orbivirus y su empleo en diagnóstico y vacunas. Los péptidos contienen secuencias de 6 a 20 aminoácidos contiguos contenidos en la región comprendida entre los restos de los aminoácidos 70 a 95 de la VP5 de un orbivirus, en particular del VPEA-4. Dicha región contiene varios sitios antigénicos y al menos un determinante antigénico reconocido específicamente por un anticuerpo monoclonal frente a dicho determinante antigénico. Dichos péptidos y anticuerpo monoclonal pueden ser utilizados como reactivos de diagnóstico para orbivirus, particularmente mediante un inmunoensayo basado en un ELISA de bloqueo. Estos péptidos también inducen la producción de anticuerpos neutralizantes del virus y pueden utilizarse en la formulación de vacunas.
ES009900360A 1999-02-22 1999-02-22 Peptidos derivados del extremo amino de la vp5 de orbivirus y su empleo en diagnostico y vacunas. Expired - Fee Related ES2163964B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES009900360A ES2163964B1 (es) 1999-02-22 1999-02-22 Peptidos derivados del extremo amino de la vp5 de orbivirus y su empleo en diagnostico y vacunas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009900360A ES2163964B1 (es) 1999-02-22 1999-02-22 Peptidos derivados del extremo amino de la vp5 de orbivirus y su empleo en diagnostico y vacunas.

Publications (2)

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ES2163964A1 true ES2163964A1 (es) 2002-02-01
ES2163964B1 ES2163964B1 (es) 2003-04-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900360A Expired - Fee Related ES2163964B1 (es) 1999-02-22 1999-02-22 Peptidos derivados del extremo amino de la vp5 de orbivirus y su empleo en diagnostico y vacunas.

Country Status (1)

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ES (1) ES2163964B1 (es)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SAKAMOTO et al., "The complete sequences of african horsesickness virus serotype 4 (vaccine strain) RNA segment 2 and 6 which encode outer capsid protein". 1994. J. Vet. Med. Sci. Vol. 56 (2), paginas 321-7. *
WANG et al., "Use of a gene-targeted phage display random epitope library to map an antigenic determinant of the bluetongue virus outer capsid protein UP5". 1995. J. Immunol. Methods. Vol. 178 (1), paginas 1-12. *
YANG et al., "Epitopic mapping of linear and conformation-dependent antigenic determinants on GP5 of five U.S. bluetongue viruses". 1992. Virology. Vol. 188 (2), paginas 530-6. *

Also Published As

Publication number Publication date
ES2163964B1 (es) 2003-04-01

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