ES2161167A1 - Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-flurofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas. - Google Patents

Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-flurofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas.

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Publication number
ES2161167A1
ES2161167A1 ES9902124A ES9902124A ES2161167A1 ES 2161167 A1 ES2161167 A1 ES 2161167A1 ES 9902124 A ES9902124 A ES 9902124A ES 9902124 A ES9902124 A ES 9902124A ES 2161167 A1 ES2161167 A1 ES 2161167A1
Authority
ES
Spain
Prior art keywords
hydrolysis
paroxetine
synthesis intermediates
ester based
based mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9902124A
Other languages
English (en)
Other versions
ES2161167B1 (es
Inventor
Seijas Jose Manuel Guisan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vita Invest SA
Original Assignee
Vita Invest SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest SA filed Critical Vita Invest SA
Priority to ES009902124A priority Critical patent/ES2161167B1/es
Publication of ES2161167A1 publication Critical patent/ES2161167A1/es
Application granted granted Critical
Publication of ES2161167B1 publication Critical patent/ES2161167B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento de hidrólisis enzimática de ésteres del ácido (3SR,4RS)-4-(4-fluorofenil)-6-oxopiperidin-3-carboxílico con biocatalizadores de lipasas o esterasas inmovilizadas. El procedimiento consiste en la hidrólisis enantioselectiva de una mezcla racémica de un éster del ácido(3SR,4RS)-4-(4-fluorofenil)- 6-oxopiperidin-3- carboxílico de fórmula (I), para obtener el ácido de fórmula (IIa) enantioméricamente puro o bien, el éster de fórmula (Ia), sin hidrolizar, enantioméricamente puro. Ambos compuestos de fórmula (IIa) y (Ia) son importantes intermedios en la síntesis de paroxetina. El procedimiento de hidrólisis se caracteriza porque se lleva a cabo en medios acuosos, en condiciones suaves de pH y temperatura, y por utilizar como catalizadores derivados de lipasas o esterasas de diferente origen obtenidos por inmovilización de las enzimas en distintos soportes.
ES009902124A 1999-09-24 1999-09-24 Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-fluorofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas. Expired - Fee Related ES2161167B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES009902124A ES2161167B1 (es) 1999-09-24 1999-09-24 Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-fluorofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902124A ES2161167B1 (es) 1999-09-24 1999-09-24 Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-fluorofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas.

Publications (2)

Publication Number Publication Date
ES2161167A1 true ES2161167A1 (es) 2001-11-16
ES2161167B1 ES2161167B1 (es) 2002-07-01

Family

ID=8310050

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009902124A Expired - Fee Related ES2161167B1 (es) 1999-09-24 1999-09-24 Procedimiento de hidrolisis enzimatica de esteres del acido (3sr,4rs)-4-(4-fluorofenil)-6-oxopiperidin-3-carboxilico con biocatalizadores de lipasas o esterasas inmovilizadas.

Country Status (1)

Country Link
ES (1) ES2161167B1 (es)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022284A1 (en) * 1992-05-06 1993-11-11 Smithkline Beecham Plc Process for stereospecific hydrolysis of piperidinedione derivatives
WO1994003428A1 (en) * 1992-08-06 1994-02-17 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
WO1998002556A2 (en) * 1996-07-15 1998-01-22 Smithkline Beecham Plc Screening for and use of an esterase for a stereospecific resolution
ES2145702A1 (es) * 1998-04-03 2000-07-01 Vita Invest Sa Procedimiento enzimatico de obtencion de (r)-2-hidroxi-4-fenilbutanoato de etilo enantiomericamente puro utilizando biocatalizadores de lipasas inmovilizadas.
ES2147121A1 (es) * 1998-04-03 2000-08-16 Vita Invest Sa Nuevos biocatalizadores de lipasas inmovilizadas.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022284A1 (en) * 1992-05-06 1993-11-11 Smithkline Beecham Plc Process for stereospecific hydrolysis of piperidinedione derivatives
WO1994003428A1 (en) * 1992-08-06 1994-02-17 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
WO1998002556A2 (en) * 1996-07-15 1998-01-22 Smithkline Beecham Plc Screening for and use of an esterase for a stereospecific resolution
ES2145702A1 (es) * 1998-04-03 2000-07-01 Vita Invest Sa Procedimiento enzimatico de obtencion de (r)-2-hidroxi-4-fenilbutanoato de etilo enantiomericamente puro utilizando biocatalizadores de lipasas inmovilizadas.
ES2147121A1 (es) * 1998-04-03 2000-08-16 Vita Invest Sa Nuevos biocatalizadores de lipasas inmovilizadas.

Also Published As

Publication number Publication date
ES2161167B1 (es) 2002-07-01

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