ES2159380T3 - Compuestos de (n-(piridinilmetil)-heterociclo)ilidenamina como agentes que se unen al receptor nicotinico de acetilcolina. - Google Patents

Compuestos de (n-(piridinilmetil)-heterociclo)ilidenamina como agentes que se unen al receptor nicotinico de acetilcolina.

Info

Publication number
ES2159380T3
ES2159380T3 ES97309220T ES97309220T ES2159380T3 ES 2159380 T3 ES2159380 T3 ES 2159380T3 ES 97309220 T ES97309220 T ES 97309220T ES 97309220 T ES97309220 T ES 97309220T ES 2159380 T3 ES2159380 T3 ES 2159380T3
Authority
ES
Spain
Prior art keywords
compounds
piridinilmetil
ilidenamine
acetilcoline
heterociclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97309220T
Other languages
English (en)
Inventor
Peter Hans Dorff
Steven Wayne Goldstein
Stanley Jung
Arthur Adam Nagel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2159380T3 publication Critical patent/ES2159380T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN COMPUESTO (N (PIRIDINILMETIL) HETEROCICLICOS)ILIDENEAMINA DE LA FORMULA DONDE R 3 , A Y B SE DESCRIBEN MAS ADELA NTE, Y SUS SALES Y PROFARMACOS FARMACEUTICAMENTE ACEPTABLES. LOS COMPUESTOS DE LA FORMULA I Y SUS SALES Y PROFARMACOS FARMACEUTICAMENTE ACEPTABLES SON UTILES EN EL TRATAMIENTO DE TRASTORNOS ADICTIVOS, TALES COMO EL USO DEL TABACO Y OTROS PRODUCTOS QUE CONTIENEN NICOTINA, TRASTORNOS NEUROLOGICOS Y MENTALES TALES COMO LA DEMENCIA SENIL DE TIPO ALZHEIMER, ENFERMEDAD DE PARKINSON, TRASTORNO DE ATENCION DE HIPERACTIVIDAD, ANSIEDAD, OBESIDAD, SINDROME DE TOURETTE Y COLITIS ULCEROSA.
ES97309220T 1997-02-06 1997-11-17 Compuestos de (n-(piridinilmetil)-heterociclo)ilidenamina como agentes que se unen al receptor nicotinico de acetilcolina. Expired - Lifetime ES2159380T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3803697P 1997-02-06 1997-02-06

Publications (1)

Publication Number Publication Date
ES2159380T3 true ES2159380T3 (es) 2001-10-01

Family

ID=21897750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97309220T Expired - Lifetime ES2159380T3 (es) 1997-02-06 1997-11-17 Compuestos de (n-(piridinilmetil)-heterociclo)ilidenamina como agentes que se unen al receptor nicotinico de acetilcolina.

Country Status (10)

Country Link
US (1) US6020335A (es)
EP (1) EP0857725B1 (es)
JP (2) JP3542893B2 (es)
AT (1) ATE203535T1 (es)
CA (1) CA2220438C (es)
DE (1) DE69705817T2 (es)
DK (1) DK0857725T3 (es)
ES (1) ES2159380T3 (es)
GR (1) GR3036626T3 (es)
PT (1) PT857725E (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2366260A1 (en) * 1999-03-05 2000-09-14 Masahiro Imoto Heterocyclic compounds having effect of activating .alpha.4.beta.2 nicotinic acetylcholine receptors
JP2001302635A (ja) * 2000-04-21 2001-10-31 Suntory Ltd 新規複素環化合物
DE60208630T2 (de) * 2001-05-11 2006-08-17 Pfizer Products Inc., Groton Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
US20030134844A1 (en) * 2001-10-31 2003-07-17 Pfizer Inc. Nicontinic acetylcholine receptor antagonists in the treatment of restless legs syndrome
PL370549A1 (en) * 2001-10-31 2005-05-30 Pfizer Products Inc. Nicotinic acetylcholine receptor agonists in the treatment of restless legs syndrome
EP1451202B1 (en) 2001-11-30 2008-08-20 Pfizer Products Inc. Aryl fused azapolycyclic compounds
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
BRPI0412712A (pt) 2003-07-21 2006-09-26 Pfizer Prod Inc compostos azapolicìclicos fundidos com heteroarila
WO2006006071A1 (en) * 2004-07-07 2006-01-19 Pfizer Products Inc. Resolution of an aryl-fused azapolycyclic compound
US7780981B2 (en) 2004-09-13 2010-08-24 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
DK1951663T3 (en) * 2005-11-24 2016-10-10 Dompé Farm S P A (r)-arylkylaminoderivater og farmaceutiske sammensætninger indeholdende dem
KR20110075044A (ko) 2007-04-02 2011-07-05 파킨슨즈 인스티튜트 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물
US20100233503A1 (en) * 2009-03-13 2010-09-16 Zachman Joseph M Panel for a storage container
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2974324A1 (en) 2015-01-28 2016-08-04 Zita S. Netzel Drug delivery methods and systems
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6230780A (ja) * 1985-04-17 1987-02-09 Ss Pharmaceut Co Ltd １，７−ナフチリジン誘導体及びこれを含有する薬剤
US5814645A (en) * 1993-03-24 1998-09-29 Bayer Aktiengesellschaft Arylor hetaryl substituted nitrogen heterocycles and their use as pesticides
DE4417742A1 (de) * 1994-05-20 1995-11-23 Bayer Ag Nicht-systemische Bekämpfung von Parasiten

Also Published As

Publication number Publication date
CA2220438C (en) 2005-08-16
JP2004175809A (ja) 2004-06-24
ATE203535T1 (de) 2001-08-15
GR3036626T3 (en) 2001-12-31
JP3542893B2 (ja) 2004-07-14
DE69705817T2 (de) 2001-11-08
EP0857725B1 (en) 2001-07-25
PT857725E (pt) 2001-11-30
US6020335A (en) 2000-02-01
EP0857725A1 (en) 1998-08-12
JPH10226684A (ja) 1998-08-25
DK0857725T3 (da) 2001-09-24
CA2220438A1 (en) 1998-08-06
DE69705817D1 (de) 2001-08-30
MX9709164A (es) 1998-09-30

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