ES2155512T3 - Composiciones farmaceuticas de microparticulas de forma micelar. - Google Patents

Composiciones farmaceuticas de microparticulas de forma micelar.

Info

Publication number
ES2155512T3
ES2155512T3 ES95901066T ES95901066T ES2155512T3 ES 2155512 T3 ES2155512 T3 ES 2155512T3 ES 95901066 T ES95901066 T ES 95901066T ES 95901066 T ES95901066 T ES 95901066T ES 2155512 T3 ES2155512 T3 ES 2155512T3
Authority
ES
Spain
Prior art keywords
microparticles
less
fatty acid
chain length
miscible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95901066T
Other languages
English (en)
Inventor
Young W Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isomed Inc
Original Assignee
Isomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isomed Inc filed Critical Isomed Inc
Application granted granted Critical
Publication of ES2155512T3 publication Critical patent/ES2155512T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION FARMACEUTICA COMPRENDE MICROPARTICULAS EN MICELO, LAS MICROPARTICULAS CONTIENEN AL MENOS UN AGENTE FARMACOLOGICAMENTE ACTIVO, AL MENOS UN FOSFOLIPIDO SOLUBLE O MISCIBLE EN AGUA, AL MENOS UN FOSFOLIPIDO SOLUBLE O MISCIBLE EN LIPIDO, AL MENOS UN SURFACTANTE NO IONICO QUE TIENE UN VALOR DE ALREDEDOR DE HLB DE ALREDEDOR DE 15 O MAYOR, AL MENOS UN SURFACTANTE NO IONICO QUE TIENE UN VALOR DE HLB SIMILAR O INFERIOR, Y AL MENOS UN COMPUESTO DE ESTEROL SOLUBLE O MISCIBLE EN AGUA. LAS MICROPARTICULAS ESTAN SUSPENDIDAS EN AL MENOS UN ACIDO GRASO QUE TIENE UNA LONGITUD DE CADENA DE C14 O INFERIOR. LA COMPOSICION PUEDE CONTENER OPCIONALMENTE AL MENOS UN ACIDO GRASO QUE TENGA UNA LONGITUD DE CADENA DE C16 O MAYOR EN UNA CONCENTRACION DE ALREDEDOR DE UN 5% W/V O INFERIOR. LA COMPOSICION SE PREPARA MEZCLANDO EL AGENTE FARMACOLOGICAMENTE ACTIVO, LOS FOSFOLIPIDOS, LOS SURFACTANTES Y EL ESTEROL, MICRONIZANDO LA MEZCLA PARA FORMAR MICROPARTICULAS Y SUSPENDIENDO LAS MICROPARTICULAS EN AL MENOS UN ACIDO GRASO DE UNA LONGITUD DE CADENA DE C14 O INFERIOR PARA FORMAR MICROPARTICULAS EN MICELOS. LA INVENCION PUEDE SER UTIL PARA LA ADMINISTRACION ORAL DE DROGAS Y OTROS AGENTES TERAPEUTICOS, ASI COMO PARA LA ADMINISTRACION TRANS-UMBILICO-DERMICA DE TALES DROGAS Y DE AGENTES TERAPEUTICOS.
ES95901066T 1993-11-03 1994-11-03 Composiciones farmaceuticas de microparticulas de forma micelar. Expired - Lifetime ES2155512T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14674793A 1993-11-03 1993-11-03

Publications (1)

Publication Number Publication Date
ES2155512T3 true ES2155512T3 (es) 2001-05-16

Family

ID=22518831

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95901066T Expired - Lifetime ES2155512T3 (es) 1993-11-03 1994-11-03 Composiciones farmaceuticas de microparticulas de forma micelar.

Country Status (10)

Country Link
EP (1) EP0726761B1 (es)
AT (1) ATE198547T1 (es)
CA (1) CA2175494C (es)
DE (1) DE69426570T2 (es)
DK (1) DK0726761T3 (es)
ES (1) ES2155512T3 (es)
GR (1) GR3035727T3 (es)
HK (1) HK1014150A1 (es)
PT (1) PT726761E (es)
WO (1) WO1995012385A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA9711731B (en) 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
ZA9711733B (en) * 1996-12-31 1998-07-01 Monsanto Co Method for solubilization and naturation of somatotropins
US5910319A (en) 1997-05-29 1999-06-08 Eli Lilly And Company Fluoxetine enteric pellets and methods for their preparation and use
CA2324403C (en) * 1999-01-18 2005-12-13 Lg Chemical Limited Lipophilic microparticles containing a protein drug or antigen and formulation comprising same
US6045826A (en) * 1999-04-02 2000-04-04 National Research Council Of Canada Water-soluble compositions of bioactive lipophilic compounds
US20080070981A1 (en) 2000-02-23 2008-03-20 Henryk Borowy-Borowski Water-soluble compositions of bioactive lipophilic compounds
US6632443B2 (en) 2000-02-23 2003-10-14 National Research Council Of Canada Water-soluble compositions of bioactive lipophilic compounds
AU7984200A (en) * 1999-09-21 2001-04-24 Skyepharma Canada Inc. Surface modified particulate compositions of biologically active substances
US7785625B2 (en) 2000-01-14 2010-08-31 Lg Life Sciences, Limited Lipophilic-coated microparticle containing a protein drug and formulation comprising same
EP1677792B1 (en) * 2003-10-31 2015-11-18 Takeda Pharmaceutical Company Limited Solid preparation comprising pioglitazone, glimepiride and a polyoxyethylene sorbitan fatty acid ester
US7345093B2 (en) 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US7659310B2 (en) 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
EP1747782A1 (en) * 2005-07-19 2007-01-31 Cesare Montecucco Products for topical application comprising lysophospholipids and fatty acids
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US9402812B2 (en) 2009-09-23 2016-08-02 Indu JAVERI Methods for the preparation of liposomes
US11278602B2 (en) 2020-03-25 2022-03-22 Therapeutica Borealis Oy Medicine for Covid-19 and treatment
US11638722B2 (en) 2020-03-25 2023-05-02 Therapeutica Borealis Oy C/O Avance Attorneys Ltd. Medicine for Covid-19 and treatment
WO2021191496A1 (en) * 2020-03-25 2021-09-30 Therapeutica Borealis Oy Medicine for covid-19 and treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4993649A (en) * 1988-04-28 1991-02-19 Koenig Larry E Dual auger shredder
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations

Also Published As

Publication number Publication date
DE69426570T2 (de) 2001-08-23
WO1995012385A1 (en) 1995-05-11
HK1014150A1 (en) 1999-09-24
CA2175494A1 (en) 1995-05-11
ATE198547T1 (de) 2001-01-15
PT726761E (pt) 2001-07-31
CA2175494C (en) 2000-09-19
DK0726761T3 (da) 2001-06-18
EP0726761A1 (en) 1996-08-21
GR3035727T3 (en) 2001-07-31
DE69426570D1 (de) 2001-02-15
EP0726761B1 (en) 2001-01-10

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