ES2157295T3 - Metodo para diagnosticar trastornos de la coagulacion de la sangre. - Google Patents

Metodo para diagnosticar trastornos de la coagulacion de la sangre.

Info

Publication number
ES2157295T3
ES2157295T3 ES95304016T ES95304016T ES2157295T3 ES 2157295 T3 ES2157295 T3 ES 2157295T3 ES 95304016 T ES95304016 T ES 95304016T ES 95304016 T ES95304016 T ES 95304016T ES 2157295 T3 ES2157295 T3 ES 2157295T3
Authority
ES
Spain
Prior art keywords
sample
ratio
protein
exogenous
rate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95304016T
Other languages
English (en)
Other versions
ES2157295T5 (es
Inventor
Kenneth William Ernest Denson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diagnostic Reagents Ltd
Original Assignee
Diagnostic Reagents Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8217962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157295(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diagnostic Reagents Ltd filed Critical Diagnostic Reagents Ltd
Publication of ES2157295T3 publication Critical patent/ES2157295T3/es
Application granted granted Critical
Publication of ES2157295T5 publication Critical patent/ES2157295T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
    • G01N2333/4613—Snake venom
    • G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)

Abstract

SE PROPORCIONA UN METODO Y UN ACCESORIO PARA CRIBAR UN PLASMA SANGUINEO PARA UN COFACTOR APC. EL METODO COMPRENDE: (I) INCUBAR UNA PRIMERA PORCION DE LA MUESTRA CON (A) UN REACTIVO EXOGENO QUE CONTENGA FOSFOLIPIDO QUE ACTIVE EL MECANISMO DE CONTACTO EN LA COAGULACION INTRINSECA O UN REACTIVO EXOGENO QUE INICIE LA COAGULACION EXTRINSECA; E INCUBACION DE UNA SEGUNDA PORCION DE LA MUESTRA CON (B) EL REACTIVO DEL PASO (I) (A) Y UN ACTIVADOR DE PROTEINA C (PC) EXOGENA QUE PRODUZCA PC ACTIVADO (APC) A PARTIR DE LA PROTEINA C Y LA PROTEINA S ENDOGENO. (II) AÑADIR A CADA UNA DE LAS DOS PORCIONES UN AGENTE DE COAGULACION Y MONITORIZAR LA VELOCIDAD DE CONVERSION DE FIBRINOGENO A FIBRINA INSOLUBLE; Y (III) CALCULAR EL INDICE DE TIEMPO VELOCIDAD DE SEGUNDA PORCION DE LA MUESTRA CON LA VELOCIDAD DE LA PRIMERA PORCION Y COMPARAR ESTE INDICE CON EL INDICE CORRESPONDIENTE DE MUESTRAS DE SUJETOS NORMALES.
ES95304016T 1994-12-23 1995-06-09 Metodo para diagnosticar trastornos de la coagulacion de la sangre. Expired - Lifetime ES2157295T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94309764 1994-12-23
EP94309764 1994-12-23

Publications (2)

Publication Number Publication Date
ES2157295T3 true ES2157295T3 (es) 2001-08-16
ES2157295T5 ES2157295T5 (es) 2005-07-01

Family

ID=8217962

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95304016T Expired - Lifetime ES2157295T5 (es) 1994-12-23 1995-06-09 Metodo para diagnosticar trastornos de la coagulacion de la sangre.

Country Status (4)

Country Link
EP (1) EP0718628B2 (es)
AT (1) ATE200710T1 (es)
DE (1) DE69520725T3 (es)
ES (1) ES2157295T5 (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508873A1 (fr) † 1981-07-06 1983-01-07 Rhone Poulenc Films Procede d'emballage de materiaux sensibles a l'oxygene et/ou a la vapeur d'eau
DE3607559A1 (de) * 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
DE608235T1 (de) † 1991-11-13 1994-12-22 Bjoern Dahlbaeck Vefahren zur diagnose von störungen der blutgerinnung.
NZ261190A (en) * 1993-01-29 1997-12-19 Bjorn Dahlback Assaying for functional activity of a blood coagulation component involved in the protein c anticoagulant system (protein c, activated protein c, protein s or anticoagulant factor v)
DE4427785A1 (de) † 1994-08-08 1996-02-15 Behringwerke Ag Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
ATE198772T1 (de) † 1994-11-10 2001-02-15 Dade Behring Marburg Gmbh Verfahren zum spezifischen nachweis eines aktivierten gerinnungsfaktors v mit einer erhöhten stabilität gegenüber aktiviertem protein c
DE19506236B4 (de) † 1995-02-23 2006-06-29 Afs Federhenn Maschinen Gmbh Verfahren zum Verschweißen von vier Kunststoffprofilen

Also Published As

Publication number Publication date
EP0718628B1 (en) 2001-04-18
EP0718628A1 (en) 1996-06-26
DE69520725T2 (de) 2001-11-15
DE69520725T3 (de) 2005-11-17
DE69520725D1 (de) 2001-05-23
EP0718628B2 (en) 2005-02-23
ES2157295T5 (es) 2005-07-01
ATE200710T1 (de) 2001-05-15

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