ES2155349B1 - PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME. - Google Patents

PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME.

Info

Publication number
ES2155349B1
ES2155349B1 ES009802177A ES9802177A ES2155349B1 ES 2155349 B1 ES2155349 B1 ES 2155349B1 ES 009802177 A ES009802177 A ES 009802177A ES 9802177 A ES9802177 A ES 9802177A ES 2155349 B1 ES2155349 B1 ES 2155349B1
Authority
ES
Spain
Prior art keywords
cefixime
antibiotic
orbally
cefalosporine
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009802177A
Other languages
Spanish (es)
Other versions
ES2155349A1 (en
Inventor
Sharma Anil Kumar
Arun Malhotra
Baldey Raj
Sisodia Anuja Chauhan
Debashis Das
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
J K IND Ltd
Original Assignee
J K IND Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J K IND Ltd filed Critical J K IND Ltd
Publication of ES2155349A1 publication Critical patent/ES2155349A1/en
Application granted granted Critical
Publication of ES2155349B1 publication Critical patent/ES2155349B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Procedimiento de preparación de un antibiótico de cefalosporina oralmente activo, Cefixime. La presente invención se refiere a un procedimiento para la preparación de antibiótico de cefalosporina oralmente activo - Cefixime, de fórmula I en el que, a temperatura ambiente y durante 30 a 90 minutos se hace reaccionar el éster de la fórmula II en disolvente orgánico con solución acuosa de base inorgánica en presencia de un catalizador de transferencia de fase, permitiendo que la mezcla resultante se asiente hasta la separación de las fases acuosa y orgánica, aislando el Cefixime de la pureza requerida, por acidificación y a partir de la fase acuosa.Procedure for preparing an orally active cephalosporin antibiotic, Cefixime. The present invention relates to a process for the preparation of orally active cephalosporin antibiotic - Cefixime, of formula I in which, at room temperature and for 30 to 90 minutes, the ester of formula II is reacted in organic solvent with solution aqueous inorganic base in the presence of a phase transfer catalyst, allowing the resulting mixture to settle until the separation of the aqueous and organic phases, isolating the Cefixime from the required purity, by acidification and from the aqueous phase.

ES009802177A 1997-10-08 1998-10-08 PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME. Expired - Fee Related ES2155349B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT102062A PT102062B (en) 1997-10-08 1997-10-08 PROCESS OF PREPARATION OF AN ANTIBIOTIC CEFALOSPORINA ORAL ACTIVE-CEFIXIME

Publications (2)

Publication Number Publication Date
ES2155349A1 ES2155349A1 (en) 2001-05-01
ES2155349B1 true ES2155349B1 (en) 2001-12-01

Family

ID=20085703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009802177A Expired - Fee Related ES2155349B1 (en) 1997-10-08 1998-10-08 PREPARATION PROCEDURE FOR AN ORBALLY ACTIVE CEFALOSPORINE ANTIBIOTIC, CEFIXIME.

Country Status (4)

Country Link
DE (1) DE19846449A1 (en)
ES (1) ES2155349B1 (en)
GB (1) GB2330141A (en)
PT (1) PT102062B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800755B2 (en) * 2002-10-24 2004-10-05 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of cefixime
US8008478B2 (en) 2004-12-21 2011-08-30 Lupin Limited Process for the preparation of cefixime
WO2006103686A1 (en) 2005-03-29 2006-10-05 Hetero Drugs Limited An improved process for the preparation of cefixime

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9424847D0 (en) * 1994-12-09 1995-02-08 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
DE19846449A1 (en) 1999-04-15
PT102062A (en) 1998-06-30
GB2330141A (en) 1999-04-14
GB9821967D0 (en) 1998-12-02
PT102062B (en) 2000-08-31
ES2155349A1 (en) 2001-05-01

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